LDLR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDLR_MOUSE
• UniProt AC: P35951
• Protein Name: Low-density lipoprotein receptor
• Gene Name: Ldlr
• Organism: Mus musculus (Mouse).
• Sequence Length: 862
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Membrane, clathrin-coated pit . Golgi apparatus . Early endosome . Late endosome . Lysosome . Rapidly endocytosed upon ligand binding.
• Protein Description: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits..
• Protein Sequence: MSTADLMRRWVIALLLAAAGVAAEDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPGLSTVASVTVSHQVQGDMAGRGNEEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLKNINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	N-linked_Glycosylation	DGQVDCENDSDEQGC CCEEECCCCCCCCCC	61.49	-
273	N-linked_Glycosylation	SDELGCVNVTQCDGP CCCCCCEEEEECCCC	34.88	-
307	Phosphorylation	ARDCQDWSDEPIKEC CHHCCCCCCCCHHHC	40.15	26525534
421	Phosphorylation	TLDRSEYTSLLPNLK CCCHHHHHHHCCCCC	14.62	28576409
445	Phosphorylation	TNNRIYWSDLSQKKI CCCEEEECCCCHHHH	16.23	29899451
462	N-linked_Glycosylation	ALMDQAPNLSYDTII HHHHCCCCCCCCEEE	44.63	-
725	Phosphorylation	TVLTTQGTSAVRPVV EEEECCCCCCCCCEE	12.05	-
733	Phosphorylation	SAVRPVVTASATRPP CCCCCEEEEECCCCC	18.35	-
735	Phosphorylation	VRPVVTASATRPPKH CCCEEEEECCCCCCC	22.32	-
822	Phosphorylation	WRLKNINSINFDNPV CCCCCCCCCCCCCCC	3.18	26643407
830	Phosphorylation	INFDNPVYQKTTEDE CCCCCCCEECCCCCC	28.21	25159016
832	Ubiquitination	FDNPVYQKTTEDELH CCCCCEECCCCCCEE	12.92	-
843	Phosphorylation	DELHICRSQDGYTYP CCEEEEECCCCCCCC	2.08	22499769
847	Phosphorylation	ICRSQDGYTYPSRQM EEECCCCCCCCCCCE	54.00	22499769
848	Phosphorylation	CRSQDGYTYPSRQMV EECCCCCCCCCCCEE	14.72	22499769
849	Phosphorylation	RSQDGYTYPSRQMVS ECCCCCCCCCCCEEE	16.05	22499769
851	Phosphorylation	QDGYTYPSRQMVSLE CCCCCCCCCCEEECC	7.25	22499769
856	Phosphorylation	YPSRQMVSLEDDVA- CCCCCEEECCCCCC-	1.83	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Mylip	Q8BM54	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDLR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDLR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAB1_MOUSE	Dab1	physical	10380922

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.