| UniProt ID | CD2AP_MOUSE | |
|---|---|---|
| UniProt AC | Q9JLQ0 | |
| Protein Name | CD2-associated protein | |
| Gene Name | Cd2ap | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 637 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Cell projection, ruffle . Cell junction . Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (By similarity). Located at podocyte slit diaphragm between podocyte foot processes (PubMed:10514378, PubMed:11733379). | |
| Protein Description | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. [PubMed: 9741631 May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus] | |
| Protein Sequence | MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERQGNVASLVQRISTYGLPAGGIQPHPQTKAIKKKTKKRQCKVLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTEDGETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDLSAAEKKAFPLKAEEKDEKSLLEQKPSKPAAPQVPPKKPTAPTKASNLLRSPGAVYPKRPEKPVPPPPPAAKINGEVSIISSKIDTEPVSKPKLDPEQLPVRPKSVDLDAFVARNSKETDDVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLKLPKEDDSGNLKPLEFKKDASYSSKSSLSTPSSASKVNTAAFLTPLELKAKAEADDGKRNSVDELRAQIIELLCIVDALKKDHGKELEKLRKELEEEKAMRSNLEVEIAKLKKAVLLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 71 | Ubiquitination | KDDNLPIKRERQGNV CCCCCCCCHHHCCCH | 46.39 | 22790023 | |
| 80 | Phosphorylation | ERQGNVASLVQRIST HHCCCHHHHHHHHHH | 25.45 | 29176673 | |
| 86 | Phosphorylation | ASLVQRISTYGLPAG HHHHHHHHHHCCCCC | 20.12 | 27087446 | |
| 87 | Phosphorylation | SLVQRISTYGLPAGG HHHHHHHHHCCCCCC | 21.16 | 27600695 | |
| 88 | Phosphorylation | LVQRISTYGLPAGGI HHHHHHHHCCCCCCC | 15.18 | 21183079 | |
| 102 | Ubiquitination | IQPHPQTKAIKKKTK CCCCHHCHHHHHHCC | 42.75 | 22790023 | |
| 167 | Phosphorylation | NFVKELESTEDGETH HHHHHHHCCCCCCCC | 50.12 | 23649490 | |
| 168 | Phosphorylation | FVKELESTEDGETHN HHHHHHCCCCCCCCC | 28.81 | 25777480 | |
| 173 | Phosphorylation | ESTEDGETHNAQEES HCCCCCCCCCCCCCC | 26.42 | 25777480 | |
| 180 | Phosphorylation | THNAQEESEVPLTGP CCCCCCCCCCCCCCC | 43.04 | 26239621 | |
| 185 | Phosphorylation | EESEVPLTGPTSPLP CCCCCCCCCCCCCCC | 34.74 | 25777480 | |
| 188 | Phosphorylation | EVPLTGPTSPLPSPG CCCCCCCCCCCCCCC | 44.30 | 25777480 | |
| 189 | Phosphorylation | VPLTGPTSPLPSPGN CCCCCCCCCCCCCCC | 27.80 | 21659605 | |
| 193 | Phosphorylation | GPTSPLPSPGNGSEP CCCCCCCCCCCCCCC | 53.79 | 21659605 | |
| 198 | Phosphorylation | LPSPGNGSEPAPGSV CCCCCCCCCCCCCCC | 44.39 | 25777480 | |
| 204 | Phosphorylation | GSEPAPGSVAQPKKI CCCCCCCCCCCCCEE | 17.14 | 25777480 | |
| 214 | Ubiquitination | QPKKIRGIGFGDIFK CCCEECCCCCCHHHC | 2.72 | 27667366 | |
| 221 | Ubiquitination | IGFGDIFKEGSVKLR CCCCHHHCCCEEEEE | 62.59 | 22790023 | |
| 224 | Phosphorylation | GDIFKEGSVKLRTRT CHHHCCCEEEEEECC | 19.71 | 26824392 | |
| 229 | Phosphorylation | EGSVKLRTRTSSSET CCEEEEEECCCCCCC | 49.05 | 27087446 | |
| 231 | Phosphorylation | SVKLRTRTSSSETEE EEEEEECCCCCCCCC | 32.14 | 20139300 | |
| 232 | Phosphorylation | VKLRTRTSSSETEEK EEEEECCCCCCCCCH | 28.69 | 27087446 | |
