SASH3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SASH3_MOUSE
• UniProt AC: Q8K352
• Protein Name: SAM and SH3 domain-containing protein 3
• Gene Name: Sash3
• Organism: Mus musculus (Mouse).
• Sequence Length: 380
• Protein Description: May function as a signaling adapter protein in lymphocytes..
• Protein Sequence: MLRRKPSNASDKEPTQKKKLSLQRSSSFKDFAKSKPSSPVVSEKEFNLDDNIPEDDSGVLTPEDSGKSGKKLGKKWRAVISRTMNRKMGKMMVKALSEEMGDTLEEGSASPTSPDCSLDSPGPEKMALAFTEQEEREPPSLSRQTSTGSELCSPGPGSGSFLEESPAPQYTGPFCGRARVHTDFTPSPYDHDSLKLQKGDVIQIVEKPPVGTWLGLLNGKLGSFKFIYVDVLPEEAVGPVRPSRRQSKGKRPKPKTLHELLERIGLEEHTSTLLLNGYQTLEDFKELRETHLNELNIMDPQHRAKLLTAAELLLDYDTGSEEAEEGAESSQEPVAHTVSEPKVDIPRDSGCFEGSESGRDEAELAGTEEQLQGLSLSGAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLRRKPSNASDKEP -CCCCCCCCCCCCCC	48.33	24704852
10	Phosphorylation	RRKPSNASDKEPTQK CCCCCCCCCCCCCHH	54.16	24704852
21	Phosphorylation	PTQKKKLSLQRSSSF CCHHHHHHHHCCHHH	31.19	24704852
25	Phosphorylation	KKLSLQRSSSFKDFA HHHHHHCCHHHHHHH	19.85	27742792
26	Phosphorylation	KLSLQRSSSFKDFAK HHHHHCCHHHHHHHH	41.82	27742792
27	Phosphorylation	LSLQRSSSFKDFAKS HHHHCCHHHHHHHHC	37.25	26824392
34	Phosphorylation	SFKDFAKSKPSSPVV HHHHHHHCCCCCCCC	46.50	28833060
37	Phosphorylation	DFAKSKPSSPVVSEK HHHHCCCCCCCCCCE	51.52	23375375
38	Phosphorylation	FAKSKPSSPVVSEKE HHHCCCCCCCCCCEE	30.18	22942356
42	Phosphorylation	KPSSPVVSEKEFNLD CCCCCCCCCEECCCC	43.09	23375375
57	Phosphorylation	DNIPEDDSGVLTPED CCCCCCCCCCCCCCC	43.02	30635358
61	Phosphorylation	EDDSGVLTPEDSGKS CCCCCCCCCCCCCCC	23.40	25266776
65	Phosphorylation	GVLTPEDSGKSGKKL CCCCCCCCCCCCCCC	46.59	22802335
68	Phosphorylation	TPEDSGKSGKKLGKK CCCCCCCCCCCCHHH	60.41	25266776
81	Phosphorylation	KKWRAVISRTMNRKM HHHHHHHHHHHHHHH	18.33	25266776
83	Phosphorylation	WRAVISRTMNRKMGK HHHHHHHHHHHHHHH	16.41	27600695
97	Phosphorylation	KMMVKALSEEMGDTL HHHHHHHHHHHHCHH	36.05	28833060
103	Phosphorylation	LSEEMGDTLEEGSAS HHHHHHCHHHCCCCC	30.27	28833060
108	Phosphorylation	GDTLEEGSASPTSPD HCHHHCCCCCCCCCC	28.93	28833060
110	Phosphorylation	TLEEGSASPTSPDCS HHHCCCCCCCCCCCC	30.33	28833060
112	Phosphorylation	EEGSASPTSPDCSLD HCCCCCCCCCCCCCC	50.85	28833060
113	Phosphorylation	EGSASPTSPDCSLDS CCCCCCCCCCCCCCC	23.33	28833060
117	Phosphorylation	SPTSPDCSLDSPGPE CCCCCCCCCCCCCHH	42.46	28833060
120	Phosphorylation	SPDCSLDSPGPEKMA CCCCCCCCCCHHHCC	36.73	28833060
131	Phosphorylation	EKMALAFTEQEEREP HHCCEEEECHHHCCC	31.02	28285833
140	Phosphorylation	QEEREPPSLSRQTST HHHCCCCCCCCCCCC	50.09	19060867
142	Phosphorylation	EREPPSLSRQTSTGS HCCCCCCCCCCCCCC	27.04	29176673
145	Phosphorylation	PPSLSRQTSTGSELC CCCCCCCCCCCCCCC	27.44	25266776
146	Phosphorylation	PSLSRQTSTGSELCS CCCCCCCCCCCCCCC	23.56	25266776
147	Phosphorylation	SLSRQTSTGSELCSP CCCCCCCCCCCCCCC	48.38	25266776
149	Phosphorylation	SRQTSTGSELCSPGP CCCCCCCCCCCCCCC	27.73	22817900
153	Phosphorylation	STGSELCSPGPGSGS CCCCCCCCCCCCCCC	45.58	27600695
158	Phosphorylation	LCSPGPGSGSFLEES CCCCCCCCCCCCCCC	34.10	29472430
160	Phosphorylation	SPGPGSGSFLEESPA CCCCCCCCCCCCCCC	28.49	27600695
165	Phosphorylation	SGSFLEESPAPQYTG CCCCCCCCCCCCCCC	19.58	29472430
187	Phosphorylation	VHTDFTPSPYDHDSL EECCCCCCCCCCCCC	32.79	28833060
189	Phosphorylation	TDFTPSPYDHDSLKL CCCCCCCCCCCCCEE	30.19	28833060
193	Phosphorylation	PSPYDHDSLKLQKGD CCCCCCCCCEECCCC	24.80	28833060
223	Phosphorylation	LLNGKLGSFKFIYVD HHCCCCCCEEEEEEE	35.38	30387612
243	Phosphorylation	AVGPVRPSRRQSKGK HCCCCCCCHHHCCCC	29.54	22817900
247	Phosphorylation	VRPSRRQSKGKRPKP CCCCHHHCCCCCCCC	41.38	27600695
308	Phosphorylation	QHRAKLLTAAELLLD HHHHHHHHHHHHHHC	33.97	30635358
316	Phosphorylation	AAELLLDYDTGSEEA HHHHHHCCCCCCHHH	18.51	25266776
318	Phosphorylation	ELLLDYDTGSEEAEE HHHHCCCCCCHHHHH	36.06	26824392
320	Phosphorylation	LLDYDTGSEEAEEGA HHCCCCCCHHHHHHH	34.06	27818261
329	Phosphorylation	EAEEGAESSQEPVAH HHHHHHHCCCCCCCC	36.47	27600695
330	Phosphorylation	AEEGAESSQEPVAHT HHHHHHCCCCCCCCC	30.02	27600695
337	Phosphorylation	SQEPVAHTVSEPKVD CCCCCCCCCCCCCCC	18.91	27600695
339	Phosphorylation	EPVAHTVSEPKVDIP CCCCCCCCCCCCCCC	49.70	30635358
349	Phosphorylation	KVDIPRDSGCFEGSE CCCCCCCCCCCCCCC	38.45	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SASH3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SASH3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SASH3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SASH3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.