MCM10_MOUSE - dbPTM
MCM10_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MCM10_MOUSE
UniProt AC Q0VBD2
Protein Name Protein MCM10 homolog
Gene Name Mcm10
Organism Mus musculus (Mouse).
Sequence Length 885
Subcellular Localization Nucleus . Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase (By similarity).
Protein Description Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (By similarity)..
Protein Sequence MDVEEDDLCLLTSLLEENEAVLPCSSEKDKSLSLGDGDPDEFDELFDADGDGESYTEEAGSGEEGKTGNQEERLATLFGDVEDLTDDEVATSKVGNSGPPPAPSQEKTSEELQDELKKLQEQMKSLQEQLKAASIKQPPGTAPLQEPPDSSLQPLLKEKRIRRIQESACFSAELDVPTLPKAKRVARKPKTPAESSSRMRTPAQPLQVSSSFLEPNHSSSSRSSTPSPQAVPGNKCSRTIRNQNTVSPGNSGDRPQQVSQVSVEAFSGLRLRRPRVSSTEMSRKMAGRKLIRLPQIKEKMATENLEETDWVTFGVILRKVTPQSATSGQTFSIWKLNDLHDLTQCVSLFLFGDVHKDLWKTEQGTVIGLLNANPMKPKDGLKEVCLSIDHPQKVLIMGEAMDLGACKAKKKNGEPCTQTVNLHDCEYCQYHIQAQYKKLSAKRTDLQSTFSGGRIPKKFRKGTSLKERLCQDGFYYGGVSSESFAASRAAAIAPKKKVQTTLTNLVVRGTNSIIQETKQKLGIPQKSLSCSEEFRELMALPTFGARNLQKHLARAKASGSSKPAIQSISASALLKQQKQQMLEMRKRRSEDIQKRFLQSSSEVQSPAVPSSSRQAAAQSPRTGAEFPRLEGTATPRMPKLGRGISEGDDVLFFDDSPPPRPKLSAAAEAKKLAAIAKLRAKGQILTKVDPNNTVRKQMDGRAMLGVKERVENSNTVSPEEELEPARKKRREQLAYLESEEFQKILKAKSKHTDILKEAEAELQKSYFEPLVKKEQMEEKMRATREVKCRVVTCRTCTYTHFKPLETCVSEQHNLHWHDGVKRFFKCPCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationDADGDGESYTEEAGS
CCCCCCCCCCCCCCC		42.7725338131
61PhosphorylationSYTEEAGSGEEGKTG
CCCCCCCCCCCCCCC		50.5122668510
85PhosphorylationFGDVEDLTDDEVATS
HCCHHHCCCCCHHHC		54.4426824392
91PhosphorylationLTDDEVATSKVGNSG
CCCCCHHHCCCCCCC		33.9725619855
92PhosphorylationTDDEVATSKVGNSGP
CCCCHHHCCCCCCCC		18.6625619855
104PhosphorylationSGPPPAPSQEKTSEE
CCCCCCCCCCCCHHH		53.7528066266
125PhosphorylationKLQEQMKSLQEQLKA
HHHHHHHHHHHHHHH		29.9125777480
171PhosphorylationIQESACFSAELDVPT
HHHHHCEEECCCCCC		22.2528285833
178PhosphorylationSAELDVPTLPKAKRV
EECCCCCCCCHHHHH		56.3828285833
209PhosphorylationPAQPLQVSSSFLEPN
CCCCCEECHHHCCCC		13.8020139300
218PhosphorylationSFLEPNHSSSSRSST
HHCCCCCCCCCCCCC		38.2620139300
219PhosphorylationFLEPNHSSSSRSSTP
HCCCCCCCCCCCCCC		25.4520139300
223PhosphorylationNHSSSSRSSTPSPQA
CCCCCCCCCCCCCCC		40.2824759943
225PhosphorylationSSSSRSSTPSPQAVP
CCCCCCCCCCCCCCC		29.0919060867
227PhosphorylationSSRSSTPSPQAVPGN
CCCCCCCCCCCCCCC		29.7222817900
245PhosphorylationRTIRNQNTVSPGNSG
HHHCCCCCCCCCCCC		16.7625367039
247PhosphorylationIRNQNTVSPGNSGDR
HCCCCCCCCCCCCCC		25.6725367039
284UbiquitinationSSTEMSRKMAGRKLI
CCHHHHHHHHCCHHH		26.29-
302PhosphorylationQIKEKMATENLEETD
HHHHHHHCCCCCCCC		23.1621454597
312PhosphorylationLEETDWVTFGVILRK
CCCCCCEEEEEEEEE		15.4921454597
382AcetylationMKPKDGLKEVCLSID
CCCCCCHHHHHHCCC		54.3419861075
393AcetylationLSIDHPQKVLIMGEA
HCCCCCCEEEEEEEC		43.3819861083
444PhosphorylationKKLSAKRTDLQSTFS
HHHHCCCCCCHHHHC		40.1128576409
526UbiquitinationQKLGIPQKSLSCSEE
HHHCCCCHHCCCCHH		48.27-
567PhosphorylationSSKPAIQSISASALL
CCCHHHHHHCHHHHH		16.64-
571PhosphorylationAIQSISASALLKQQK
HHHHHCHHHHHHHHH		16.80-
589PhosphorylationLEMRKRRSEDIQKRF
HHHHHHHHHHHHHHH		43.5923737553
599PhosphorylationIQKRFLQSSSEVQSP
HHHHHHHCCCCCCCC		37.6728066266
600PhosphorylationQKRFLQSSSEVQSPA
HHHHHHCCCCCCCCC		19.9828066266
601PhosphorylationKRFLQSSSEVQSPAV
HHHHHCCCCCCCCCC		47.2128066266
605PhosphorylationQSSSEVQSPAVPSSS
HCCCCCCCCCCCCHH		21.7228066266
610PhosphorylationVQSPAVPSSSRQAAA
CCCCCCCCHHHHHHH		34.0528066266
611PhosphorylationQSPAVPSSSRQAAAQ
CCCCCCCHHHHHHHH		24.3828066266
612PhosphorylationSPAVPSSSRQAAAQS
CCCCCCHHHHHHHHC		32.5228066266
645PhosphorylationPKLGRGISEGDDVLF
CCCCCCCCCCCCEEE		38.0528066266
656PhosphorylationDVLFFDDSPPPRPKL
CEEEECCCCCCCCCC		40.9425159016
713PhosphorylationVKERVENSNTVSPEE
CHHHHHCCCCCCHHH		22.0028066266
715PhosphorylationERVENSNTVSPEEEL
HHHHCCCCCCHHHHC		23.3728066266
717PhosphorylationVENSNTVSPEEELEP
HHCCCCCCHHHHCHH		25.2622668510
834PhosphorylationPCGNRTISLDKLPNK
CCCCCEEECHHCCCC		29.8722817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MCM10_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MCM10_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MCM10_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MCM10_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MCM10_MOUSE

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Related Literatures of Post-Translational Modification

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