YTHD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YTHD2_MOUSE
• UniProt AC: Q91YT7
• Protein Name: YTH domain-containing family protein 2 {ECO:0000305}
• Gene Name: Ythdf2 {ECO:0000312|MGI:MGI:2444233}
• Organism: Mus musculus (Mouse).
• Sequence Length: 579
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . Cytoplasm, P-body . Localizes to the cytosol and relocates to the nucleus following heat shock stress.
• Protein Description: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. [PubMed: 28867294 M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing]
• Protein Sequence: MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASSVPKVVGSAVGSGSITSNIVASSSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKERQGRGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSASSLLEQ ------CCHHHHHHH		26824392
2	Acetylation	------MSASSLLEQ ------CCHHHHHHH		-
4	Phosphorylation	----MSASSLLEQRP ----CCHHHHHHHCC		29233185
5	Phosphorylation	---MSASSLLEQRPK ---CCHHHHHHHCCC		30352176
22	Phosphorylation	GNKVQNGSVHQKDGL CCCCCCCCCCCCCCC		-
37	Phosphorylation	NDDDFEPYLSPQARP CCCCCCCCCCCCCCC		18563927
39	Phosphorylation	DDFEPYLSPQARPNN CCCCCCCCCCCCCCC		26824392
196	Phosphorylation	MAALKLGSTEVASSV HHHHHCCCCHHHHCC		26060331
201	Phosphorylation	LGSTEVASSVPKVVG CCCCHHHHCCCEECC		28066266
202	Phosphorylation	GSTEVASSVPKVVGS CCCHHHHCCCEECCC		26824392
277	Phosphorylation	KHNMDIGTWDNKGPV CCCCCCCCCCCCCCC		18846507
300	Phosphorylation	VQNIGQPTQGSPQPV HHHCCCCCCCCCCCC		23140645
303	Phosphorylation	IGQPTQGSPQPVGQQ CCCCCCCCCCCCCCC		23140645
314	Phosphorylation	VGQQANNSPPVAQAS CCCCCCCCCCCCCCC		23140645
321	Phosphorylation	SPPVAQASVGQQTQP CCCCCCCCCCCCCCC		23140645
326	Phosphorylation	QASVGQQTQPLPPPP CCCCCCCCCCCCCCC		23140645
340	Phosphorylation	PPQPAQLSVQQQAAQ CCCCCCCCHHHHHCC		23140645
359	Phosphorylation	VAPRNRGSGFGHNGV ECCCCCCCCCCCCCC		29514104
391	Ubiquitination	EPHPVLEKLRSINNY CCCHHHHHHHCCCCC		-
394	Phosphorylation	PVLEKLRSINNYNPK HHHHHHHCCCCCCCC		27600695
408	Ubiquitination	KDFDWNLKHGRVFII CCCCCCCCCCEEEEE		-
417	Phosphorylation	GRVFIIKSYSEDDIH CEEEEEEECCHHHHH		30635358
418	Phosphorylation	RVFIIKSYSEDDIHR EEEEEEECCHHHHHH		30635358
419	Phosphorylation	VFIIKSYSEDDIHRS EEEEEECCHHHHHHH		23684622
560	Phosphorylation	IFDDFSHYEKRQEEE CCCCCHHHHHHHHHH		25159016
569	Phosphorylation	KRQEEEESVKKERQG HHHHHHHHHHHHHCC		29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YTHD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YTHD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YTHD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of YTHD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.