CSKP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSKP_RAT
• UniProt AC: Q62915
• Protein Name: Peripheral plasma membrane protein CASK
• Gene Name: Cask
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 909
• Subcellular Localization: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
• Protein Description: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1..
• Protein Sequence: MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHHVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFPPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Acetylation	TGQQFAVKIVDVAKF CCCEEEEEEEEHHHH	33.32	22902405
41	Ubiquitination	TGQQFAVKIVDVAKF CCCEEEEEEEEHHHH	33.32	-
49	Phosphorylation	IVDVAKFTSSPGLST EEEHHHHCCCCCCCH	27.82	25403869
50	Phosphorylation	VDVAKFTSSPGLSTE EEHHHHCCCCCCCHH	37.35	25575281
51	Phosphorylation	DVAKFTSSPGLSTED EHHHHCCCCCCCHHH	21.67	30240740
55	Phosphorylation	FTSSPGLSTEDLKRE HCCCCCCCHHHHHHH	35.35	22673903
56	Phosphorylation	TSSPGLSTEDLKREA CCCCCCCHHHHHHHH	38.26	22673903
64	Phosphorylation	EDLKREASICHMLKH HHHHHHHHHHHHHCC	22.46	28432305
151	Phosphorylation	PHCVLLASKENSAPV CCEEEEEECCCCCCE	40.24	-
155	Phosphorylation	LLASKENSAPVKLGG EEEECCCCCCEEECC	34.73	-
182	Phosphorylation	VAGGRVGTPHFMAPE CCCCCCCCCCCCCCH	15.67	30240740
277	Acetylation	ALNHPWLKERDRYAY HHCCHHHHHCCCEEE	47.00	22902405
313	Phosphorylation	GAVLAAVSSHKFNSF HHHHHHHHHCCHHHC	23.23	23984901
314	Phosphorylation	AVLAAVSSHKFNSFY HHHHHHHHCCHHHCC	24.89	23984901
348	Phosphorylation	LAAERAVSQVLDSLE HHHHHHHHHHHHCHH	17.37	27097102
353	Phosphorylation	AVSQVLDSLEEIHAL HHHHHHHCHHHHHHH	33.25	27097102
361	Phosphorylation	LEEIHALTDCSEKDL HHHHHHHHCCCHHHH	35.42	27097102
364	Phosphorylation	IHALTDCSEKDLDFL HHHHHCCCHHHHHHH	50.95	27097102
460	Phosphorylation	SDEALRVTPPPTSPY CCCCCCCCCCCCCCC	24.52	27097102
464	Phosphorylation	LRVTPPPTSPYLNGD CCCCCCCCCCCCCCC	48.37	27097102
465	Phosphorylation	RVTPPPTSPYLNGDS CCCCCCCCCCCCCCC	19.81	27097102
467	Phosphorylation	TPPPTSPYLNGDSPE CCCCCCCCCCCCCCC	16.74	27097102
472	Phosphorylation	SPYLNGDSPESANGD CCCCCCCCCCCCCCC	31.78	27097102
475	Phosphorylation	LNGDSPESANGDMDM CCCCCCCCCCCCCCH	30.34	27097102
562	Phosphorylation	MLREMRGSITFKIVP HHHHHCCCCEEEECC	14.21	20067577
575	Phosphorylation	VPSYRTQSSSCERDS CCCCCCCCCCCCCCC	24.49	28432305
576	Phosphorylation	PSYRTQSSSCERDSP CCCCCCCCCCCCCCC	29.23	28432305
577	Phosphorylation	SYRTQSSSCERDSPS CCCCCCCCCCCCCCC	25.83	28432305
582	Phosphorylation	SSSCERDSPSTSRQS CCCCCCCCCCCCCCC	27.29	30240740
584	Phosphorylation	SCERDSPSTSRQSPA CCCCCCCCCCCCCCC	42.86	28432305
585	Phosphorylation	CERDSPSTSRQSPAN CCCCCCCCCCCCCCC	31.17	28432305
586	Phosphorylation	ERDSPSTSRQSPANG CCCCCCCCCCCCCCC	32.43	28432305
653	Ubiquitination	QGKLENSKNGTAGLI HHHEECCCCCCCCCC	71.61	-
679	Sumoylation	CIAMEKTKQEQQASC HEECCCCHHHHHHCC	64.01	-
679	Sumoylation	CIAMEKTKQEQQASC HEECCCCHHHHHHCC	64.01	-
685	Phosphorylation	TKQEQQASCTWFGKK CHHHHHHCCCCCCCC	14.03	27097102
687	Phosphorylation	QEQQASCTWFGKKKK HHHHHCCCCCCCCCH	22.72	27097102
721	Acetylation	VVKLPAFKRKTLVLL HCCCCCCCCCEEEEE	55.90	22902405
724	Phosphorylation	LPAFKRKTLVLLGAH CCCCCCCEEEEECCC	26.57	20067577
846	Phosphorylation	FIAAPTITPGLNEDE EEECCCCCCCCCCHH	17.49	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
562	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
562	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
724	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
724	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSKP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSKP_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBA1_RAT	Apba1	physical	9753324

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.