PPR18_MOUSE - dbPTM
PPR18_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPR18_MOUSE
UniProt AC Q8BQ30
Protein Name Phostensin
Gene Name Ppp1r18
Organism Mus musculus (Mouse).
Sequence Length 594
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description May target protein phosphatase 1 to F-actin cytoskeleton..
Protein Sequence MTAIPDWKLQLLARRRQEEAAVRGREKAERDRLSQMPAWKRGILERRRAKLGLPPGEGSPVPGNAEAGPPDPDESAVLLEAIGPVHQNRFIQQERQRQQQQQQQQRNEVLGDRKAGPLEVLERRSSPGNLRDQSPKGRESREERLSPRESRDRRLVIGGAQESSSRSLRDWRQSPAEARDLSSRPAEAQKWRLSPGETPEESLRLAGSGDDSPKRKEVLESILSPGEPGDQKASPTDVHKWNLDSREPQKQSLIQLEATEWRLKSGEERKDYLEGCGREEEKLSSGIVPVTKEVQDITSSEVETAEQRPTESWKWTLNSGKARERTTWDIDTQTQKPDPPASSEKHPGPSGMEAEEEAEKEEAEAQSRPLRAQQNLCSGPSPLPPEHSGTEGSRQQEEEAAEPRPPTPAPLSPPPSAPTAPQPSGDPLMSRLFYGVKPGPGVGAPRRSGHTFTVNPRRCAPPASPAPPVNPATADAAGSGSGKKRYPTAEEILVLGGYLRLSRSCLVKGSPERHHKQLKISFSETALETTYQYPSESSVLEDLGPEPETPIAPLATQPDEEEEEEEEEEELLLQPGLQGGLRTKALIVDESCRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationGLPPGEGSPVPGNAE
CCCCCCCCCCCCCCC		20.5825619855
125PhosphorylationLEVLERRSSPGNLRD
HHHHHCCCCCCCCCC		47.2927087446
126PhosphorylationEVLERRSSPGNLRDQ
HHHHCCCCCCCCCCC		34.7126824392
134PhosphorylationPGNLRDQSPKGRESR
CCCCCCCCCCCCCCH		32.6327087446
134 (in isoform 2)Phosphorylation-32.6319144319
140PhosphorylationQSPKGRESREERLSP
CCCCCCCCHHHHCCC		43.5625266776
146PhosphorylationESREERLSPRESRDR
CCHHHHCCCCHHCCC		28.2926824392
163PhosphorylationVIGGAQESSSRSLRD
EECCCCCCCCHHHHH		22.8729514104
164PhosphorylationIGGAQESSSRSLRDW
ECCCCCCCCHHHHHH		29.0829514104
174PhosphorylationSLRDWRQSPAEARDL
HHHHHHHCHHHHHCH		19.9427149854
194 (in isoform 2)Phosphorylation-23.4519144319
194PhosphorylationEAQKWRLSPGETPEE
HHHHCCCCCCCCHHH		23.4527087446
198PhosphorylationWRLSPGETPEESLRL
CCCCCCCCHHHHHHH		41.7527149854
202PhosphorylationPGETPEESLRLAGSG
CCCCHHHHHHHCCCC		19.6828833060
208PhosphorylationESLRLAGSGDDSPKR
HHHHHCCCCCCCHHH		33.1827087446
212 (in isoform 2)Phosphorylation-36.7419144319
212PhosphorylationLAGSGDDSPKRKEVL
HCCCCCCCHHHHHHH		36.7427087446
221PhosphorylationKRKEVLESILSPGEP
HHHHHHHHHHCCCCC		25.3525619855
224PhosphorylationEVLESILSPGEPGDQ
HHHHHHHCCCCCCCC		29.2327087446
234PhosphorylationEPGDQKASPTDVHKW
CCCCCCCCCCCHHHC		35.0526824392
236PhosphorylationGDQKASPTDVHKWNL
CCCCCCCCCHHHCCC		48.4327742792
284PhosphorylationGREEEKLSSGIVPVT
CCCHHHHHCCCEECC		37.2724719451
326PhosphorylationSGKARERTTWDIDTQ
CCCCCCCEEEECCCC		27.7325777480
327PhosphorylationGKARERTTWDIDTQT
CCCCCCEEEECCCCC		27.6225777480
332PhosphorylationRTTWDIDTQTQKPDP
CEEEECCCCCCCCCC		33.5725777480
334PhosphorylationTWDIDTQTQKPDPPA
EEECCCCCCCCCCCC		40.4225777480
342PhosphorylationQKPDPPASSEKHPGP
CCCCCCCCCCCCCCC		44.8225777480
343PhosphorylationKPDPPASSEKHPGPS
CCCCCCCCCCCCCCC		53.4225777480
378PhosphorylationRAQQNLCSGPSPLPP
HHHHHCCCCCCCCCC		57.8325619855
381PhosphorylationQNLCSGPSPLPPEHS
HHCCCCCCCCCCCCC		42.4625619855
388PhosphorylationSPLPPEHSGTEGSRQ
CCCCCCCCCCCCCHH		45.8325619855
390PhosphorylationLPPEHSGTEGSRQQE
CCCCCCCCCCCHHHH		39.9425619855
393PhosphorylationEHSGTEGSRQQEEEA
CCCCCCCCHHHHHHH		22.2325619855
407PhosphorylationAAEPRPPTPAPLSPP
HCCCCCCCCCCCCCC		34.4625619855
412 (in isoform 2)Phosphorylation-34.0119144319
412PhosphorylationPPTPAPLSPPPSAPT
CCCCCCCCCCCCCCC		34.0127087446
416PhosphorylationAPLSPPPSAPTAPQP
CCCCCCCCCCCCCCC		53.2925619855
419PhosphorylationSPPPSAPTAPQPSGD
CCCCCCCCCCCCCCC		51.1625619855
424PhosphorylationAPTAPQPSGDPLMSR
CCCCCCCCCCCCHHH		51.0528285833
434PhosphorylationPLMSRLFYGVKPGPG
CCHHHHHCCCCCCCC		26.1225367039
437AcetylationSRLFYGVKPGPGVGA
HHHHCCCCCCCCCCC		39.6423806337
448PhosphorylationGVGAPRRSGHTFTVN
CCCCCCCCCCCEEEC		35.8818846507
451PhosphorylationAPRRSGHTFTVNPRR
CCCCCCCCEEECHHH		25.2418846507
464PhosphorylationRRCAPPASPAPPVNP
HHCCCCCCCCCCCCH		27.6325619855
479PhosphorylationATADAAGSGSGKKRY
HHCCCCCCCCCCCCC		25.6725266776
481PhosphorylationADAAGSGSGKKRYPT
CCCCCCCCCCCCCCC		49.4925266776
486PhosphorylationSGSGKKRYPTAEEIL
CCCCCCCCCCHHHHH		17.5126745281
488PhosphorylationSGKKRYPTAEEILVL
CCCCCCCCHHHHHHH		37.4526745281
504PhosphorylationGYLRLSRSCLVKGSP
HHHHHCHHHEECCCH		14.3928833060
510PhosphorylationRSCLVKGSPERHHKQ
HHHEECCCHHHHHCE		20.1926824392
510 (in isoform 2)Phosphorylation-20.1919144319
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPR18_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPR18_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPR18_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PPR18_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPR18_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND SER-510, ANDMASS SPECTROMETRY.

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