MARE2_MOUSE - dbPTM
MARE2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MARE2_MOUSE
UniProt AC Q8R001
Protein Name Microtubule-associated protein RP/EB family member 2
Gene Name Mapre2
Organism Mus musculus (Mouse).
Sequence Length 326
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Associated with the microtubule network. Accumulates at the plus end of microtubules (By similarity)..
Protein Description May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity)..
Protein Sequence MPGPTQTLSPNGENNNDIIQDNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPASKPGSTPSRPSSAKRASSSGSASRSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMEVLYASDEQEGQTEEPEAEEQAHDQQPQQQEEY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MPGPTQTLSPNG
---CCCCCCCCCCCC		39.8526745281
7Phosphorylation-MPGPTQTLSPNGEN
-CCCCCCCCCCCCCC		31.5126745281
9PhosphorylationPGPTQTLSPNGENNN
CCCCCCCCCCCCCCC		21.5121082442
24PhosphorylationDIIQDNGTIIPFRKH
CCCCCCCCEEECCCC		23.2222817900
38PhosphorylationHTVRGERSYSWGMAV
CEECCEECEEEEEEE		21.1522871156
48PhosphorylationWGMAVNVYSTSITQE
EEEEEEEEECCCCHH		10.8828576409
53PhosphorylationNVYSTSITQETMSRH
EEEECCCCHHHHCHH		21.8122871156
123PhosphorylationNFKLLQASFKRMNVD
HHHHHHHHHHHCCCC		20.5222817900
125UbiquitinationKLLQASFKRMNVDKV
HHHHHHHHHCCCCCE		48.5222790023
137UbiquitinationDKVIPVEKLVKGRFQ
CCEEEHHHHHCCCCC		59.8322790023
154UbiquitinationLDFIQWFKKFYDANY
CHHHHHHHHHHCCCC		38.73-
155UbiquitinationDFIQWFKKFYDANYD
HHHHHHHHHHCCCCC		39.42-
164UbiquitinationYDANYDGKEYDPVEA
HCCCCCCCCCCCCHH		50.6422790023
166PhosphorylationANYDGKEYDPVEARQ
CCCCCCCCCCCHHCC		29.0925159016
194PhosphorylationIFNLPKKSHHANSPT
HCCCCCCCCCCCCCC		26.9922817900
199PhosphorylationKKSHHANSPTAGAAK
CCCCCCCCCCCCCCC		25.1426824392
201PhosphorylationSHHANSPTAGAAKSS
CCCCCCCCCCCCCCC		37.2322324799
207PhosphorylationPTAGAAKSSPASKPG
CCCCCCCCCCCCCCC		36.5125619855
208PhosphorylationTAGAAKSSPASKPGS
CCCCCCCCCCCCCCC		24.6325619855
211PhosphorylationAAKSSPASKPGSTPS
CCCCCCCCCCCCCCC		42.6525619855
215PhosphorylationSPASKPGSTPSRPSS
CCCCCCCCCCCCCCC		45.7525619855
216PhosphorylationPASKPGSTPSRPSSA
CCCCCCCCCCCCCCC		31.0625619855
218PhosphorylationSKPGSTPSRPSSAKR
CCCCCCCCCCCCCCC		57.8423684622
221PhosphorylationGSTPSRPSSAKRASS
CCCCCCCCCCCCCCC		41.6423684622
222PhosphorylationSTPSRPSSAKRASSS
CCCCCCCCCCCCCCC		40.2623684622
227PhosphorylationPSSAKRASSSGSASR
CCCCCCCCCCCCCCC		29.1223375375
228PhosphorylationSSAKRASSSGSASRS
CCCCCCCCCCCCCCC		37.4222345495
229PhosphorylationSAKRASSSGSASRSD
CCCCCCCCCCCCCCC		33.9822345495
231PhosphorylationKRASSSGSASRSDKD
CCCCCCCCCCCCCCH		25.6422345495
233PhosphorylationASSSGSASRSDKDLE
CCCCCCCCCCCCHHH		33.7322345495
235PhosphorylationSSGSASRSDKDLETQ
CCCCCCCCCCHHHHH		46.6629899451
270UbiquitinationERDFYFGKLREIELL
HHHCHHHHHHHHHHH		34.1822790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
222SPhosphorylationKinaseCDKL5Q3UTQ8
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MARE2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MARE2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MARE2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MARE2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-166, AND MASSSPECTROMETRY.

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