dbPTM

TRI56_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRI56_MOUSE
UniProt AC	Q80VI1
Protein Name	E3 ubiquitin-protein ligase TRIM56
Gene Name	Trim56
Organism	Mus musculus (Mouse).
Sequence Length	734
Subcellular Localization	Cytoplasm .
Protein Description	E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity)..
Protein Sequence	MNSKVSSPTLLEALSSDFLACKICLEQLHTPKTLPCLHTYCQDCLAQLDIGGQVRCPECREIVPVPAEGVAAFKTNFFVNGLLDLVKARAPGDVHSGKPTCALCPLVGGKSSGGPATARCLDCADDLCQACADGHRCSRQTHKHRVVDLVGYRAGWYDEEARERQASQCPQHPGEALCFLCQPCSQLLCKDCRLGPHIDHPCLPLAEAVRSRKPGLEELLAGVDSNLVELEATRVAEKEALALLREQAASVGTQVEEAAERILKSLLAQKQEVLGQLRALVEAAEEATRERLTKIERQEQVAKAAAAFARRVLSLGLEAEILSLEGAITQRLRQLQDAPWTSGPTRCVLPQLELHPGLEDKNCHLLRLIFEEPKQSPKDSGKGGAGTQGGDEAQGQGDDRTKIGKQGGAQPLTPKEGKDQNPQEDDGVFIERGNRPNKKKKCKGRGKSVSREPSPILRPNLEGSGLLPRPVFSWSFPTRMPGDKRSPRITGLCPYGPQEILVADEQNRVLKRFSLNGDYKGTVQVPEGCSPCSVAALQNAVAFSANAKLYLVSPDGEIQWRRSLSLTQSSHAVAAMPCGDRVAVSVAGHVEVYKKDGSLATRFIPGGKASRGQRALVFLTTSPQGNFVGSDWQQNSVVFCDGLGQVIWEYKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYHGLEKPRVTTMVDGKYLVVSLSNGTIHVFRVRFPDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNSKVSSPTLLEA --CCCCCCCHHHHHH	34.04	26745281
7	Phosphorylation	-MNSKVSSPTLLEAL -CCCCCCCHHHHHHH	25.54	26745281
9	Phosphorylation	NSKVSSPTLLEALSS CCCCCCHHHHHHHCC	46.02	26745281
15	Phosphorylation	PTLLEALSSDFLACK HHHHHHHCCCHHHHH	34.60	25777480
16	Phosphorylation	TLLEALSSDFLACKI HHHHHHCCCHHHHHH	32.98	25777480
87	Ubiquitination	NGLLDLVKARAPGDV HCHHHHHHHCCCCCC	39.18	22790023
110	Acetylation	LCPLVGGKSSGGPAT EECCCCCCCCCCCCC	35.20	23806337
270	Ubiquitination	LKSLLAQKQEVLGQL HHHHHHHHHHHHHHH	42.70	22790023
314	Phosphorylation	AFARRVLSLGLEAEI HHHHHHHHHCHHHHH	19.96	17203969
323	Phosphorylation	GLEAEILSLEGAITQ CHHHHHHHHHHHHHH	30.00	-
329	Phosphorylation	LSLEGAITQRLRQLQ HHHHHHHHHHHHHHH	13.70	-
374	Ubiquitination	RLIFEEPKQSPKDSG HHHHCCCCCCCCCCC	67.69	22790023
376	Phosphorylation	IFEEPKQSPKDSGKG HHCCCCCCCCCCCCC	39.79	26824392
380	Phosphorylation	PKQSPKDSGKGGAGT CCCCCCCCCCCCCCC	48.83	24068923
405	Ubiquitination	DDRTKIGKQGGAQPL CCCCCCCCCCCCCCC	49.60	22790023
413	Phosphorylation	QGGAQPLTPKEGKDQ CCCCCCCCCCCCCCC	38.71	24453211
448	Phosphorylation	KCKGRGKSVSREPSP CCCCCCCCCCCCCCC	28.31	26824392
450	Phosphorylation	KGRGKSVSREPSPIL CCCCCCCCCCCCCCC	37.71	26824392
454	Phosphorylation	KSVSREPSPILRPNL CCCCCCCCCCCCCCC	21.59	26824392
464	Phosphorylation	LRPNLEGSGLLPRPV CCCCCCCCCCCCCCE	19.52	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRI56_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRI56_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRI56_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TRI56_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRI56_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448; SER-450 ANDSER-454, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, AND MASSSPECTROMETRY.	17203969 [Abstract]