dbPTM

PDCD4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDCD4_MOUSE
UniProt AC	Q61823
Protein Name	Programmed cell death protein 4
Gene Name	Pdcd4
Organism	Mus musculus (Mouse).
Sequence Length	469
Subcellular Localization	Nucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm (PubMed:12894233). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (By similarity).
Protein Description	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA..
Protein Sequence	MDIENEQTLNVNPTDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASTINEARINAKAKRRLRKNSSRDSGRGDSVSDNGSEAVRSGVAVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMILDLLKSLWKSSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDIENEQT -------CCCCCCCC	12.06	-
8	Phosphorylation	MDIENEQTLNVNPTD CCCCCCCCCCCCCCC	17.70	25293948
14	Phosphorylation	QTLNVNPTDPDNLSD CCCCCCCCCCCCCHH	55.77	23737553
20	Phosphorylation	PTDPDNLSDSLFSGD CCCCCCCHHHCCCCC	31.26	23737553
22	Phosphorylation	DPDNLSDSLFSGDEE CCCCCHHHCCCCCCC	28.12	23737553
25	Phosphorylation	NLSDSLFSGDEENAG CCHHHCCCCCCCCCC	51.10	30352176
33	Phosphorylation	GDEENAGTEEIKNEI CCCCCCCCHHHHHHH	28.21	25293948
67	Phosphorylation	KRRLRKNSSRDSGRG HHHHHHCCCCCCCCC	29.77	27087446
68	Phosphorylation	RRLRKNSSRDSGRGD HHHHHCCCCCCCCCC	49.88	27087446
71	Phosphorylation	RKNSSRDSGRGDSVS HHCCCCCCCCCCCCC	29.31	27087446
76	Phosphorylation	RDSGRGDSVSDNGSE CCCCCCCCCCCCCCH	26.75	25521595
78	Phosphorylation	SGRGDSVSDNGSEAV CCCCCCCCCCCCHHH	29.34	23684622
82	Phosphorylation	DSVSDNGSEAVRSGV CCCCCCCCHHHHCCC	28.74	-
87	Phosphorylation	NGSEAVRSGVAVPTS CCCHHHHCCCCCCCC	30.90	28833060
93	Phosphorylation	RSGVAVPTSPKGRLL HCCCCCCCCCCCCCC	51.57	24925903
94	Phosphorylation	SGVAVPTSPKGRLLD CCCCCCCCCCCCCCC	20.67	24925903
152	Phosphorylation	DDQENCVYETVVLPL CCCCCCEEEEEEEEC	14.21	22817900
229	Phosphorylation	LLSDLCGTVMSTNDV HHHHHHCCCCCHHHH	16.43	29899451
242	Ubiquitination	DVEKSFDKLLKDLPE HHHHHHHHHHHHCHH	54.42	22790023
245	Ubiquitination	KSFDKLLKDLPELAL HHHHHHHHHCHHHHC	68.60	22790023
297	Ubiquitination	QARAALDKATVLLSM HHHHHHHHHHHEEEC	46.97	22790023
303	Phosphorylation	DKATVLLSMSKGGKR HHHHHEEECCCCCCC	19.49	28059163
306	Ubiquitination	TVLLSMSKGGKRKDS HHEEECCCCCCCCCC	64.14	22790023
313	Phosphorylation	KGGKRKDSVWGSGGG CCCCCCCCCCCCCCC	23.86	21082442
317	Phosphorylation	RKDSVWGSGGGQQPV CCCCCCCCCCCCCCH	20.67	27600695
433	S-palmitoylation	LERFVEECFQAGIIS HHHHHHHHHHHCHHH	1.62	28680068
457	Phosphorylation	RGRKRFVSEGDGGRL CCCCCCCCCCCCCCC	32.90	27087446
468	Phosphorylation	GGRLKPESY------ CCCCCCCCC------	44.67	26745281
469	Phosphorylation	GRLKPESY------- CCCCCCCC-------	22.40	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
67	S	Phosphorylation	Kinase	PKB	P31750	Uniprot
67	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot
457	S	Phosphorylation	Kinase	PKB	P31750	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
67	S	Phosphorylation		-
Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDCD4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PDCD4_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDCD4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY.	19367708 [Abstract]

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