APC7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APC7_MOUSE
• UniProt AC: Q9WVM3
• Protein Name: Anaphase-promoting complex subunit 7
• Gene Name: Anapc7
• Organism: Mus musculus (Mouse).
• Sequence Length: 565
• Protein Description: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)..
• Protein Sequence: MSVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPSQKYQLLVYHADSLFHDKEYRNAVSKYAMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKLDKDAIAVLDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDSKNSVLKFEQAQMLDPYLIRGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALAQRPDYVKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
146	Ubiquitination	MMLANLYKKAGQERP HHHHHHHHHHCCCCC	39.04	22790023
156	Phosphorylation	GQERPSVTSYKEVLR CCCCCCCCCHHHHHH	30.58	25338131
157	Phosphorylation	QERPSVTSYKEVLRQ CCCCCCCCHHHHHHH	31.86	25338131
158	Phosphorylation	ERPSVTSYKEVLRQC CCCCCCCHHHHHHHC	11.21	25338131
229	Acetylation	NTICSLEKKSLLRDN HHHHHHHHHHHHCCC	53.61	23806337
229	Malonylation	NTICSLEKKSLLRDN HHHHHHHHHHHHCCC	53.61	26320211
259	Ubiquitination	DSKNSVLKFEQAQML CCCCCEEHHHHHHCC	44.70	22790023
433	Ubiquitination	KAKTLLDKALAQRPD HHHHHHHHHHHCCCH	45.31	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APC7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APC7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APC7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of APC7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.