RSBN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSBN1_MOUSE
• UniProt AC: Q80T69
• Protein Name: Lysine-specific demethylase 9 {ECO:0000303|PubMed:28867287}
• Gene Name: Rsbn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 795
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture..
• Protein Sequence: MFRSTRTTDQWRVGERLQCPAGHARAALARTADGGAVGPFKCVFVGEMAAQVGAVRVVRAVAAQEEPDKEGKEKPHVGVSPRGVKRQRRASSGGSQEKRGRPSQDPPLAPPHRRRRSRQHPGPLPPTNAAPTVPGPVEPLLLPPPPPPSLAPAGPTVAAPLPAPGTSALFTFSPLTVSAAGPKHKGHKERHKHHHHRGSDGDPGACVPGDLKHKDKQENGERSGGVPLIKAPKRETADENGKTQRADDFVLKKIKKKKKKKHREDMRGRRLKMYNKEVQTVCAGLTRISKEILTQGQLNSTSGVNKESFRYLKDEQLCRLNLGMQEYRVPQGVQTPFTTHQEHSIRRNFLKTGTKFSNFIHEEHQSNGGALVLHAYMDELSFLSPMEMERFSEEFLALTFSENEKNAAYYALAIVHGAAAYLPDFLDYFAFNFPNTPVKMEILGKKDIETTTISNFHTQVNRTYCCGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKMTLPWGTLSSLQLQCRSQSDDGPIMWVRPGEQMIPTADMPKSPFKRRRSMNEIKNLQYLPRTSEPREVLFEDRTRAHADHVGQGFDWQSTAAVGVLKAVQFGEWSDQPRITKDVICFHAEDFTDVVQRLQLDLHEPPVSQCVQWVDEAKLNQMRREGIRYARIQLCDNDIYFIPRNVIHQFKTVSAVCSLAWHIRLKQYHPVVETAQNTESNSNMDCGLEVDSQCVRIKTESEERCTEMQLLTTASPSFPPPSELHLQDLKTQPLPVFKVESRLDSDQQHSLQAHPSTPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	EKPHVGVSPRGVKRQ CCCCCCCCCHHHHHH	11.71	26824392
91	Phosphorylation	VKRQRRASSGGSQEK HHHHHHHCCCCCCCC	27.92	23684622
199	Phosphorylation	KHHHHRGSDGDPGAC CCCCCCCCCCCCCCC	38.07	28833060
300	Phosphorylation	LTQGQLNSTSGVNKE HHCCCCCCCCCCCHH	32.32	29514104
313	Acetylation	KESFRYLKDEQLCRL HHHHHCCCHHHHHHH	50.73	22826441
541	Phosphorylation	PGEQMIPTADMPKSP CCCCCCCCCCCCCCH	25.10	26745281
547	Phosphorylation	PTADMPKSPFKRRRS CCCCCCCCHHCCCCC	29.69	25266776
554	Phosphorylation	SPFKRRRSMNEIKNL CHHCCCCCHHHHHCC	24.93	24453211
748	Phosphorylation	CTEMQLLTTASPSFP CCCCHHHHCCCCCCC	28.98	22006019
749	Phosphorylation	TEMQLLTTASPSFPP CCCHHHHCCCCCCCC	25.71	26745281
751	Phosphorylation	MQLLTTASPSFPPPS CHHHHCCCCCCCCCC	20.98	26745281
753	Phosphorylation	LLTTASPSFPPPSEL HHHCCCCCCCCCCHH	48.14	26745281
758	Phosphorylation	SPSFPPPSELHLQDL CCCCCCCCHHCHHHC	59.57	26745281
786	Phosphorylation	LDSDQQHSLQAHPST CCCCCCCCCCCCCCC	20.17	25619855
792	Phosphorylation	HSLQAHPSTPV---- CCCCCCCCCCC----	35.16	25619855
793	Phosphorylation	SLQAHPSTPV----- CCCCCCCCCC-----	32.30	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RSBN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSBN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSBN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAPCA_MOUSE	Prkaca	physical	14724137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.