CBX4_MOUSE - dbPTM
CBX4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CBX4_MOUSE
UniProt AC O55187
Protein Name E3 SUMO-protein ligase CBX4
Gene Name Cbx4
Organism Mus musculus (Mouse).
Sequence Length 551
Subcellular Localization Nucleus . Nucleus speckle .
Protein Description E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3). [PubMed: 16537902 Plays a role in the lineage differentiation of the germ layers in embryonic development]
Protein Sequence MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSADNRAKLELGTQGKGQGHQYELNSKKHHQYQPHSKERSGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGTKSHPPDKWAHGAAAKGYLGAVKPLGGGAGAPGKGSEKGPPNGMTPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEAAEGEARSPSHKKRAAEERHPQGDRTFKKAAGASEEKKAEVPCKRREEEALVSGDAQPQDLGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARSSHPPAHHHHHHHHHHHHHTVGLNLSHARKRCLSETHGEREPCKKRLTARSISTPTCLGGSPVSEHPANVSPTAASLPQPEVILLDSDLDEPIDLRCVKMRSDAGEPPSTLQVKPEAPAVAAVVAPAPASEKPPAEAQEEPVEPLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationLVKWRGWSPKYNTWE
EEEECCCCCCCCCCC		17.84-
39PhosphorylationWRGWSPKYNTWEPEE
ECCCCCCCCCCCCHH		22.62-
41PhosphorylationGWSPKYNTWEPEENI
CCCCCCCCCCCHHHC		28.28-
90PhosphorylationVPTFARRSNVLTGLQ
CCCCHHHCCCCHHCC		26.2422817900
149AcetylationPPPGKSGKYYYQLNS
CCCCCCCCEEEEECC		36.85-
182PhosphorylationGGHKEAPSPTCPDLG
CCCCCCCCCCCCCCC		39.6323527152
184PhosphorylationHKEAPSPTCPDLGTK
CCCCCCCCCCCCCCC		40.7925619855
190PhosphorylationPTCPDLGTKSHPPDK
CCCCCCCCCCCCCCH		36.3525619855
223AcetylationGGAGAPGKGSEKGPP
CCCCCCCCCCCCCCC		59.207629095
249AcetylationTGNGIGGKMKIVKNK
CCCCCCCCEEEEECC		31.637629105
281PhosphorylationMQAVKIKSGEAAEGE
EEEEEEECCCCCCCC		45.3925159016
291PhosphorylationAAEGEARSPSHKKRA
CCCCCCCCHHHHHHH		37.4926824392
293PhosphorylationEGEARSPSHKKRAAE
CCCCCCHHHHHHHHH		49.5425159016
350PhosphorylationDLGSRKLSPTKEAFG
CCCCCCCCCCCHHHC		33.2921659605
352PhosphorylationGSRKLSPTKEAFGEQ
CCCCCCCCCHHHCCC		37.8321659605
364PhosphorylationGEQPLQLTTKPDLLA
CCCCCCCCCCCCCEE		21.5827600695
410PhosphorylationHARKRCLSETHGERE
HHHHHHHHHCCCCCC		44.0425159016
412PhosphorylationRKRCLSETHGEREPC
HHHHHHHCCCCCCCC		31.6325159016
424PhosphorylationEPCKKRLTARSISTP
CCCHHHHCCCCCCCC		24.8623140645
427PhosphorylationKKRLTARSISTPTCL
HHHHCCCCCCCCCCC		20.5823649490
429PhosphorylationRLTARSISTPTCLGG
HHCCCCCCCCCCCCC		29.5823649490
430PhosphorylationLTARSISTPTCLGGS
HCCCCCCCCCCCCCC		22.4321743459
432PhosphorylationARSISTPTCLGGSPV
CCCCCCCCCCCCCCC		22.0521743459
437PhosphorylationTPTCLGGSPVSEHPA
CCCCCCCCCCCCCCC		21.9621743459
440PhosphorylationCLGGSPVSEHPANVS
CCCCCCCCCCCCCCC		33.3021743459
447PhosphorylationSEHPANVSPTAASLP
CCCCCCCCCCCCCCC		19.1523649490
449PhosphorylationHPANVSPTAASLPQP
CCCCCCCCCCCCCCC		27.6121743459
452PhosphorylationNVSPTAASLPQPEVI
CCCCCCCCCCCCEEE		37.8123649490
463PhosphorylationPEVILLDSDLDEPID
CEEEEECCCCCCCCE		39.7921743459
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
410SPhosphorylationKinaseAKT1P31750
GPS
429SPhosphorylationKinaseAKT1P31750
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CBX4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CBX4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CIRBP_HUMANCIRBPphysical
26496610
PHC2_HUMANPHC2physical
26496610
I5P2_HUMANINPP5Bphysical
26496610
TNPO1_HUMANTNPO1physical
26496610
C1TC_HUMANMTHFD1physical
26496610
RING1_HUMANRING1physical
26496610
DNJB6_HUMANDNAJB6physical
26496610
HOIL1_HUMANRBCK1physical
26496610
PLPHP_HUMANPROSCphysical
26496610
SCAF8_HUMANSCAF8physical
26496610
MORC2_HUMANMORC2physical
26496610
CP131_HUMANCEP131physical
26496610
PHLB1_HUMANPHLDB1physical
26496610
SDF2L_HUMANSDF2L1physical
26496610
ANR11_HUMANANKRD11physical
26496610
CBX8_HUMANCBX8physical
26496610
PHC3_HUMANPHC3physical
26496610
ATD3B_HUMANATAD3Bphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CBX4_MOUSE

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Related Literatures of Post-Translational Modification

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