STXB1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STXB1_RAT
• UniProt AC: P61765
• Protein Name: Syntaxin-binding protein 1
• Gene Name: Stxbp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 594
• Subcellular Localization: Cytoplasm, cytosol . Membrane; Peripheral membrane protein.
• Protein Description: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions..
• Protein Sequence: MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MAPIGLKAVVGEKI -CCCCCCHHHHCHHH	33.64	22902405
13	Acetylation	LKAVVGEKIMHDVIK CHHHHCHHHHHHHHH	39.13	22902405
13	Ubiquitination	LKAVVGEKIMHDVIK CHHHHCHHHHHHHHH	39.13	-
20	Acetylation	KIMHDVIKKVKKKGE HHHHHHHHHHHHCCC	51.90	22902405
92	Acetylation	HSLISDFKDPPTAKY HHHHHCCCCCCCCCC	74.45	22902405
92	Ubiquitination	HSLISDFKDPPTAKY HHHHHCCCCCCCCCC	74.45	-
98	Acetylation	FKDPPTAKYRAAHVF CCCCCCCCCEEEEEE	37.43	22902405
110	S-nitrosylation	HVFFTDSCPDALFNE EEEECCCCHHHHHHH	3.83	22178444
110	S-nitrosocysteine	HVFFTDSCPDALFNE EEEECCCCHHHHHHH	3.83	-
120	Acetylation	ALFNELVKSRAAKVI HHHHHHHHHHHHHHH	47.01	140591
120	Ubiquitination	ALFNELVKSRAAKVI HHHHHHHHHHHHHHH	47.01	-
158	Phosphorylation	DSFQSFYSPHKAQMK HHHHHHCCCCHHHCC	20.65	30240740
184	Ubiquitination	ATLCATLKEYPAVRY HHHHHHHHHCCCCEE	51.34	-
294	Ubiquitination	LWIALRHKHIAEVSQ EEHHHHCHHHHHHCH	30.21	-
294	Acetylation	LWIALRHKHIAEVSQ EEHHHHCHHHHHHCH	30.21	22902405
306	Phosphorylation	VSQEVTRSLKDFSSS HCHHHHHHHHHCCCC	30.33	16997485
308	Acetylation	QEVTRSLKDFSSSKR HHHHHHHHHCCCCCC	58.95	22902405
308	Ubiquitination	QEVTRSLKDFSSSKR HHHHHHHHHCCCCCC	58.95	-
313	Phosphorylation	SLKDFSSSKRMNTGE HHHHCCCCCCCCCCC	24.08	16997485
321	Ubiquitination	KRMNTGEKTTMRDLS CCCCCCCCCCHHHHH	51.11	-
328	Phosphorylation	KTTMRDLSQMLKKMP CCCHHHHHHHHHHCH	20.17	28432305
332	Acetylation	RDLSQMLKKMPQYQK HHHHHHHHHCHHHHH	41.50	22902405
339	Acetylation	KKMPQYQKELSKYST HHCHHHHHHHHHHHH	56.54	22902405
364	Ubiquitination	HYQGTVDKLCRVEQD HCCCHHHHHHHHHHH	45.19	-
382	Acetylation	GTDAEGEKIKDPMRA CCCCCCCCCCCHHHH	66.95	22902405
384	Acetylation	DAEGEKIKDPMRAIV CCCCCCCCCHHHHHH	67.84	22902405
411	Phosphorylation	KIRIILLYIFLKNGI HHHHHHHHHHHHCCC	6.03	-
452	Phosphorylation	HLGVPIVTDSTLRRR HHCCCEECHHHHHHC	25.59	25403869
454	Phosphorylation	GVPIVTDSTLRRRSK CCCEECHHHHHHCCC	21.70	25403869
455	Phosphorylation	VPIVTDSTLRRRSKP CCEECHHHHHHCCCH	27.39	25403869
473	Phosphorylation	ERISEQTYQLSRWTP HHHHHHHHHHHCCCH	13.72	22276854
476	Phosphorylation	SEQTYQLSRWTPIIK HHHHHHHHCCCHHHH	15.39	22673903
483	Ubiquitination	SRWTPIIKDIMEDTI HCCCHHHHHHHHHHH	41.75	-
493	Acetylation	MEDTIEDKLDTKHYP HHHHHHHCCCCCCCC	35.16	22902405
493	Ubiquitination	MEDTIEDKLDTKHYP HHHHHHHCCCCCCCC	35.16	-
497	Acetylation	IEDKLDTKHYPYIST HHHCCCCCCCCCEEE	40.59	22902405
497	Ubiquitination	IEDKLDTKHYPYIST HHHCCCCCCCCCEEE	40.59	-
499	Phosphorylation	DKLDTKHYPYISTRS HCCCCCCCCCEEECC	10.17	26022182
501	Phosphorylation	LDTKHYPYISTRSSA CCCCCCCCEEECCCC	10.59	26022182
506	Phosphorylation	YPYISTRSSASFSTT CCCEEECCCCCCCCC	30.28	25403869
507	Phosphorylation	PYISTRSSASFSTTA CCEEECCCCCCCCCC	25.33	30411139
509	Phosphorylation	ISTRSSASFSTTAVS EEECCCCCCCCCCCH	22.98	25403869
511	Phosphorylation	TRSSASFSTTAVSAR ECCCCCCCCCCCHHC	23.50	28432305
512	Phosphorylation	RSSASFSTTAVSARY CCCCCCCCCCCHHCC	19.43	26022182
513	Phosphorylation	SSASFSTTAVSARYG CCCCCCCCCCHHCCC	24.70	28432305
516	Phosphorylation	SFSTTAVSARYGHWH CCCCCCCHHCCCCCC	12.45	28432305
531	Phosphorylation	KNKAPGEYRSGPRLI CCCCCCCCCCCCEEE	18.92	25403869
533	Phosphorylation	KAPGEYRSGPRLIIF CCCCCCCCCCEEEEE	52.85	25403869
574	Phosphorylation	IGSTHILTPQKLLDT EECCEECCHHHHHHH	24.07	15489225
581	Phosphorylation	TPQKLLDTLKKLNKT CHHHHHHHHHHHCCC	40.21	25403869
583	Acetylation	QKLLDTLKKLNKTDE HHHHHHHHHHCCCHH	58.25	22902405
590 (in isoform 2)	Phosphorylation	-	63.56	28432305
591 (in isoform 2)	Phosphorylation	-	51.48	28432305
593	Phosphorylation	NKTDEEISS------ CCCHHHHCC------	33.02	30240740
594	Phosphorylation	KTDEEISS------- CCHHHHCC-------	50.32	30240740
594 (in isoform 2)	Phosphorylation	-	50.32	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
158	S	Phosphorylation	Kinase	CDK5	Q03114	GPS
306	S	Phosphorylation	Kinase	PKCA	P04409	PSP
306	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
306	S	Phosphorylation	Kinase	PKCA	P05696	PSP
313	S	Phosphorylation	Kinase	PKCA	P04409	PSP
313	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
313	S	Phosphorylation	Kinase	PKCA	P05696	PSP
574	T	Phosphorylation	Kinase	CDK5	Q03114	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STXB1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STXB1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX1A_RAT	Stx1a	physical	7768895
STX3_RAT	Stx3	physical	7768895
STX2_RAT	Stx2	physical	7768895

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.