UTP15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UTP15_MOUSE
• UniProt AC: Q8C7V3
• Protein Name: U3 small nucleolar RNA-associated protein 15 homolog
• Gene Name: Utp15
• Organism: Mus musculus (Mouse).
• Sequence Length: 528
• Subcellular Localization: Nucleus, nucleolus . Found predominantly at the fibrillar center.
• Protein Description: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I..
• Protein Sequence: MAGYKPVAIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKIFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALSHQDETIVVGMTNGILSVKHRKSEAKKTSLPRRRRPAYRTFIKGKNYLKQRDDIMVSRPAKKHLEGYDKDLKSFRVSQALDRVLEPKCVIRTPEVTVSIIKELTRRGVLANALAGRDEKEVTRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQELVEKEIDYQRELLETLGMMDMLFATMTRNDSDPVPEHVPAELPEEKTESPTQPSDTDKNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGYKPVAI ------CCCCCCEEE	29.98	-
80	Acetylation	VKTFSRFKDTAYCAT CCCCHHCCCCEEEEE	53.73	22826441
190	Acetylation	GSYDHTVKIFDARTN ECCCCEEEEEECCCC	38.52	23236377
326	Phosphorylation	KSEAKKTSLPRRRRP CCHHHCCCCCCCCCH	45.30	-
499	Phosphorylation	ATMTRNDSDPVPEHV HHCCCCCCCCCCCCC	47.57	25777480
515	Phosphorylation	AELPEEKTESPTQPS CCCCCCCCCCCCCCC	45.00	27087446
517	Phosphorylation	LPEEKTESPTQPSDT CCCCCCCCCCCCCCC	38.18	25521595
519	Phosphorylation	EEKTESPTQPSDTDK CCCCCCCCCCCCCCC	63.49	27087446
522	Phosphorylation	TESPTQPSDTDKNS- CCCCCCCCCCCCCC-	43.24	27087446
524	Phosphorylation	SPTQPSDTDKNS--- CCCCCCCCCCCC---	53.89	25159016
528	Phosphorylation	PSDTDKNS------- CCCCCCCC-------	47.54	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UTP15_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UTP15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UTP15_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UTP15_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.