TIAR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIAR_MOUSE
• UniProt AC: P70318
• Protein Name: Nucleolysin TIAR
• Gene Name: Tial1
• Organism: Mus musculus (Mouse).
• Sequence Length: 392
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasmic granule . The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granu
• Protein Description: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity)..
• Protein Sequence: MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQETNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASFPTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EDDGQPRTLYVGNLS CCCCCCCEEEECCCC	29.17	28576409
12	Phosphorylation	DGQPRTLYVGNLSRD CCCCCEEEECCCCCC	13.00	28576409
30	Phosphorylation	VLILQLFSQIGPCKS HHHHHHHHHHCCCCC	29.49	21454597
102	Phosphorylation	VKVNWATTPSSQKKD EEEEEECCCCCCCCC	17.27	25338131
122	Phosphorylation	HVFVGDLSPEITTED EEEEECCCCCCCHHH	25.81	25338131
139	Acetylation	SAFAPFGKISDARVV HHCCCCCCCCCCEEE	39.14	-
139	Ubiquitination	SAFAPFGKISDARVV HHCCCCCCCCCCEEE	39.14	22790023
147	Acetylation	ISDARVVKDMATGKS CCCCEEEEECCCCCC	38.64	7720395
154	Phosphorylation	KDMATGKSKGYGFVS EECCCCCCCCCCEEE	32.43	20139300
217	Phosphorylation	FEDVVNQSSPKNCTV HHHHHHCCCCCCCEE	43.32	20415495
218	Phosphorylation	EDVVNQSSPKNCTVY HHHHHCCCCCCCEEE	30.08	20415495
243	Phosphorylation	QLMRQTFSPFGQIME HHHHHHCCCCCCEEE	23.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIAR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIAR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIAR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.