| UniProt ID | KAISO_MOUSE | |
|---|---|---|
| UniProt AC | Q8BN78 | |
| Protein Name | Transcriptional regulator Kaiso | |
| Gene Name | Zbtb33 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 671 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (By similarity).. | |
| Protein Sequence | MESRKLISATDIQYSASLLNSLNEQRGHGLFCDVTVIVEDRKFRAHRNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKVVRVRADLLDELIKSGQLLGVKFIAELGVPLSQVKSISGTEQDGTAETLPSSSSDKSLDMEKSKDEAQDNGATVMPIITESFSLSAEDNEMKKIIVTDSDDDDDDDVIFCSEILPAKEDLPSNNTATQVQPNPASVAISEVTPCASNNSPPVTNITPTQLPTPVNQATLSQTQGSEELLVSSASTHLTPNIILLNQAPLTAPPSASSSLPNHMSSSVNVLVQNQQTPNSAVLTGNKAEEEEEIIDDDDDIISSSPDSAVSNTSLVPQADNSKSTTLDGSLTQKMQIPVLPQEPPSNSLKISDVITRNTNDPGLRSKHVMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDGGEAKLDNELPKTSGSEPPNKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYQCRYCDKVFPLAEYRTKHEIHHTGERRYQCLTCGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCKSLQIRQYAYLSNKSSAMPVMKDDAVGYKVDAGKEPPVGTTSTPPQNKSTFWEDIFIQQENDSIFKQNVTDGSTEFEFIIPESY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MESRKLISATDIQYS CCCCCEEEHHHHHHH | 35.24 | - | |
| 141 | Phosphorylation | TAETLPSSSSDKSLD CCCCCCCCCCCCCCC | 31.74 | 28285833 | |
| 186 | Phosphorylation | EMKKIIVTDSDDDDD CCCEEEECCCCCCCC | 21.27 | 29550500 | |
| 188 | Phosphorylation | KKIIVTDSDDDDDDD CEEEECCCCCCCCCC | 33.31 | 27087446 | |
| 251 | Phosphorylation | ITPTQLPTPVNQATL CCCCCCCCCCCCEEC | 48.76 | - | |
| 491 | Nitration | LIVDGRVYYICIVCK EEECCEEEEEEEEEC | 5.93 | - | |
| 492 | Nitration | IVDGRVYYICIVCKR EECCEEEEEEEEECC | 6.10 | - | |
| 603 | Phosphorylation | AYLSNKSSAMPVMKD HHHCCCCCCCCEECC | 30.14 | 25195567 | |
| 627 | Phosphorylation | GKEPPVGTTSTPPQN CCCCCCCCCCCCCCC | 20.15 | 25338131 | |
| 629 | Phosphorylation | EPPVGTTSTPPQNKS CCCCCCCCCCCCCCC | 38.46 | 28285833 | |
| 630 | Phosphorylation | PPVGTTSTPPQNKST CCCCCCCCCCCCCCC | 36.57 | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KAISO_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KAISO_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KAISO_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KAISO_MOUSE | Zbtb33 | physical | 20211142 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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