NOG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOG2_MOUSE
• UniProt AC: Q99LH1
• Protein Name: Nucleolar GTP-binding protein 2
• Gene Name: Gnl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 728
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity)..
• Protein Sequence: MVKPKYKGRSTINRSAASTNPDRVQGAGGQNMRDRGTIRRLNMYRQKERRNSRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQASLQKFQEEMDKVMKDPYKVVMKQSKLPMSLLHDRIQPHNAKVHILDTESFESTFGPKSQRKRPNLFASDMQSLLENAEMSTESYDQGKDRDLVMEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIEAYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKGGEPDMLTVSKMVLNDWQRGRIPFFVKPPNAELPTDSQLPPSSPLEVPTETTQNNPEEETTETEVERSDSITEKEPEGDCSQDRNSEMQQILARVRQNFGKINVGPQFSADDLVPVEMSDLEDLESSGEEEEQEQEQPGEDAEEERSPDTQEEPVGNDTKAVLRALDEKIAKYQRFLNKAKAKKFSAVRISKDLSEKVFAKYKEEKKTSAEDSDAAPTKKARKWDAQMEEEPSNKTQRMLTCKERRRAARQQQSKKVGVRYYETHNVKNRNRNKKKTSDSEGQKHRRNKFRQKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVKPKYKG -------CCCCCCCC	8.68	-
15	Phosphorylation	GRSTINRSAASTNPD CCCCCCCCCCCCCCC	24.57	-
79	Acetylation	ARVEPNIKWFGNTRV EEECCCCCCCCCCHH	43.01	19865119
88	Acetylation	FGNTRVIKQASLQKF CCCCHHHHHHHHHHH	36.63	7712941
324	Phosphorylation	GYPNVGKSSVINTLR CCCCCCCHHHHHHHC	24.73	29899451
325	Phosphorylation	YPNVGKSSVINTLRS CCCCCCHHHHHHHCC	30.42	29899451
329	Phosphorylation	GKSSVINTLRSKKVC CCHHHHHHHCCCCCC	16.66	29899451
476	Phosphorylation	TDSQLPPSSPLEVPT CCCCCCCCCCCCCCC	42.52	25338131
477	Phosphorylation	DSQLPPSSPLEVPTE CCCCCCCCCCCCCCC	39.00	25338131
502	Phosphorylation	TETEVERSDSITEKE CCCEEECCCCCCCCC	23.39	25619855
504	Phosphorylation	TEVERSDSITEKEPE CEEECCCCCCCCCCC	32.43	23684622
506	Phosphorylation	VERSDSITEKEPEGD EECCCCCCCCCCCCC	44.98	25619855
515	Phosphorylation	KEPEGDCSQDRNSEM CCCCCCCCCCCCHHH	39.60	25159016
520	Phosphorylation	DCSQDRNSEMQQILA CCCCCCCHHHHHHHH	35.03	25159016
553	Phosphorylation	DLVPVEMSDLEDLES HCEECCHHHHHHHHH	26.07	25338131
560	Phosphorylation	SDLEDLESSGEEEEQ HHHHHHHHCCCHHHH	51.44	25338131
561	Phosphorylation	DLEDLESSGEEEEQE HHHHHHHCCCHHHHH	40.63	25338131
625	Phosphorylation	KFSAVRISKDLSEKV CCCEEEECCCHHHHH	15.00	29176673
642	Phosphorylation	KYKEEKKTSAEDSDA HHHHHHCCCCCCCCC	44.21	20139300
643	Phosphorylation	YKEEKKTSAEDSDAA HHHHHCCCCCCCCCC	38.24	20139300
647	Phosphorylation	KKTSAEDSDAAPTKK HCCCCCCCCCCCCHH	22.21	26824392
652	Phosphorylation	EDSDAAPTKKARKWD CCCCCCCCHHHHHHH	40.21	26745281
669	Acetylation	MEEEPSNKTQRMLTC CCCCCCHHHHHHHHH	50.82	15613415
677	Acetylation	TQRMLTCKERRRAAR HHHHHHHHHHHHHHH	49.36	15613423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NOG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.