VGFR1_MOUSE - dbPTM
VGFR1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VGFR1_MOUSE
UniProt AC P35969
Protein Name Vascular endothelial growth factor receptor 1
Gene Name Flt1
Organism Mus musculus (Mouse).
Sequence Length 1333
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis..
Protein Description Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity)..
Protein Sequence MVSCWDTAVLPYALLGCLLLTGYGSGSKLKVPELSLKGTQHVMQAGQTLFLKCRGEAAHSWSLPTTVSQEDKRLSITPPSACGRDNRQFCSTLTLDTAQANHTGLYTCRYLPTSTSKKKKAESSIYIFVSDAGSPFIEMHTDIPKLVHMTEGRQLIIPCRVTSPNVTVTLKKFPFDTLTPDGQRITWDSRRGFIIANATYKEIGLLNCEATVNGHLYQTNYLTHRQTNTILDVQIRPPSPVRLLHGQTLVLNCTATTELNTRVQMSWNYPGKATKRASIRQRIDRSHSHNNVFHSVLKINNVESRDKGLYTCRVKSGSSFQSFNTSVHVYEKGFISVKHRKQPVQETTAGRRSYRLSMKVKAFPSPEIVWLKDGSPATLKSARYLVHGYSLIIKDVTTEDAGDYTILLGIKQSRLFKNLTATLIVNVKPQIYEKSVSSLPSPPLYPLGSRQVLTCTVYGIPRPTITWLWHPCHHNHSKERYDFCTENEESFILDPSSNLGNRIESISQRMTVIEGTNKTVSTLVVADSQTPGIYSCRAFNKIGTVERNIKFYVTDVPNGFHVSLEKMPAEGEDLKLSCVVNKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEDILRKTEVLVRDSEAPHLLQNLSDYEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTEEDEGVYRCRATNQKGAVESAAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKLGDLLQANVQQDGKDYIPLNAILTRNSSFTYSTPTFSEDLFKDGFADPHFHSGSSDDVRYVNAFKFMSLERIKTFEELSPNSTSMFEDYQLDTSTLLGSPLLKRFTWTETKPKASMKIDLRIASKSKEAGLSDLPRPSFCFSSCGHIRPVQDDESELGKESCCSPPPDYNSVVLYSSPPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
101N-linked_GlycosylationTLDTAQANHTGLYTC
EECHHHHCCCCEEEE		22.60-
165N-linked_GlycosylationPCRVTSPNVTVTLKK
EEEECCCCEEEEEEE		41.69-
197N-linked_GlycosylationRRGFIIANATYKEIG
CCCEEEECCEEEEEC		23.54-
200PhosphorylationFIIANATYKEIGLLN
EEEECCEEEEECEEE		12.29-
252N-linked_GlycosylationHGQTLVLNCTATTEL
CCCEEEEECEEECCC		17.39-
324N-linked_GlycosylationGSSFQSFNTSVHVYE
CCCCCEEEEEEEEEE		36.37-
357PhosphorylationGRRSYRLSMKVKAFP
CCCEEEEEEEEEECC		13.9330387612
418N-linked_GlycosylationKQSRLFKNLTATLIV
CHHHCCCCCEEEEEE		34.98-
475N-linked_GlycosylationLWHPCHHNHSKERYD
EECCCCCCCCHHHEE		19.91-
517N-linked_GlycosylationMTVIEGTNKTVSTLV
EEEEECCCCEEEEEE		49.19-
598N-linked_GlycosylationILLRTVNNRTMHHSI
EEEEECCCCHHCCCC		36.14-
626N-linked_GlycosylationTLNLVIKNVSLEDSG
EEEEEEECCCHHHCC		19.93-
667N-linked_GlycosylationEAPHLLQNLSDYEVS
CCCHHHHCCCCCEEE		41.29-
671PhosphorylationLLQNLSDYEVSISGS
HHHCCCCCEEEECCC		18.1722871156
674PhosphorylationNLSDYEVSISGSTTL
CCCCCEEEECCCCEE		10.0922871156
676PhosphorylationSDYEVSISGSTTLDC
CCCEEEECCCCEECH		21.1322871156
714N-linked_GlycosylationGIILGPGNSTLFIER
CEEECCCCCEEEEEE		34.65-
792UbiquitinationKRSSSEVKTDYLSII
HCCCCCCCCCEEEEE		31.4622790023
820UbiquitinationRLPYDASKWEFARER
CCCCCHHHHHHHHHH		53.0822790023
841UbiquitinationLGRGAFGKVVQASAF
CCCCHHHHHHHHHHH		32.5522790023
851UbiquitinationQASAFGIKKSPTCRT
HHHHHCCCCCCCCHH		47.8022790023
865UbiquitinationTVAVKMLKEGATASE
HHHHHHHHCCCCHHH		51.0722790023
869PhosphorylationKMLKEGATASEYKAL
