RTKN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTKN2_HUMAN
• UniProt AC: Q8IZC4
• Protein Name: Rhotekin-2
• Gene Name: RTKN2
• Organism: Homo sapiens (Human).
• Sequence Length: 609
• Protein Description: May play an important role in lymphopoiesis..
• Protein Sequence: MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDDEMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPALVVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	LLSLSTQKDQVLHAV HHHCHHCHHHHHHHH	50.66	29967540
68	Phosphorylation	CNARLMAYTSELQKL HHHHHHHHHHHHHHH	9.24	-
74	Ubiquitination	AYTSELQKLEEQIAN HHHHHHHHHHHHHHH	71.18	-
101	Ubiquitination	ERTACKGKIAISDIR CCCCCCCEEEEEECE	17.92	-
105	Phosphorylation	CKGKIAISDIRIPLM CCCEEEEEECEECEE	20.26	24719451
116	O-linked_Glycosylation	IPLMWKDSDHFSNKE ECEEECCCCCCCCCH	29.29	30379171
120	O-linked_Glycosylation	WKDSDHFSNKERSRR ECCCCCCCCCHHHHH	43.50	30379171
187	Phosphorylation	CTEESSITNTPKKLA CCCCHHCCCCHHHHH	34.68	28348404
189	Phosphorylation	EESSITNTPKKLAKK CCHHCCCCHHHHHHH	28.03	28348404
199	Phosphorylation	KLAKKLKTSISKATG HHHHHHHHHHHHHHC	41.55	30001349
200	Phosphorylation	LAKKLKTSISKATGK HHHHHHHHHHHHHCC	24.23	30001349
202	Phosphorylation	KKLKTSISKATGKKI HHHHHHHHHHHCCCH	18.92	30001349
208	Acetylation	ISKATGKKISSVLQE HHHHHCCCHHHHHCC	49.52	20167786
304	Phosphorylation	QMVEGLISWRRLYCV HHHHHHHHHHHHEEE	21.41	24719451
340	Ubiquitination	ALVVPINKETRIRAM CEEEECCHHHHHEEC	62.27	-
412	Phosphorylation	LMKIEIMSPRKPPLF HHCCEECCCCCCCEE	27.49	20068231
421	Phosphorylation	RKPPLFLTKEATSVY CCCCEEEECCCCCEE	21.36	-
425	Phosphorylation	LFLTKEATSVYHDMS EEEECCCCCEECCCC	21.59	25907765
426	Phosphorylation	FLTKEATSVYHDMSI EEECCCCCEECCCCC	27.94	25907765
428	Phosphorylation	TKEATSVYHDMSIDS ECCCCCEECCCCCCC	7.59	27642862
432	Phosphorylation	TSVYHDMSIDSPMKL CCEECCCCCCCCCCH	29.33	25907765
435	Phosphorylation	YHDMSIDSPMKLESL ECCCCCCCCCCHHHH	25.81	25907765
485	Ubiquitination	HQMVIQKKVLYPASE EEEEEEEEEEEECCC	22.54	29967540
538	Phosphorylation	GKTSVSQTSSLDTKL CCCCHHHHHHHHHHH	16.87	28348404
539	Phosphorylation	KTSVSQTSSLDTKLS CCCHHHHHHHHHHHH	22.67	28348404
540	Phosphorylation	TSVSQTSSLDTKLST CCHHHHHHHHHHHHH	33.38	28348404
571	Phosphorylation	PARRNRLSDGEHTDT CCHHCCCCCCCCCCC	40.09	28102081
576	Phosphorylation	RLSDGEHTDTKTNFE CCCCCCCCCCCCCCC	40.85	29449344
578	Phosphorylation	SDGEHTDTKTNFEAK CCCCCCCCCCCCCCC	40.71	28102081
594	Phosphorylation	VPAPRQKSIKDILDP CCCCCCCCHHHHCCH	26.91	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTKN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTKN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTKN2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RTKN2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.