IKZF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKZF4_MOUSE
• UniProt AC: Q8C208
• Protein Name: Zinc finger protein Eos
• Gene Name: Ikzf4
• Organism: Mus musculus (Mouse).
• Sequence Length: 586
• Subcellular Localization: Nucleus.
• Protein Description: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1. [PubMed: 19696312]
• Protein Sequence: MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERELSGGCAPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLDKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTDAQALTGQPGDEIRDLEMVPDSMLHPSTERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNASGGYEKDVELVAHHGLEPGFGGSLAFVGTEHLRPLRLPPTNCISELTPVISSVYTQMQPIPSRLELPGSREAGEGPEDLGDGGPLLYRARGSLTDPGASPSNGCQDSTDTESNHEDRIGGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MHTPPALPRR -----CCCCCCCCCC	29.66	27180971
91	Phosphorylation	NSQHSSPSRSLSANS CCCCCCCCCCCCCCC	36.13	25266776
104	Phosphorylation	NSIKVEMYSDEESSR CCEEEEEECHHHHHH	10.24	28833060
105	Phosphorylation	SIKVEMYSDEESSRL CEEEEEECHHHHHHH	36.92	28833060
142	Phosphorylation	PLGYCDGSGPEPHSP CCCCCCCCCCCCCCC	37.61	30482847
210	Phosphorylation	LRHIKLHSGEKPFKC EEEEEECCCCCCCCC	60.11	25266776
236	Phosphorylation	ALTGHLRTHSVSSPT HHHCCCCCCCCCCCC	25.51	26745281
238	Phosphorylation	TGHLRTHSVSSPTVG HCCCCCCCCCCCCCC	24.07	26745281
240	Phosphorylation	HLRTHSVSSPTVGKP CCCCCCCCCCCCCCC	33.35	26745281
241	Phosphorylation	LRTHSVSSPTVGKPY CCCCCCCCCCCCCCE	23.57	26745281
243	Phosphorylation	THSVSSPTVGKPYKC CCCCCCCCCCCCEEC	43.78	26745281
319	Phosphorylation	FIDRLANSLTKRKRS HHHHHHHHHHHCCCC	31.63	29176673
321	Phosphorylation	DRLANSLTKRKRSTP HHHHHHHHHCCCCCC	28.73	29176673
335	Acetylation	PQKFVGEKQMRFSLS CCHHCCCEEEEEEHH	43.39	-
342	Phosphorylation	KQMRFSLSDLPYDVN EEEEEEHHHCCCEEC	35.58	25266776
485	Phosphorylation	PPPQPPPTIVVGRHS CCCCCCCEEEECCCC	31.98	28285833
510	Phosphorylation	QEGLLRGTPGPSKEV CCCCCCCCCCCCHHH	20.73	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKZF4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKZF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKZF4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXP3_MOUSE	Foxp3	physical	22579476

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.