LCLT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LCLT1_MOUSE
• UniProt AC: Q3UN02
• Protein Name: Lysocardiolipin acyltransferase 1
• Gene Name: Lclat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 376
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages..
• Protein Sequence: MVSWKGIYFILFLFAGSFFGSIFMLGPILPLMFINLSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMIDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYQGEKNFHFTGQSTVPPCKSELRVLVVKLLSIVYWALFCSAMCLLIYLYSPVRWYFIISIVFFVLQERIFGGLEIIELACYRFLHKHPHLNSKKNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	N-linked_Glycosylation	ILPLMFINLSWYRWI HHHHHHHCHHHHHHH	19.43	-
183	Acetylation	RSNDFAEKNGLQKYE CCCCHHHHHCCCEEE	53.54	-
183	Ubiquitination	RSNDFAEKNGLQKYE CCCCHHHHHCCCEEE	53.54	-
259	Acetylation	ADSLPTSKEDLQLWC CCCCCCCHHHHHHHH	58.69	23806337
259	Malonylation	ADSLPTSKEDLQLWC CCCCCCCHHHHHHHH	58.69	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LCLT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LCLT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LCLT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBX28_MOUSE	Fbxo28	physical	26604221
HDAC2_MOUSE	Hdac2	physical	26604221

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.