FOXP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXP1_MOUSE
• UniProt AC: P58462
• Protein Name: Forkhead box protein P1
• Gene Name: Foxp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 705
• Subcellular Localization: Nucleus . Not found in the nucleolus.
• Protein Description: Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. [PubMed: 11358962]
• Protein Sequence: MMQESGSETKSNGSAIQNGSSGGNHLLECGALRDTRSNGEAPAVDLGAADLAHVQQQQQQALQVARQLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	GALRDTRSNGEAPAV CCCCCCCCCCCCCCH	51.81	21183079
113	Phosphorylation	QQVSGLKSPKRNDKQ HHHHCCCCCCCCCCC	40.47	21189417
318	Phosphorylation	VHTPKRESLSHEEHP EECCCCCCCCCCCCC	38.92	27717184
320	Phosphorylation	TPKRESLSHEEHPHS CCCCCCCCCCCCCCC	37.82	27717184
327	Phosphorylation	SHEEHPHSHPLYGHG CCCCCCCCCCCCCCC	31.11	25266776
430	Phosphorylation	ASEASPQSLPHTPTT HHCCCCCCCCCCCCC	47.45	25777480
437	Phosphorylation	SLPHTPTTPTAPLTP CCCCCCCCCCCCCCC	21.61	-
439	Phosphorylation	PHTPTTPTAPLTPVT CCCCCCCCCCCCCCC	38.52	25777480
446	O-linked_Glycosylation	TAPLTPVTQGPSVIT CCCCCCCCCCCCEEE	29.07	22517741
453	Phosphorylation	TQGPSVITTTSMHTV CCCCCEEEECCCCCC	23.13	25777480
467	Phosphorylation	VGPIRRRYSDKYNVP CCCCCHHCCCCCCCC	21.29	26160508
468	Phosphorylation	GPIRRRYSDKYNVPI CCCCHHCCCCCCCCC	26.30	21082442
470	Acetylation	IRRRYSDKYNVPISS CCHHCCCCCCCCCCH	32.55	23236377
471	Phosphorylation	RRRYSDKYNVPISSA CHHCCCCCCCCCCHH	26.78	28833060
476	Phosphorylation	DKYNVPISSADIAQN CCCCCCCCHHHHHHC	17.26	28833060
477	Phosphorylation	KYNVPISSADIAQNQ CCCCCCCHHHHHHCH	30.58	28833060
488	Acetylation	AQNQEFYKNAEVRPP HHCHHHHHCCCCCCC	55.81	19861039
500	Phosphorylation	RPPFTYASLIRQAIL CCCCCHHHHHHHHHH	17.57	26370283
641	Phosphorylation	LNGAMEHTNSNESDS HHHHHCCCCCCCCCC	27.34	21183079
643	Phosphorylation	GAMEHTNSNESDSSP HHHCCCCCCCCCCCC	43.03	21183079
646	Phosphorylation	EHTNSNESDSSPGRS CCCCCCCCCCCCCCC	47.22	21183079
649	Phosphorylation	NSNESDSSPGRSPMQ CCCCCCCCCCCCCCC	36.04	24704852
653	Phosphorylation	SDSSPGRSPMQAVHP CCCCCCCCCCCCCCC	30.55	26370283
678	Phosphorylation	EEAEGPLSLVTTANH HHCCCCEEEEEECCC	24.75	28833060
681	Phosphorylation	EGPLSLVTTANHSPD CCCEEEEEECCCCCC	26.03	28833060
682	Phosphorylation	GPLSLVTTANHSPDF CCEEEEEECCCCCCC	20.27	28833060
686	Phosphorylation	LVTTANHSPDFDHDR EEEECCCCCCCCCCC	26.44	28833060
695	Phosphorylation	DFDHDRDYEDEPVNE CCCCCCCCCCCCCCC	26.61	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXP1_MOUSE	Foxp1	physical	20211142
TLE6_MOUSE	Tle6	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.