PEBB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEBB_MOUSE
• UniProt AC: Q08024
• Protein Name: Core-binding factor subunit beta
• Gene Name: Cbfb
• Organism: Mus musculus (Mouse).
• Sequence Length: 187
• Subcellular Localization: Nucleus .
• Protein Description: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. [PubMed: 18258917]
• Protein Sequence: MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGGGDDLKLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RVVPDQRSKFENEEF CCCCCCHHHCCCHHH	35.74	-
28	Acetylation	LSRECEIKYTGFRDR HHHHCCCEECCCCCC	17.92	22826441
48	Glutathionylation	QTRFQNACRDGRSEI HHHHHHHCCCCCCEE	5.52	24333276
80	Phosphorylation	WQGEQRQTPSREYVD CCCCCCCCCCCCCCH	25.97	24899341
82	Phosphorylation	GEQRQTPSREYVDLE CCCCCCCCCCCCHHH	40.92	27566939
85	Phosphorylation	RQTPSREYVDLEREA CCCCCCCCCHHHHHC	9.73	29514104
150	Phosphorylation	FEEARRRTREFEDRD HHHHHHHHHHHHHHH	32.51	-
159	Phosphorylation	EFEDRDRSHREEMEA HHHHHHHHHHHHHHH	31.05	-
173	Phosphorylation	ARRQQDPSPGSNLGG HHHHCCCCCCCCCCC	50.62	27087446
176	Phosphorylation	QQDPSPGSNLGGGDD HCCCCCCCCCCCCCC	32.06	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	CK2	-	Uniprot
159	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEBB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEBB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RING2_MOUSE	Rnf2	physical	22325351
BMI1_MOUSE	Bmi1	physical	22325351
RUNX3_HUMAN	RUNX3	physical	25066130

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.