HELZ_MOUSE - dbPTM
HELZ_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HELZ_MOUSE
UniProt AC Q6DFV5
Protein Name Probable helicase with zinc finger domain
Gene Name Helz
Organism Mus musculus (Mouse).
Sequence Length 1964
Subcellular Localization Nucleus .
Protein Description May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo..
Protein Sequence MEDRRAERSCEQACASLQRQDYDMALQHCTDALLSLGQYSMADFTGPCPVEVERIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGERAFRAVLCCMQLKGKLQLVSSILAKSLSGESLNGMVTKDLTRLKTLLTETETATSNVLSGCHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKRQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQARLHDLLYIEEIAQYKEVSRFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISRECCEELSLRPDCDIQVELQFQLNRLPLCEMHYALDRIKDNAVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAAKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSTQSTFQMPQKEDILKHRVVVVTLSTSQYLCQLDLEPGFFTHVLLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGNSSRQQQSPPKVKSLYHPQSDHFQSDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVSLGQPQSQHAEKDQQEQNRNGKTDTNNPGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPGVVYSNTKFPRKDHLNPRHINNLPLPAPHAQYAIPSRHFHPLPQLPRPPFPASQPHTLLNQQQNNLPEQPNQMAPQPNQVAPQPNQMTPQPNQVAPQPNQVVQQQSQAPPQAPQPAPQLSPAFQAGPTNAFFNNAVAHRPQSPAAEAVGPEQPPPPGLPDGHSPLRAITQPGPILASPLNNFVDESSPGLPIEEALDGVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHHHHPHLPHLPHTPIGLHQPPVRAEWKVAGRADDETETTFSRFQDLLRELSHRDQGDTGELAEMPPPQSRLLQYRQVQPRSPPAVPSPPSSTDHSSQFANFNDSSRDIEVANSPAFPQRLPPQLFGSPFSLPSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQNHQHAAGQEPFHPLSSRTVSASSLPSLEEYEPRGPGRPLYQRRISSSSAQPCVEEASAPQDSLAQGKESQGHSNPPAFNFPAPESWANTTSSAPYQNIPCNGSSRTSQPRELIAPPKTVKPPEDQLKPESGEVSSSFNYSMLQHLGQFPPLMPNKQIAESANCSSQQSPAGSKPAMSYASALRAPPKPRPPPEQAKKGSDPLSLLQELSLGSSPGSNGFYSYFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationVERIKIESLLYRIAS
EEEEEHHHHHHHHHH		27.44-
113PhosphorylationGKLQLVSSILAKSLS
HHHHHHHHHHHHHCC		17.7225338131
248PhosphorylationEKWMSSLSPEKVLSE
HHHHHCCCHHHHHHH		32.72-
555PhosphorylationQGTKEKVYEATIEEK
CCCCCEEEEEEHHHH		15.7721659604
558PhosphorylationKEKVYEATIEEKTKD
CCEEEEEEHHHHHCC		19.5821659604
563PhosphorylationEATIEEKTKDYVFLR
EEEHHHHHCCEEEEE		32.2129895711
566PhosphorylationIEEKTKDYVFLRISR
HHHHHCCEEEEEECH		8.4829895711
580PhosphorylationRECCEELSLRPDCDI
HHHHHHHCCCCCCCE		26.1325159016
827PhosphorylationAGDHMQLSPFVYSEF
CCCCHHCCHHHHHHH		10.2121454597
1126PhosphorylationNSSRQQQSPPKVKSL
CCCCCCCCCCCCHHC		38.5424453211
1162PhosphorylationIGNPIRAYTPPPPLG
ECCCEEECCCCCCCC		15.2128833060
1163PhosphorylationGNPIRAYTPPPPLGP
CCCEEECCCCCCCCC		28.4726824392
1177PhosphorylationPHPNLGKSPSPVQRI
CCCCCCCCCCCCCCC		28.8922817900
1179PhosphorylationPNLGKSPSPVQRIDP
CCCCCCCCCCCCCCC		44.8125521595
1245MethylationNLLHTHGRGSPIPYG
CCHHHCCCCCCCCCC		34.51-
1247PhosphorylationLHTHGRGSPIPYGLG
HHHCCCCCCCCCCCC		20.4925338131
1296PhosphorylationPEINKIRTPEKKPTE
CCCCCCCCCCCCCCC		38.9922006019
1311PhosphorylationPKQVDLESNPQNRSP
