CNDG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNDG2_MOUSE
• UniProt AC: Q6DFV1
• Protein Name: Condensin-2 complex subunit G2
• Gene Name: Ncapg2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1138
• Subcellular Localization: Nucleus.
• Protein Description: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst..
• Protein Sequence: MEKREAFIQAVSKELVEEFLQFLQLDKDSSNPFSLSELLDELSRKQKEELWQRLKDLLTETLLESPVDRWQTVEVEGADDMESEHSPKMRKSIKIICAIVTVILASVSIINEHENYGALLECAVILNGILYALPESEQKLQNSIQDLCVKWWERGLPAKEDMGKTAFIMLLRRSLETKSGADVCRLWRIHQALYCFDYDWEESREIKDMLLECFINVNYIKKEEGRRFLSFLFSWNVDFIKMIHETIKNQLAGLQKSLMVHIAEIYFRAWKKASGKMLETIEYDCIQDFMFHGIHLLRRSPVHSKVREVLSYFHQQKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPNFTATEMDNEIQKQFEELYNLIEDPYPRVRSTGILGVCKISSKYWEMMPPNILVDFLKKVTGELAFDISSADVRCSVFKCLPIILDNKLSHPLLEQLLPTLRYSLHDNSEKVRVAFVDLLLKIKAVRAAKFWKICPMEDILVRLEMDSRPVSRRLVSLIFNSFLPVNQPEEVWCERCVTLIQMNRAAARRFYQYAHEHTASTNIAKLIHVIRHCLNACIQRTLREGSEAHKECEKENASVLDKTLSVNDTASMAGLLEIIVILWKNIHRSLENNKEAKIYTINKFAAVLPEYLKVFKDERCKIPLFMLMSFLPASAVPVFSCGVISVLRNQESVTGRSYCTLLDCLCSWGQVGHVLELIVDWLPTVPPQAKSNLASKRKVEINDTCSVKPELALLYMEYLLTHPKNRECLLSVPQKKLNQLLKALEGSKAELESFLQSPSGNPLNFNKATALHAFGLYCRMSVHLQYKFCSEEKIHLSILDDTGSWLENKVLPLLEDQEEEYLKLRKDVYQQIIQTYLAVCKDVVMVGLGDPKFQMQLLQRSFGIMKTVKGFFYVSLLLGILKEIAGNTIIHKTDSDEKVTVLFDLVQEVFQKMLECIACIFRKQPEESLPLFHSVQTPLHEFITTIQSWHKDTAVHHAVLSTLIAAPVVEISHQLQKVSDIEELTSPQCLHDLPPFSRCLVGVIMKSSDVVRSFVDELKACVTSGDVEGIVCLTAVLHIILVINKGKHISAKVKEVATAVYRKLKTFMEITLEEDSLERFLYESSMRTLGEFLNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	FLQLDKDSSNPFSLS HHCCCCCCCCCCCHH	37.44	26643407
30	Phosphorylation	LQLDKDSSNPFSLSE HCCCCCCCCCCCHHH	59.67	27600695
65	Phosphorylation	LTETLLESPVDRWQT HHHHHHCCCCCCCEE	30.14	28066266
83	Phosphorylation	EGADDMESEHSPKMR ECCCCCCCCCCHHHH	33.69	28066266
86	Phosphorylation	DDMESEHSPKMRKSI CCCCCCCCHHHHHHH	23.36	28066266
450	Ubiquitination	LPIILDNKLSHPLLE HHHHHCCCCCCHHHH	51.54	-
791	Ubiquitination	LKALEGSKAELESFL HHHHHCCHHHHHHHH	57.65	-
800	Phosphorylation	ELESFLQSPSGNPLN HHHHHHCCCCCCCCC	24.15	25293948
802	Phosphorylation	ESFLQSPSGNPLNFN HHHHCCCCCCCCCCC	57.35	25293948
1114	Phosphorylation	LKTFMEITLEEDSLE HHHHHHCCCCHHHHH	18.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNDG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNDG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNDG2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF3C5_HUMAN	GTF3C5	physical	26496610
NCOR2_HUMAN	NCOR2	physical	26496610
NPA1P_HUMAN	URB1	physical	26496610
SMC4_HUMAN	SMC4	physical	26496610
SMC2_HUMAN	SMC2	physical	26496610
DLGP4_HUMAN	DLGAP4	physical	26496610
CNDD3_HUMAN	NCAPD3	physical	26496610
NECT3_HUMAN	PVRL3	physical	26496610
NPHP3_HUMAN	NPHP3	physical	26496610
CNDH2_HUMAN	NCAPH2	physical	26496610
UTP6_HUMAN	UTP6	physical	26496610
LCORL_HUMAN	LCORL	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.