STRBP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STRBP_MOUSE
• UniProt AC: Q91WM1
• Protein Name: Spermatid perinuclear RNA-binding protein
• Gene Name: Strbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 672
• Subcellular Localization: Isoform 2: Cytoplasm, cytoskeleton. Microtubule-associated that localizes to the manchette in developing spermatids.
• Protein Description: Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA..
• Protein Sequence: MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWLDETNKGTKPEGETEVKKDEAVENYSKDQGGRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCINEASIIIRNTKEPTLTLKVILTSPLIRDELEKKDGENVMMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCERDPTDALSYMTTQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSKPFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRKILDSKAIDLMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQAMGYPTGFDADIECISSDEKSDNESKNDTVSSNSSNNTGNSTTETSSTLEVRTQGPILTASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASAALAALEKLFSGPNAANNKKKKIIPQAKGVVNTAVSAAVQAVRGRGRGTLTRGAFVGATAAPGYIAPGYGTPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
343	Phosphorylation	PFQKYSWSVTDKEGA CCCCCEEEECCCCCC	14.81	28059163
345	Phosphorylation	QKYSWSVTDKEGAGS CCCEEEECCCCCCCC	35.52	28059163
453	Phosphorylation	KVLQAMGYPTGFDAD HHHHHCCCCCCCCCE	5.64	21149613
455	Phosphorylation	LQAMGYPTGFDADIE HHHCCCCCCCCCEEE	41.83	29899451
465	Phosphorylation	DADIECISSDEKSDN CCEEEEECCCCCCCC	43.31	30352176
466	Phosphorylation	ADIECISSDEKSDNE CEEEEECCCCCCCCC	29.85	21149613
470	Phosphorylation	CISSDEKSDNESKND EECCCCCCCCCCCCC	43.55	27087446
474	Phosphorylation	DEKSDNESKNDTVSS CCCCCCCCCCCCCCC	42.91	25293948
612	Asymmetric dimethylarginine	QAVRGRGRGTLTRGA HHHHCCCCCCCCCCC	33.30	-
612	Methylation	QAVRGRGRGTLTRGA HHHHCCCCCCCCCCC	33.30	24129315
617	Asymmetric dimethylarginine	RGRGTLTRGAFVGAT CCCCCCCCCCEECCC	37.24	-
617	Methylation	RGRGTLTRGAFVGAT CCCCCCCCCCEECCC	37.24	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STRBP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STRBP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STRBP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STRBP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.