CDA7L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDA7L_MOUSE
• UniProt AC: Q922M5
• Protein Name: Cell division cycle-associated 7-like protein
• Gene Name: Cdca7l
• Organism: Mus musculus (Mouse).
• Sequence Length: 438
• Subcellular Localization: Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction (By similarity)..
• Protein Description: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1..
• Protein Sequence: MELATRSQIPKEVADIFSAPSDDEEFVGFQDDVPMQNLSESCGSLDSRELEKQQNVCFRSKYFTEELRRIFKEDTDSEMEDFEGFTESELNMSSNPELMESELSDSDKAYPVMNDAEEDDEEEAAPRRGRSTRRSSFGLRVAFQFPTKKLARTPDKDSSHLLDSKTDLRRKKSSRQPKGKEDSASDAEDESRAESQENSDALLKRAMNIKENKAMLAQLLAELNSVPDFFPVRTPPSASRRRTPRRAFSEGQITRRMNPTRSARPPEKFALENFTFSATKLTEELYSFRRRKTISGGKCQTYRRHRISSFRSVKDITEEDLENIAITVRDKVYDKVLGNTCHQCRQKTIDTKTVCRNQSCGGVRGQFCGPCLRNRYGEDVRTALLDPKWTCPPCRGICNCSYCRRRDGRCATGILIHLAKFYGYDNVKEYLESLQKQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MELATRSQIPKE ---CCCCCHHCCCHH	43.40	21149613
7	Phosphorylation	-MELATRSQIPKEVA -CCCCCHHCCCHHHH	28.27	21149613
18	Phosphorylation	KEVADIFSAPSDDEE HHHHHHHCCCCCCCC	39.34	21149613
21	Phosphorylation	ADIFSAPSDDEEFVG HHHHCCCCCCCCCCC	58.36	21149613
75	Phosphorylation	RRIFKEDTDSEMEDF HHHHHHCCCCCCCCC	42.38	-
77	Phosphorylation	IFKEDTDSEMEDFEG HHHHCCCCCCCCCCC	40.72	-
86	Phosphorylation	MEDFEGFTESELNMS CCCCCCCCHHHHCCC	49.84	-
101	Phosphorylation	SNPELMESELSDSDK CCHHHHHHHHCCCCC	29.85	-
104	Phosphorylation	ELMESELSDSDKAYP HHHHHHHCCCCCCCC	30.89	-
135	Phosphorylation	RGRSTRRSSFGLRVA CCCCHHHHCCCCEEE	27.08	25159016
136	Phosphorylation	GRSTRRSSFGLRVAF CCCHHHHCCCCEEEE	22.86	22942356
153	Phosphorylation	PTKKLARTPDKDSSH CCCCCCCCCCCCCHH	30.17	28973931
158	Phosphorylation	ARTPDKDSSHLLDSK CCCCCCCCHHHCCCH	25.95	25777480
159	Phosphorylation	RTPDKDSSHLLDSKT CCCCCCCHHHCCCHH	28.43	25777480
164	Phosphorylation	DSSHLLDSKTDLRRK CCHHHCCCHHHHHHH	37.11	25777480
180	Acetylation	SSRQPKGKEDSASDA HCCCCCCCCCCCCHH	65.56	19861653
183	Phosphorylation	QPKGKEDSASDAEDE CCCCCCCCCCHHHHH	30.66	21082442
185	Phosphorylation	KGKEDSASDAEDESR CCCCCCCCHHHHHHH	41.11	21082442
195	Phosphorylation	EDESRAESQENSDAL HHHHHHHHHHCHHHH	41.64	25266776
225	Phosphorylation	QLLAELNSVPDFFPV HHHHHHCCCCCCCCC	47.88	26745281
234	Phosphorylation	PDFFPVRTPPSASRR CCCCCCCCCCCCCCC	39.52	20139300
237	Phosphorylation	FPVRTPPSASRRRTP CCCCCCCCCCCCCCC	39.83	26745281
239	Phosphorylation	VRTPPSASRRRTPRR CCCCCCCCCCCCCCH	30.56	26745281
249	Phosphorylation	RTPRRAFSEGQITRR CCCCHHCCCCCCCCC	39.57	28833060
277	Phosphorylation	ALENFTFSATKLTEE CCCCCEEEHHHHHHH	31.78	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDA7L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDA7L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDA7L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CDA7L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.