| 233 | Phosphorylation | KLRTRTSSSETEEKK EEEECCCCCCCCCHH | 31.42 | 20139300 | |
| 234 | Phosphorylation | LRTRTSSSETEEKKT EEECCCCCCCCCHHC | 48.59 | 27087446 | |
| 236 | Phosphorylation | TRTSSSETEEKKTEK ECCCCCCCCCHHCCC | 51.93 | 29514104 | |
| 252 | Phosphorylation | LILQPLGSRTQNVEV EEEEECCCCCCCEEE | 39.58 | 25338131 | |
| 254 | Phosphorylation | LQPLGSRTQNVEVTK EEECCCCCCCEEECC | 26.62 | 21454597 | |
| 355 | Phosphorylation | PAPKPDLSAAEKKAF CCCCCCCCHHHHHHC | 32.58 | 27149854 | |
| 380 | Phosphorylation | SLLEQKPSKPAAPQV HHHHCCCCCCCCCCC | 59.30 | 22067460 | |
| 399 | Phosphorylation | PTAPTKASNLLRSPG CCCCCCHHHHCCCCC | 29.57 | 26239621 | |
| 404 | Phosphorylation | KASNLLRSPGAVYPK CHHHHCCCCCCCCCC | 27.88 | 27087446 | |
| 431 | Phosphorylation | AKINGEVSIISSKID CEECCEEEEEEEECC | 15.20 | 27841257 | |
| 432 | Ubiquitination | KINGEVSIISSKIDT EECCEEEEEEEECCC | 4.23 | 27667366 | |
| 439 | Phosphorylation | IISSKIDTEPVSKPK EEEEECCCCCCCCCC | 45.74 | 19854140 | |
| 444 | Ubiquitination | IDTEPVSKPKLDPEQ CCCCCCCCCCCCHHH | 46.54 | 27667366 | |
| 457 | Ubiquitination | EQLPVRPKSVDLDAF HHCCCCCCEECHHHH | 53.17 | 22790023 | |
| 458 | Phosphorylation | QLPVRPKSVDLDAFV HCCCCCCEECHHHHH | 24.44 | 27087446 | |
| 469 | Phosphorylation | DAFVARNSKETDDVN HHHHHCCCCCCCCCC | 26.73 | 30352176 | |
| 482 | Phosphorylation | VNFDDIASSENLLHL CCHHHHHCCCCCHHH | 38.22 | 19367708 | |
| 510 | Phosphorylation | GRFNGGHSPTQSPEK CCCCCCCCCCCCHHH | 32.68 | 25521595 | |
| 512 | Phosphorylation | FNGGHSPTQSPEKTL CCCCCCCCCCHHHCC | 44.70 | 27087446 | |
| 514 | Phosphorylation | GGHSPTQSPEKTLKL CCCCCCCCHHHCCCC | 37.19 | 25521595 | |
| 527 | Phosphorylation | KLPKEDDSGNLKPLE CCCCCCCCCCCCCCE | 41.73 | 22067460 | |
| 541 | Phosphorylation | EFKKDASYSSKSSLS EEECCCCCCCCCCCC | 20.77 | - | |
| 545 | Phosphorylation | DASYSSKSSLSTPSS CCCCCCCCCCCCCCC | 38.16 | 30635358 | |
| 546 | Phosphorylation | ASYSSKSSLSTPSSA CCCCCCCCCCCCCCC | 30.03 | 30635358 | |
| 548 | Phosphorylation | YSSKSSLSTPSSASK CCCCCCCCCCCCCCC | 39.97 | 22942356 | |
| 549 | Phosphorylation | SSKSSLSTPSSASKV CCCCCCCCCCCCCCC | 32.27 | 22942356 | |
| 551 | Phosphorylation | KSSLSTPSSASKVNT CCCCCCCCCCCCCCH | 38.33 | 22942356 | |
| 552 | Phosphorylation | SSLSTPSSASKVNTA CCCCCCCCCCCCCHH | 37.45 | 22942356 | |
| 554 | Phosphorylation | LSTPSSASKVNTAAF CCCCCCCCCCCHHHC | 38.80 | 30635358 | |
| 558 | Phosphorylation | SSASKVNTAAFLTPL CCCCCCCHHHCCCHH | 23.50 | 23984901 | |
| 563 | Phosphorylation | VNTAAFLTPLELKAK CCHHHCCCHHHHHHH | 21.26 | 26643407 | |
| 568 | Ubiquitination | FLTPLELKAKAEADD CCCHHHHHHHHHCCC | 38.17 | 22790023 | |
| 580 | Phosphorylation | ADDGKRNSVDELRAQ CCCCCCCCHHHHHHH | 34.67 | 26824392 | |
| 629 | Ubiquitination | NLEVEIAKLKKAVLL CHHHHHHHHHHHHHC | 67.51 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CD2AP_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CD2AP_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CD2AP_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458, AND MASSSPECTROMETRY. | |
