INT10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT10_MOUSE
• UniProt AC: Q8K2A7
• Protein Name: Integrator complex subunit 10
• Gene Name: Ints10
• Organism: Mus musculus (Mouse).
• Sequence Length: 710
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex..
• Protein Sequence: MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQDSPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQSENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSHIVDPWERLFKILNVVGMRCEWQMDKGRRSCSDLLHRMKELCRYMNSFDSEAHNNYKNQVLYSTMLVFFKSAFQYVSSIQPSLFQGPNAPSQVPLILLEDVANVYGDVEIDRSKHIHKKRKLAEGREKTMSSDDEECSAKGRNRHIVVSKADLSNSIEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSLSQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKPQEEPSKVKPKCRKGLDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDSRDDMALGHVIVLLQQEWPRGENLFLKAISKICQQGNFQYENFFSYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMAVLHRFCINEKILLLQTLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAQGDCEF ------CCCCCHHHH	29.33	30635358
81	Phosphorylation	PVVWREISIITSALR CCCHHHHHHHHHHHH	11.82	-
213	Phosphorylation	YINYVTRSTQSENQH HHHHHCCCCCCCCCC	22.79	25619855
214	Phosphorylation	INYVTRSTQSENQHQ HHHHCCCCCCCCCCC	32.59	25619855
216	Phosphorylation	YVTRSTQSENQHQGA HHCCCCCCCCCCCCC	38.31	25619855
226	Phosphorylation	QHQGAQDTSDLMSPS CCCCCCCHHHHCCCC	16.44	25619855
227	Phosphorylation	HQGAQDTSDLMSPSK CCCCCCHHHHCCCCH	36.72	25619855
231	Phosphorylation	QDTSDLMSPSKRSSQ CCHHHHCCCCHHHCC	33.06	27087446
233	Phosphorylation	TSDLMSPSKRSSQKY HHHHCCCCHHHCCCC	33.13	22942356
236	Phosphorylation	LMSPSKRSSQKYIIE HCCCCHHHCCCCEEE	40.64	29176673
237	Phosphorylation	MSPSKRSSQKYIIEG CCCCHHHCCCCEEEH	34.42	29176673
239	Acetylation	PSKRSSQKYIIEGLT CCHHHCCCCEEEHHC	40.12	23806337
369	Acetylation	RSKHIHKKRKLAEGR CCHHHHHHHHHHHCC	40.37	6568375
379	Phosphorylation	LAEGREKTMSSDDEE HHHCCCCCCCCCHHH	19.96	25521595
381	Phosphorylation	EGREKTMSSDDEECS HCCCCCCCCCHHHHH	35.53	25521595
382	Phosphorylation	GREKTMSSDDEECSA CCCCCCCCCHHHHHH	37.95	25521595
388	Phosphorylation	SSDDEECSAKGRNRH CCCHHHHHHCCCCCE	35.97	30635358
668	Phosphorylation	HTVTRGITKGVKEDF EECCCCCCCCHHHHH	25.27	22871156
672	Acetylation	RGITKGVKEDFRLAM CCCCCCHHHHHHHHH	61.30	7718635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of INT10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.