NCBP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCBP3_MOUSE
• UniProt AC: Q8BZR9
• Protein Name: Nuclear cap-binding protein subunit 3 {ECO:0000250|UniProtKB:Q53F19}
• Gene Name: Ncbp3 {ECO:0000250|UniProtKB:Q53F19}
• Organism: Mus musculus (Mouse).
• Sequence Length: 615
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth. [PubMed: 26382858]
• Protein Sequence: MAAVRGLRVSVKAEAPAGPALGLPSPEVESGLERGEPEPMEVEEGELEIVPVRRSLKELLPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRAEVNLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDIFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSSLPAQDKMRSRDASEDKSSEKNKKDKQEDSSDDDETEEGEVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEDQDMDADDRVVVEYHEELPGLKQPRERSLSRRSSASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKSIRNPMRADSISTSNIKNRIGNKLPPEKFADVRHLLDEKRQHSCPRPAVSSTKPDIRQRLGKRPYSPEKAFSSNQVVRREPSSDVHSRLGVPRQDVKGLYSDTRERKSGGLWTRLGSTPKTKEKNTKKVDHRASGAEEDDSELQRAWGALIKEKEESRQKKSRLDSLPSLQIEVSRESSSGSEAES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AVRGLRVSVKAEAPA CCCCEEEEEEEECCC		-
12	Acetylation	RGLRVSVKAEAPAGP CCEEEEEEEECCCCC		22826441
25	Phosphorylation	GPALGLPSPEVESGL CCCCCCCCHHHHHCC		27087446
30	Phosphorylation	LPSPEVESGLERGEP CCCHHHHHCCCCCCC		22942356
55	Phosphorylation	EIVPVRRSLKELLPD EEEECCHHHHHHCCC		29176673
67	Phosphorylation	LPDTSRRYENKAGSF CCCCCHHHCCCCCCC		25777480
73	Phosphorylation	RYENKAGSFITGIDV HHCCCCCCCCCCCCC		25777480
76	Phosphorylation	NKAGSFITGIDVTSK CCCCCCCCCCCCCCH		25777480
81	Phosphorylation	FITGIDVTSKEAIEK CCCCCCCCCHHHHHH		25777480
82	Phosphorylation	ITGIDVTSKEAIEKK CCCCCCCCHHHHHHH		25777480
186	Ubiquitination	SSLPAQDKMRSRDAS HCCCHHHHHHCCCCC		-
197	O-linked_Glycosylation	RDASEDKSSEKNKKD CCCCCCCCHHHCHHC		30059200
198	O-linked_Glycosylation	DASEDKSSEKNKKDK CCCCCCCHHHCHHCC		30059200
209	Phosphorylation	KKDKQEDSSDDDETE HHCCCCCCCCCCCCC		21743459
210	Phosphorylation	KDKQEDSSDDDETEE HCCCCCCCCCCCCCC		21743459
215	Phosphorylation	DSSDDDETEEGEVED CCCCCCCCCCCCCCC		21743459
225	Phosphorylation	GEVEDENSSDVELDT CCCCCCCCCCCEEHH		21743459
226	Phosphorylation	EVEDENSSDVELDTL CCCCCCCCCCEEHHH		21743459
232	Phosphorylation	SSDVELDTLSQVEEE CCCCEEHHHHHHHHH		21743459
296	Phosphorylation	GGMKGILSNSWKRRY CCCHHHCCCHHHHHH		29176673
298	Phosphorylation	MKGILSNSWKRRYHS CHHHCCCHHHHHHHH		23140645
382	Phosphorylation	LKQPRERSLSRRSSA CCCCCHHCCCCCCCC		25159016
384	Phosphorylation	QPRERSLSRRSSASS CCCHHCCCCCCCCCC		25159016
387	Phosphorylation	ERSLSRRSSASSSDS HHCCCCCCCCCCCCC		27149854
388	Phosphorylation	RSLSRRSSASSSDSD HCCCCCCCCCCCCCC		27149854
390	Phosphorylation	LSRRSSASSSDSDEM CCCCCCCCCCCCCCC		27149854
391	Phosphorylation	SRRSSASSSDSDEMD CCCCCCCCCCCCCCC		27149854
392	Phosphorylation	RRSSASSSDSDEMDY CCCCCCCCCCCCCCH		27149854
394	Phosphorylation	SSASSSDSDEMDYDL CCCCCCCCCCCCHHH		27149854
399	Phosphorylation	SDSDEMDYDLELKMI CCCCCCCHHHEEEEE		27149854
407	Phosphorylation	DLELKMISTPSPKKS HHEEEEECCCCCCHH		28833060
408	Phosphorylation	LELKMISTPSPKKSM HEEEEECCCCCCHHC		23684622
410	Phosphorylation	LKMISTPSPKKSMKM EEEECCCCCCHHCEE		26824392
439	Phosphorylation	RNPMRADSISTSNIK CCCCCCCCCCCHHHH		28833060
441	Phosphorylation	PMRADSISTSNIKNR CCCCCCCCCHHHHHC		28833060
443	Phosphorylation	RADSISTSNIKNRIG CCCCCCCHHHHHCCC		28833060
494	Phosphorylation	QRLGKRPYSPEKAFS HHHCCCCCCHHHCCC		25367039
495	Phosphorylation	RLGKRPYSPEKAFSS HHCCCCCCHHHCCCC		26824392
511	Phosphorylation	QVVRREPSSDVHSRL CEEECCCCCCHHHHH		29899451
537	Phosphorylation	SDTRERKSGGLWTRL CCCCCCCCCCCCCCC		22006019
542	Phosphorylation	RKSGGLWTRLGSTPK CCCCCCCCCCCCCCC		23984901
546	Phosphorylation	GLWTRLGSTPKTKEK CCCCCCCCCCCCCCC		23984901
547	Phosphorylation	LWTRLGSTPKTKEKN CCCCCCCCCCCCCCC		23984901
563	Phosphorylation	KKVDHRASGAEEDDS CCCCCCCCCCCCCHH		25521595
570	Phosphorylation	SGAEEDDSELQRAWG CCCCCCHHHHHHHHH		25159016
609	Phosphorylation	EVSRESSSGSEAES- EEECCCCCCCCCCC-		25293948
611	Phosphorylation	SRESSSGSEAES--- ECCCCCCCCCCC---		25293948
615	Phosphorylation	SSGSEAES------- CCCCCCCC-------		25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCBP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCBP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCBP3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NCBP3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.