SP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP2_MOUSE
• UniProt AC: Q9D2H6
• Protein Name: Transcription factor Sp2
• Gene Name: Sp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 612
• Subcellular Localization: Nucleus.
• Protein Description: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites..
• Protein Sequence: MSDPQMSMAATAAVSPSDYLQPAAATTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPCKNSFSILSSKGNILQIQGSQLSTSYPGGQFVFAIQNPTLINKGSRSNASIQYQVPQIQGNSSQTIQVQPSLTNQIQVIPGTNQAITTPSTSGHKPVPIKPAPVQKSSTTTTPVQSGANVVKLTGGGSNMTLTLPLNNLVNTSDIGGPAQLLTESPPTPLSKTNKKARKKSLPVSQPSVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPTPTQVYIRTPSGEVQTVLVQDSPPATAATTSTVTCNSPALRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGEAQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLGTKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PQMSMAATAAVSPSD HHHHHHHEECCCHHH	12.95	26643407
15	Phosphorylation	MAATAAVSPSDYLQP HHHEECCCHHHHCCC	17.60	26643407
17	Phosphorylation	ATAAVSPSDYLQPAA HEECCCHHHHCCCCC	31.23	26643407
19	Phosphorylation	AAVSPSDYLQPAAAT ECCCHHHHCCCCCCC	16.15	26643407
26	Phosphorylation	YLQPAAATTQDSQPS HCCCCCCCCCCCCCC	21.91	26643407
27	Phosphorylation	LQPAAATTQDSQPSP CCCCCCCCCCCCCCH	26.17	26643407
33	Phosphorylation	TTQDSQPSPLALLAA CCCCCCCCHHHHHHH	25.55	25338131
55	Phosphorylation	PAVEAAVTPPAPPQP CCEEECCCCCCCCCC	20.87	27180971
78	Phosphorylation	KPAPLPLSPCKNSFS CCCCCCCCCCCCCEE	26.72	26824392
186	O-linked_Glycosylation	KPAPVQKSSTTTTPV CCCCCCCCCCCCCCC	18.80	51588475
370	Phosphorylation	QTVLVQDSPPATAAT EEEEEECCCCCCCCE	18.72	27149854
394	Phosphorylation	ALRAPHLSGTSKKHS HHCCCCCCCCCCCHH	36.67	27149854
521	Acetylation	KRSGEQGKKKHVCHI CCCCCCCCCEEEEEC	59.34	7613481
522	Acetylation	RSGEQGKKKHVCHIP CCCCCCCCEEEEECC	55.74	7613493
549	Phosphorylation	RAHVRLHTGERPFVC HHEEEECCCCCCEEE	45.38	-
568	Phosphorylation	CGKRFTRSDELQRHA ECCCCCCCHHHHHHH	32.17	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP2_MOUSE	Sp2	physical	20211142
TF2AA_MOUSE	Gtf2a1	physical	20211142
GMEB2_MOUSE	Gmeb2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.