TAF6L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF6L_MOUSE
• UniProt AC: Q8R2K4
• Protein Name: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
• Gene Name: Taf6l
• Organism: Mus musculus (Mouse).
• Sequence Length: 616
• Subcellular Localization: Nucleus.
• Protein Description: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity)..
• Protein Sequence: MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPLRPAREGDLYFPEDREVSLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYQQVTRAVLGDDPQLMKVALQDLQTNSKIAALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLIRNPHLCLGPYVRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQQILLSLQKVLTDPVRPLCSHYGAVVGLHALGWKAVERVLYPHLPTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGLGGRGYRPAEDLPWDSLLLQESPPGGSSETGFGSGLPPPSGVAGPEDPSSLTLADIYRELYSFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPDSVRKMPQLTASAVVSPQGDESPCGGTLATATAASESRPLPRVHRARGAPRQQGPGAGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPMIGRTGRPARRWALSDYSLYLPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	FVEIPRESVRLMAES HCCCCHHHHHHHHHH	17.51	-
292	Phosphorylation	LYQQILLSLQKVLTD HHHHHHHHHHHHHCC	25.88	22942356
494	Phosphorylation	LTASAVVSPQGDESP CCEEEEECCCCCCCC	12.61	25266776
500	Phosphorylation	VSPQGDESPCGGTLA ECCCCCCCCCCCCCC	30.17	26643407
505	Phosphorylation	DESPCGGTLATATAA CCCCCCCCCCHHHHH	9.86	26643407
508	Phosphorylation	PCGGTLATATAASES CCCCCCCHHHHHCCC	27.88	26643407
510	Phosphorylation	GGTLATATAASESRP CCCCCHHHHHCCCCC	20.57	26643407
513	Phosphorylation	LATATAASESRPLPR CCHHHHHCCCCCCCC	33.37	26643407
515	Phosphorylation	TATAASESRPLPRVH HHHHHCCCCCCCCHH	36.38	26643407
549	Asymmetric dimethylarginine	QKSRFAPRGAPHFRF HHHCCCCCCCCCEEE	50.94	-
549	Methylation	QKSRFAPRGAPHFRF HHHCCCCCCCCCEEE	50.94	24129315
555	Asymmetric dimethylarginine	PRGAPHFRFIIAGRQ CCCCCCEEEEEECCC	20.86	-
555	Methylation	PRGAPHFRFIIAGRQ CCCCCCEEEEEECCC	20.86	24129315
580	Phosphorylation	QTAFPAPYGPSPASR CCCCCCCCCCCHHHH	43.72	28066266
583	Phosphorylation	FPAPYGPSPASRYVQ CCCCCCCCHHHHHHH	28.83	28066266
586	Phosphorylation	PYGPSPASRYVQKLP CCCCCHHHHHHHCCC	27.77	28066266
587	Methylation	YGPSPASRYVQKLPM CCCCHHHHHHHCCCC	37.43	-
587	Asymmetric dimethylarginine	YGPSPASRYVQKLPM CCCCHHHHHHHCCCC	37.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF6L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF6L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF6L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TAF6L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.