APBA1_RAT - dbPTM
APBA1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APBA1_RAT
UniProt AC O35430
Protein Name Amyloid-beta A4 precursor protein-binding family A member 1
Gene Name Apba1
Organism Rattus norvegicus (Rat).
Sequence Length 839
Subcellular Localization Cytoplasm. Cytoplasm, perinuclear region. Nucleus . Only a small proportion of the protein is nuclear.
Isoform 2: Golgi apparatus.
Protein Description Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta..
Protein Sequence MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationRGECLARSASTESGF
HCCCCHHHCCCCCCC		22.4427097102
81PhosphorylationECLARSASTESGFHN
CCCHHHCCCCCCCCC		33.6727097102
82PhosphorylationCLARSASTESGFHNH
CCHHHCCCCCCCCCC		33.6130411139
84PhosphorylationARSASTESGFHNHTD
HHHCCCCCCCCCCCC		47.0130411139
90PhosphorylationESGFHNHTDTAEGDV
CCCCCCCCCCCCCCH		40.1227097102
92PhosphorylationGFHNHTDTAEGDVLA
CCCCCCCCCCCCHHH		27.9727097102
239PhosphorylationLGARLHHYDERSDGE
HHHHHCCCCCCCCCC		14.5725575281
243PhosphorylationLHHYDERSDGESDSP
HCCCCCCCCCCCCCH		48.1730240740
247PhosphorylationDERSDGESDSPEKEA
CCCCCCCCCCHHHHH		49.2530240740
249PhosphorylationRSDGESDSPEKEAEF
CCCCCCCCHHHHHHC		44.2130240740
264PhosphorylationAPYPRMDSYEQEEDI
CCCCCCCCCCCCCCH		22.6430240740
265PhosphorylationPYPRMDSYEQEEDID
CCCCCCCCCCCCCHH		19.8428551015
281PhosphorylationIVAEVKQSMSSQSLD
HHHHHHHHHCHHHHH		18.2128551015
283PhosphorylationAEVKQSMSSQSLDKA
HHHHHHHCHHHHHHH		30.3928432305
284PhosphorylationEVKQSMSSQSLDKAA
HHHHHHCHHHHHHHH		18.3628432305
286PhosphorylationKQSMSSQSLDKAAED
HHHHCHHHHHHHHHH		40.2525403869
306PhosphorylationQDLERAPTPGGGHPD
HHHHHCCCCCCCCCC		33.3127097102
314PhosphorylationPGGGHPDSPGLPAPA
CCCCCCCCCCCCCCC		25.8927097102
330PhosphorylationQQQRVVGTPGGSEVG
CCCCEEECCCCCHHH		13.7230240740
334PhosphorylationVVGTPGGSEVGQRYS
EEECCCCCHHHHHHC		34.7230240740
369PhosphorylationVKTRTIRSPYTPDEP
HHHCCCCCCCCCCCC		20.5730240740
372PhosphorylationRTIRSPYTPDEPKEP
CCCCCCCCCCCCCCC		27.8730240740
388PhosphorylationWVMRQDISPTRDCDD
EEEECCCCCCCCCCC		28.6325403869
390PhosphorylationMRQDISPTRDCDDQR
EECCCCCCCCCCCCC		32.1428551015
403PhosphorylationQRPVDGDSPSPGSSS
CCCCCCCCCCCCCCC		32.57-
405PhosphorylationPVDGDSPSPGSSSPL
CCCCCCCCCCCCCCC		45.93-
408PhosphorylationGDSPSPGSSSPLGAE
CCCCCCCCCCCCCCC		30.9030240740
410PhosphorylationSPSPGSSSPLGAESS
CCCCCCCCCCCCCCC		26.3330240740
500AcetylationSRIKTAQKLAKSRKK
HHHHHHHHHHHHHCC		48.2025786129
503AcetylationKTAQKLAKSRKKAPE
HHHHHHHHHHCCCCC		62.3225786129
507AcetylationKLAKSRKKAPEGESQ
HHHHHHCCCCCCCCC		68.9825786129
568PhosphorylationARRRMPRSNSQENVE
CCCCCCCCCCCCCCC		34.6628551015
570PhosphorylationRRMPRSNSQENVEAS
CCCCCCCCCCCCCCC		39.8730411139
577PhosphorylationSQENVEASHPSQDAK
CCCCCCCCCCCHHHH		23.5628551015
580PhosphorylationNVEASHPSQDAKRQY
CCCCCCCCHHHHHHH		34.9628551015
629PhosphorylationGINPEDLSQKEYSDL
CCCHHHCCHHHHHHH		52.07-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APBA1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APBA1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APBA1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STXB1_RATStxbp1physical
9395480
STX1A_RATStx1aphysical
9395480
SNP25_RATSnap25physical
9395480
CSKP_RATCaskphysical
9753324
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APBA1_RAT

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Related Literatures of Post-Translational Modification

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