UniProt ID | CSKP_RAT | |
---|---|---|
UniProt AC | Q62915 | |
Protein Name | Peripheral plasma membrane protein CASK | |
Gene Name | Cask | |
Organism | Rattus norvegicus (Rat). | |
Sequence Length | 909 | |
Subcellular Localization |
Nucleus. Cytoplasm. Cell membrane Peripheral membrane protein. |
|
Protein Description | Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.. | |
Protein Sequence | MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHHVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFPPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
41 | Acetylation | TGQQFAVKIVDVAKF CCCEEEEEEEEHHHH | 33.32 | 22902405 | |
41 | Ubiquitination | TGQQFAVKIVDVAKF CCCEEEEEEEEHHHH | 33.32 | - | |
49 | Phosphorylation | IVDVAKFTSSPGLST EEEHHHHCCCCCCCH | 27.82 | 25403869 | |
50 | Phosphorylation | VDVAKFTSSPGLSTE EEHHHHCCCCCCCHH | 37.35 | 25575281 | |
51 | Phosphorylation | DVAKFTSSPGLSTED EHHHHCCCCCCCHHH | 21.67 | 30240740 | |
55 | Phosphorylation | FTSSPGLSTEDLKRE HCCCCCCCHHHHHHH | 35.35 | 22673903 | |
56 | Phosphorylation | TSSPGLSTEDLKREA CCCCCCCHHHHHHHH | 38.26 | 22673903 | |
64 | Phosphorylation | EDLKREASICHMLKH HHHHHHHHHHHHHCC | 22.46 | 28432305 | |
151 | Phosphorylation | PHCVLLASKENSAPV CCEEEEEECCCCCCE | 40.24 | - | |
155 | Phosphorylation | LLASKENSAPVKLGG EEEECCCCCCEEECC | 34.73 | - | |
182 | Phosphorylation | VAGGRVGTPHFMAPE CCCCCCCCCCCCCCH | 15.67 | 30240740 | |
277 | Acetylation | ALNHPWLKERDRYAY HHCCHHHHHCCCEEE | 47.00 | 22902405 | |
313 | Phosphorylation | GAVLAAVSSHKFNSF HHHHHHHHHCCHHHC | 23.23 | 23984901 | |
314 | Phosphorylation | AVLAAVSSHKFNSFY HHHHHHHHCCHHHCC | 24.89 | 23984901 | |
348 | Phosphorylation | LAAERAVSQVLDSLE HHHHHHHHHHHHCHH | 17.37 | 27097102 | |
353 | Phosphorylation | AVSQVLDSLEEIHAL HHHHHHHCHHHHHHH | 33.25 | 27097102 | |
361 | Phosphorylation | LEEIHALTDCSEKDL HHHHHHHHCCCHHHH | 35.42 | 27097102 | |
364 | Phosphorylation | IHALTDCSEKDLDFL HHHHHCCCHHHHHHH | 50.95 | 27097102 | |
460 | Phosphorylation | SDEALRVTPPPTSPY CCCCCCCCCCCCCCC | 24.52 | 27097102 | |
464 | Phosphorylation | LRVTPPPTSPYLNGD CCCCCCCCCCCCCCC | 48.37 | 27097102 | |
465 | Phosphorylation | RVTPPPTSPYLNGDS CCCCCCCCCCCCCCC | 19.81 | 27097102 | |
467 | Phosphorylation | TPPPTSPYLNGDSPE CCCCCCCCCCCCCCC | 16.74 | 27097102 | |
472 | Phosphorylation | SPYLNGDSPESANGD CCCCCCCCCCCCCCC | 31.78 | 27097102 | |
475 | Phosphorylation | LNGDSPESANGDMDM CCCCCCCCCCCCCCH | 30.34 | 27097102 | |
562 | Phosphorylation | MLREMRGSITFKIVP HHHHHCCCCEEEECC | 14.21 | 20067577 | |
575 | Phosphorylation | VPSYRTQSSSCERDS CCCCCCCCCCCCCCC | 24.49 | 28432305 | |
576 | Phosphorylation | PSYRTQSSSCERDSP CCCCCCCCCCCCCCC | 29.23 | 28432305 | |
577 | Phosphorylation | SYRTQSSSCERDSPS CCCCCCCCCCCCCCC | 25.83 | 28432305 | |
582 | Phosphorylation | SSSCERDSPSTSRQS CCCCCCCCCCCCCCC | 27.29 | 30240740 | |
584 | Phosphorylation | SCERDSPSTSRQSPA CCCCCCCCCCCCCCC | 42.86 | 28432305 | |
585 | Phosphorylation | CERDSPSTSRQSPAN CCCCCCCCCCCCCCC | 31.17 | 28432305 | |
586 | Phosphorylation | ERDSPSTSRQSPANG CCCCCCCCCCCCCCC | 32.43 | 28432305 | |
653 | Ubiquitination | QGKLENSKNGTAGLI HHHEECCCCCCCCCC | 71.61 | - | |
679 | Sumoylation | CIAMEKTKQEQQASC HEECCCCHHHHHHCC | 64.01 | - | |
679 | Sumoylation | CIAMEKTKQEQQASC HEECCCCHHHHHHCC | 64.01 | - | |
685 | Phosphorylation | TKQEQQASCTWFGKK CHHHHHHCCCCCCCC | 14.03 | 27097102 | |
687 | Phosphorylation | QEQQASCTWFGKKKK HHHHHCCCCCCCCCH | 22.72 | 27097102 | |
721 | Acetylation | VVKLPAFKRKTLVLL HCCCCCCCCCEEEEE | 55.90 | 22902405 | |
724 | Phosphorylation | LPAFKRKTLVLLGAH CCCCCCCEEEEECCC | 26.57 | 20067577 | |
846 | Phosphorylation | FIAAPTITPGLNEDE EEECCCCCCCCCCHH | 17.49 | 30240740 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
562 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
562 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
724 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
724 | T | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CSKP_RAT !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CSKP_RAT !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...