CCCCCCCCCCCCCCC		62.1924453211
1317PhosphorylationESNPQNRSPESRPGV
CCCCCCCCCCCCCCC		40.3427149854
1318PhosphorylationSNPQNRSPESRPGVV
CCCCCCCCCCCCCCE		40.1024719451
1320PhosphorylationPQNRSPESRPGVVYS
CCCCCCCCCCCCEEC		47.3526745281
1326PhosphorylationESRPGVVYSNTKFPR
CCCCCCEECCCCCCC		8.1926745281
1327PhosphorylationSRPGVVYSNTKFPRK
CCCCCEECCCCCCCC		26.8118846507
1329PhosphorylationPGVVYSNTKFPRKDH
CCCEECCCCCCCCCC		28.2818846507
1354PhosphorylationLPAPHAQYAIPSRHF
CCCCCCCCCCCCCCC		13.79-
1464PhosphorylationAVAHRPQSPAAEAVG
CCCCCCCCHHHHCCC		21.1328066266
1499PhosphorylationQPGPILASPLNNFVD
CCCCCEECCCHHCCC		26.8626643407
1508PhosphorylationLNNFVDESSPGLPIE
CHHCCCCCCCCCCHH		37.0526643407
1509PhosphorylationNNFVDESSPGLPIEE
HHCCCCCCCCCCHHH		22.4226643407
1591PhosphorylationAGRADDETETTFSRF
CCCCCCCCHHHHHHH		45.7025195567
1636PhosphorylationYRQVQPRSPPAVPSP
EEECCCCCCCCCCCC		41.7526824392
1642PhosphorylationRSPPAVPSPPSSTDH
CCCCCCCCCCCCCCC		42.7327742792
1645PhosphorylationPAVPSPPSSTDHSSQ
CCCCCCCCCCCCHHH		49.6125159016
1646PhosphorylationAVPSPPSSTDHSSQF
CCCCCCCCCCCHHHC		43.5625159016
1647PhosphorylationVPSPPSSTDHSSQFA
CCCCCCCCCCHHHCC		41.9125159016
1650PhosphorylationPPSSTDHSSQFANFN
CCCCCCCHHHCCCCC		28.7525293948
1651PhosphorylationPSSTDHSSQFANFND
CCCCCCHHHCCCCCC		26.3725293948
1659PhosphorylationQFANFNDSSRDIEVA
HCCCCCCCCCCEEEC		28.5125293948
1660PhosphorylationFANFNDSSRDIEVAN
CCCCCCCCCCEEECC		36.5125293948
1668O-linked_GlycosylationRDIEVANSPAFPQRL
CCEEECCCCCCCCCC		14.1030059200
1668PhosphorylationRDIEVANSPAFPQRL
CCEEECCCCCCCCCC		14.1028066266
1758PhosphorylationFHPLSSRTVSASSLP
CCCCCCCCCCHHHCC		22.2925619855
1760PhosphorylationPLSSRTVSASSLPSL
CCCCCCCCHHHCCCH		23.0921082442
1762PhosphorylationSSRTVSASSLPSLEE
CCCCCCHHHCCCHHH		25.5425619855
1763PhosphorylationSRTVSASSLPSLEEY
CCCCCHHHCCCHHHC		43.9723527152
1766PhosphorylationVSASSLPSLEEYEPR
CCHHHCCCHHHCCCC		54.4225619855
1770PhosphorylationSLPSLEEYEPRGPGR
HCCCHHHCCCCCCCC		23.1225619855
1785PhosphorylationPLYQRRISSSSAQPC
CCCHHHCCCCCCCCC		23.5025521595
1786PhosphorylationLYQRRISSSSAQPCV
CCHHHCCCCCCCCCC		26.4121082442
1787PhosphorylationYQRRISSSSAQPCVE
CHHHCCCCCCCCCCH		23.9322942356
1788PhosphorylationQRRISSSSAQPCVEE
HHHCCCCCCCCCCHH		32.6327087446
1789PhosphorylationRRISSSSAQPCVEEA
HHCCCCCCCCCCHHC		21.2024719451
1797PhosphorylationQPCVEEASAPQDSLA
CCCCHHCCCCCCHHH		43.7025619855
1952PhosphorylationLQELSLGSSPGSNGF
HHHHHCCCCCCCCCC		38.3626745281
1953PhosphorylationQELSLGSSPGSNGFY
HHHHCCCCCCCCCCC		31.3326745281
1956PhosphorylationSLGSSPGSNGFYSYF
HCCCCCCCCCCCCCC		36.8426745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HELZ_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HELZ_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HELZ_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HELZ_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HELZ_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1788, AND MASSSPECTROMETRY.

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