CSKP_RAT - dbPTM
CSKP_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSKP_RAT
UniProt AC Q62915
Protein Name Peripheral plasma membrane protein CASK
Gene Name Cask
Organism Rattus norvegicus (Rat).
Sequence Length 909
Subcellular Localization Nucleus. Cytoplasm. Cell membrane
Peripheral membrane protein.
Protein Description Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1..
Protein Sequence MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHHVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFPPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
41AcetylationTGQQFAVKIVDVAKF
CCCEEEEEEEEHHHH
33.3222902405
41UbiquitinationTGQQFAVKIVDVAKF
CCCEEEEEEEEHHHH
33.32-
49PhosphorylationIVDVAKFTSSPGLST
EEEHHHHCCCCCCCH
27.8225403869
50PhosphorylationVDVAKFTSSPGLSTE
EEHHHHCCCCCCCHH
37.3525575281
51PhosphorylationDVAKFTSSPGLSTED
EHHHHCCCCCCCHHH
21.6730240740
55PhosphorylationFTSSPGLSTEDLKRE
HCCCCCCCHHHHHHH
35.3522673903
56PhosphorylationTSSPGLSTEDLKREA
CCCCCCCHHHHHHHH
38.2622673903
64PhosphorylationEDLKREASICHMLKH
HHHHHHHHHHHHHCC
22.4628432305
151PhosphorylationPHCVLLASKENSAPV
CCEEEEEECCCCCCE
40.24-
155PhosphorylationLLASKENSAPVKLGG
EEEECCCCCCEEECC
34.73-
182PhosphorylationVAGGRVGTPHFMAPE
CCCCCCCCCCCCCCH
15.6730240740
277AcetylationALNHPWLKERDRYAY
HHCCHHHHHCCCEEE
47.0022902405
313PhosphorylationGAVLAAVSSHKFNSF
HHHHHHHHHCCHHHC
23.2323984901
314PhosphorylationAVLAAVSSHKFNSFY
HHHHHHHHCCHHHCC
24.8923984901
348PhosphorylationLAAERAVSQVLDSLE
HHHHHHHHHHHHCHH
17.3727097102
353PhosphorylationAVSQVLDSLEEIHAL
HHHHHHHCHHHHHHH
33.2527097102
361PhosphorylationLEEIHALTDCSEKDL
HHHHHHHHCCCHHHH
35.4227097102
364PhosphorylationIHALTDCSEKDLDFL
HHHHHCCCHHHHHHH
50.9527097102
460PhosphorylationSDEALRVTPPPTSPY
CCCCCCCCCCCCCCC
24.5227097102
464PhosphorylationLRVTPPPTSPYLNGD
CCCCCCCCCCCCCCC
48.3727097102
465PhosphorylationRVTPPPTSPYLNGDS
CCCCCCCCCCCCCCC
19.8127097102
467PhosphorylationTPPPTSPYLNGDSPE
CCCCCCCCCCCCCCC
16.7427097102
472PhosphorylationSPYLNGDSPESANGD
CCCCCCCCCCCCCCC
31.7827097102
475PhosphorylationLNGDSPESANGDMDM
CCCCCCCCCCCCCCH
30.3427097102
562PhosphorylationMLREMRGSITFKIVP
HHHHHCCCCEEEECC
14.2120067577
575PhosphorylationVPSYRTQSSSCERDS
CCCCCCCCCCCCCCC
24.4928432305
576PhosphorylationPSYRTQSSSCERDSP
CCCCCCCCCCCCCCC
29.2328432305
577PhosphorylationSYRTQSSSCERDSPS
CCCCCCCCCCCCCCC
25.8328432305
582PhosphorylationSSSCERDSPSTSRQS
CCCCCCCCCCCCCCC
27.2930240740
584PhosphorylationSCERDSPSTSRQSPA
CCCCCCCCCCCCCCC
42.8628432305
585PhosphorylationCERDSPSTSRQSPAN
CCCCCCCCCCCCCCC
31.1728432305
586PhosphorylationERDSPSTSRQSPANG
CCCCCCCCCCCCCCC
32.4328432305
653UbiquitinationQGKLENSKNGTAGLI
HHHEECCCCCCCCCC
71.61-
679SumoylationCIAMEKTKQEQQASC
HEECCCCHHHHHHCC
64.01-
679SumoylationCIAMEKTKQEQQASC
HEECCCCHHHHHHCC
64.01-
685PhosphorylationTKQEQQASCTWFGKK
CHHHHHHCCCCCCCC
14.0327097102
687PhosphorylationQEQQASCTWFGKKKK
HHHHHCCCCCCCCCH
22.7227097102
721AcetylationVVKLPAFKRKTLVLL
HCCCCCCCCCEEEEE
55.9022902405
724PhosphorylationLPAFKRKTLVLLGAH
CCCCCCCEEEEECCC
26.5720067577
846PhosphorylationFIAAPTITPGLNEDE
EEECCCCCCCCCCHH
17.4930240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
562SPhosphorylationKinasePRKACAP17612
GPS
562SPhosphorylationKinasePKA-FAMILY-GPS
724TPhosphorylationKinasePRKACAP17612
GPS
724TPhosphorylationKinasePKA-FAMILY-GPS

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSKP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSKP_RAT !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
APBA1_RATApba1physical
9753324

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSKP_RAT

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Related Literatures of Post-Translational Modification

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