dbPTM

IF2B3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IF2B3_MOUSE
UniProt AC	Q9CPN8
Protein Name	Insulin-like growth factor 2 mRNA-binding protein 3
Gene Name	Igf2bp3
Organism	Mus musculus (Mouse).
Sequence Length	579
Subcellular Localization	Nucleus . Cytoplasm. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece a
Protein Description	RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs..
Protein Sequence	MNKLYIGNLSDHAGPADLESVFKDAKIPVAGPFLVKTGYAFVDCPDEGWALKAIEALSGKMELHGKPMEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDETAAQQNPSPQLRGRRGPGQRGSSRQASPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGSVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSTLTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQSLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KLYIGNLSDHAGPAD CEEECCCCCCCCCCC	31.20	-
73	Phosphorylation	KPMEVEHSVPKRQRI CCCEECCCCCHHHHH	26.98	-
158	Phosphorylation	VAYIPDETAAQQNPS EEECCCHHHHHHCCC	34.37	25619855
165	Phosphorylation	TAAQQNPSPQLRGRR HHHHHCCCCCCCCCC	32.59	27087446
179	Phosphorylation	RGPGQRGSSRQASPG CCCCCCCCCCCCCCC	25.24	25266776
180	Phosphorylation	GPGQRGSSRQASPGS CCCCCCCCCCCCCCC	31.10	27087446
184	Phosphorylation	RGSSRQASPGSVSKQ CCCCCCCCCCCCCCC	22.81	27087446
187	Phosphorylation	SRQASPGSVSKQKPC CCCCCCCCCCCCCCC	26.97	24453211
213	Ubiquitination	FVGAIIGKEGATIRN HHHHHHCCCCCCHHH	42.43	-
223	Ubiquitination	ATIRNITKQTQSKID CCHHHHHHHHHCCEE	47.77	-
272	Ubiquitination	HKEAQDIKFTEEIPL HHHHHCCCCCCCCCC	55.30	-
438	Phosphorylation	LSRFAGASIKIAPAE HHHHCCCCEEEECCC	24.40	25338131
450	Ubiquitination	PAEAPDAKVRMVIIT CCCCCCCEEEEEEEE	37.44	-
481	Phosphorylation	IKEENFVSPKEEVKL ECHHCCCCCHHHEEE	26.56	26060331
515	Phosphorylation	KTVNELQSLSSAEVV CCHHHHHHCCCCEEE	42.73	25338131
517	Phosphorylation	VNELQSLSSAEVVVP HHHHHHCCCCEEEEC	32.52	25338131
518	Phosphorylation	NELQSLSSAEVVVPR HHHHHCCCCEEEECC	33.47	25338131
528	Phosphorylation	VVVPRDQTPDENDQV EEECCCCCCCCCCCE	36.68	26824392
558	Phosphorylation	RKIQEILTQVKQHQQ HHHHHHHHHHHHHHH	36.66	26824392
567	Ubiquitination	VKQHQQQKALQSGPP HHHHHHHHHHHCCCC	46.88	-
576	Phosphorylation	LQSGPPQSRRK---- HHCCCCCCCCC----	39.57	20495213

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IF2B3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IF2B3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IF2B3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IF2B3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IF2B3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.	15345747 [Abstract]