dbPTM

TF3C5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TF3C5_MOUSE
UniProt AC	Q8R2T8
Protein Name	General transcription factor 3C polypeptide 5
Gene Name	Gtf3c5
Organism	Mus musculus (Mouse).
Sequence Length	520
Subcellular Localization	Nucleus.
Protein Description	Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity)..
Protein Sequence	MAAAEPDADPKAAIPVDLRRERRLVCVEYPGVVRNEAKMLQTLGGEESVSRIYTDPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRRRGVLGDEAHPQVTFNLEIIGIISTIYKFQGMSDFQYLAVHTEAGGKHVSMYDRVLMRKPEKEEFFHQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYHNPTISGENLIGLSRARRPHNAIFVNFEDTEVPEQPLEAAVQTWKKACTNPIDQKVEEELRKLFDIRPVWSRNAVKSNVSVHPDKLKILLPYMAYYMITGPWRSLWIRFGYDPRKHPDAKIYQVLDFRIRCGMKYGYGSRDMPVKAKRSTYNYSLPITVKKTSNQPGTMHDLKQGLGPSGTDGPRKLTYNKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIVHRNDGTETVCTERDGWCLPKTTDHLRDTMSLMILQTIRSERPALFSNTGKADRGKEQLMFESGEEEEEEEEEEEEEEEDFKPSDGSENEMETEILDYV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAEPDAD ------CCCCCCCCC	18.51	-
146	Phosphorylation	GGKHVSMYDRVLMRK CCEECCHHHHHHCCC	7.97	29514104
182	Phosphorylation	RLDTPVDYFYRPETQ CCCCCCCEECCCCCC	11.62	29514104
200	Phosphorylation	GYHNPTISGENLIGL CCCCCCCCHHHHHCC	42.40	25338131
333	Phosphorylation	GMKYGYGSRDMPVKA CCCCCCCCCCCCEEE	19.34	29514104
347	Phosphorylation	AKRSTYNYSLPITVK EEECCCEEECEEEEE	10.94	29514104
354	Ubiquitination	YSLPITVKKTSNQPG EECEEEEEECCCCCC	41.50	-
382	Phosphorylation	TDGPRKLTYNKYKLK CCCCCCCCCCCEECC	28.25	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TF3C5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TF3C5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TF3C5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TF3C5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TF3C5_MOUSE

Related Literatures of Post-Translational Modification