HHHHCCCCHHHHHHH		41.3921454597
871PhosphorylationLKEGATASEYKALMT
HHCCCCHHHHHHHHH		36.7821454597
873PhosphorylationEGATASEYKALMTEL
CCCCHHHHHHHHHHH		10.0821454597
915PhosphorylationVIVEYCKYGNLSNYL
EEEEEECCCCHHHHH		14.0028576409
919PhosphorylationYCKYGNLSNYLKSKR
EECCCCHHHHHHHCH		27.6828576409
921PhosphorylationKYGNLSNYLKSKRDL
CCCCHHHHHHHCHHE		16.4828576409
924PhosphorylationNLSNYLKSKRDLFCL
CHHHHHHHCHHEEEC		30.2628576409
943UbiquitinationALHMELKKESLEPGL
HHHHHHHHHHCCCCH		66.22-
955UbiquitinationPGLEQGQKPRLDSVS
CCHHCCCCCCCCCCC		38.6422790023
976PhosphorylationSSFPEDRSVSDVEGD
CCCCCCCCCCCCCCC		37.99-
978PhosphorylationFPEDRSVSDVEGDED
CCCCCCCCCCCCCCC		36.87-
995PhosphorylationEISKQPLTMEDLISY
HHHCCCCCHHHHHHH		25.7930635358
1001PhosphorylationLTMEDLISYSFQVAR
CCHHHHHHHHHHHHH		23.2530635358
1002PhosphorylationTMEDLISYSFQVARG
CHHHHHHHHHHHHHH		13.4030635358
1003PhosphorylationMEDLISYSFQVARGM
HHHHHHHHHHHHHHC		11.4730635358
1014PhosphorylationARGMEFLSSRKCIHR
HHHCHHHHCCCCHHH		33.1630635358
1015PhosphorylationRGMEFLSSRKCIHRD
HHCHHHHCCCCHHHH		37.6030635358
1048PhosphorylationFGLARDIYKNPDYVR
CCCCCHHHHCCCCCC		14.7022817900
1049UbiquitinationGLARDIYKNPDYVRR
CCCCHHHHCCCCCCC		63.4422790023
1053PhosphorylationDIYKNPDYVRRGDTR
HHHHCCCCCCCCCCC		9.3422817900
1121PhosphorylationKEGMRMRTPEYATPE
HCCCCCCCCCCCCHH		15.8928576409
1124PhosphorylationMRMRTPEYATPEIYQ
CCCCCCCCCCHHHHH		19.5828576409
1126PhosphorylationMRTPEYATPEIYQIM
CCCCCCCCHHHHHHH		22.1328576409
1130PhosphorylationEYATPEIYQIMLDCW
CCCCHHHHHHHHHHH		7.1328576409
1153UbiquitinationRFAELVEKLGDLLQA
HHHHHHHHHHHHHHH		50.7422790023
1169PhosphorylationVQQDGKDYIPLNAIL
HCCCCCCCEEHHHEE		14.1327180971
1184PhosphorylationTRNSSFTYSTPTFSE
ECCCCCCCCCCCCCH		14.45-
1205PhosphorylationFADPHFHSGSSDDVR
CCCCCCCCCCCCCCE		39.1523375375
1207PhosphorylationDPHFHSGSSDDVRYV
CCCCCCCCCCCCEEE		33.3427742792
1208PhosphorylationPHFHSGSSDDVRYVN
CCCCCCCCCCCEEEE		41.1627742792
1213PhosphorylationGSSDDVRYVNAFKFM
CCCCCCEEEEEEEEE		9.63-
1218UbiquitinationVRYVNAFKFMSLERI
CEEEEEEEEEEHHHC		37.4322790023
1242PhosphorylationSTSMFEDYQLDTSTL
CCCCCCCCCCCHHHH		12.08-
1259PhosphorylationSPLLKRFTWTETKPK
CHHHHCEECCCCCCC		35.1917203969
1261PhosphorylationLLKRFTWTETKPKAS
HHHCEECCCCCCCCC		30.6217203969
1263PhosphorylationKRFTWTETKPKASMK
HCEECCCCCCCCCCE		45.3217203969
1322PhosphorylationCCSPPPDYNSVVLYS
CCCCCCCCCCEEEEE		18.34-
1328PhosphorylationDYNSVVLYSSPPA--
CCCCEEEEECCCC--		8.76-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VGFR1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VGFR1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VGFR1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LDLR_MOUSELdlrphysical
17962812
CBL_MOUSECblphysical
15001553
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VGFR1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1263, AND MASSSPECTROMETRY.

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