BC11B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BC11B_MOUSE
• UniProt AC: Q99PV8
• Protein Name: B-cell lymphoma/leukemia 11B
• Gene Name: Bcl11b
• Organism: Mus musculus (Mouse).
• Sequence Length: 884
• Subcellular Localization: Nucleus .
• Protein Description: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. [PubMed: 12717433 Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes]
• Protein Sequence: MSRRKQGNPQHLSQRELITPEADHVEATILEEDEGLEIEEPSSLGLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKKKQCGGLGPCYDKVLDKSSPPPSSRSELRRVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPSMAPIAASSSHPPTSVITSPLRALGVLPPCFPLPCCGARPISGDGTQGEGQMEAPFGCQCELSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASTSLTPRLTIPPPLGPETVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPAGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELPGDLKAADGDFRHHESDPSLGPEPEDDEDEEEEEEELLLENESRPESSFSMDSELGRGRENGGGVPPGVAGAGAAAAALADEKALALGKVMEDAGLGALPQYGEKRGAFLKRAGDTGDAGAVGCGDAGAPGAVNGRGGAFAPGAEPFPALFPRKPAPLPSPGLGGPALHAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	QGNPQHLSQRELITP CCCHHHCCHHCCCCC	25.68	-
95	Phosphorylation	YDKVLDKSSPPPSSR HHHHHCCCCCCCCCH	47.98	28833060
96	Phosphorylation	DKVLDKSSPPPSSRS HHHHCCCCCCCCCHH	47.36	25177544
100	Phosphorylation	DKSSPPPSSRSELRR CCCCCCCCCHHHHHC	44.12	22871156
101	Phosphorylation	KSSPPPSSRSELRRV CCCCCCCCHHHHHCC	45.67	28833060
103	Phosphorylation	SPPPSSRSELRRVSE CCCCCCHHHHHCCCC	42.82	25168779
109	Phosphorylation	RSELRRVSEPVEIGI HHHHHCCCCCEEEEE	34.08	28833060
119	Phosphorylation	VEIGIQVTPDEDDHL EEEEEEECCCCCCCC	14.51	28833060
128 (in isoform 2)	Phosphorylation	-	36.56	27566939
128	Phosphorylation	DEDDHLLSPTKGICP CCCCCCCCCCCCCCC	36.56	28833060
130	Phosphorylation	DDHLLSPTKGICPKQ CCCCCCCCCCCCCCC	38.23	28833060
151	Phosphorylation	CRPAQLPSMAPIAAS CCHHHCCCCCCCCCC	35.85	22817900
158	Phosphorylation	SMAPIAASSSHPPTS CCCCCCCCCCCCCCC	24.29	21082442
160	Phosphorylation	APIAASSSHPPTSVI CCCCCCCCCCCCCEE	37.20	21183079
169	Phosphorylation	PPTSVITSPLRALGV CCCCEECCHHHHCCC	15.71	-
256	Phosphorylation	YLEPGPASTSLTPRL EEECCCCCCCCCCCE	22.97	28833060
257	Phosphorylation	LEPGPASTSLTPRLT EECCCCCCCCCCCEE	29.84	28833060
258	Phosphorylation	EPGPASTSLTPRLTI ECCCCCCCCCCCEEC	27.96	28833060
260	Phosphorylation	GPASTSLTPRLTIPP CCCCCCCCCCEECCC	13.21	28833060
277	Phosphorylation	GPETVAQSPLMNFLG CHHHHHCCCCHHHHC	15.40	27600695
293	Methylation	SNPFNLLRMTGPILR CCHHHHHHCCCCCCC	24.63	24129315
313	Phosphorylation	GEGRLPGTPPLFSPP CCCCCCCCCCCCCCC	21.57	28833060
318	Phosphorylation	PGTPPLFSPPPRHHL CCCCCCCCCCCCCCC	44.15	28833060
322	Asymmetric dimethylarginine	PLFSPPPRHHLDPHR CCCCCCCCCCCCHHH	35.31	-
322	Methylation	PLFSPPPRHHLDPHR CCCCCCCCCCCCHHH	35.31	24129315
358	Phosphorylation	LNPMAIDSPAMDFSR HCCCCCCCCCHHHHH	14.40	27600695
374	Phosphorylation	LRELAGNSSTPPPVS HHHHHCCCCCCCCCC	34.37	28833060
375	Phosphorylation	RELAGNSSTPPPVSP HHHHCCCCCCCCCCC	49.27	28833060
376	Phosphorylation	ELAGNSSTPPPVSPG HHHCCCCCCCCCCCC	39.37	25521595
381	Phosphorylation	SSTPPPVSPGRGNPM CCCCCCCCCCCCCHH	27.66	25521595
398	Phosphorylation	LLNPFQPSPKSPFLS HCCCCCCCCCCCCCC	33.89	22817900
401	Phosphorylation	PFQPSPKSPFLSTPP CCCCCCCCCCCCCCC	25.03	28833060
405	Phosphorylation	SPKSPFLSTPPLPPM CCCCCCCCCCCCCCC	38.97	28833060
406	Phosphorylation	PKSPFLSTPPLPPMP CCCCCCCCCCCCCCC	30.95	28833060
416	Phosphorylation	LPPMPAGTPPPQPPA CCCCCCCCCCCCCCC	34.43	28833060
449	Phosphorylation	IVHRRSHTGEKPYKC EEECCCCCCCCCCCC	48.56	25266776
482	Phosphorylation	THMHKAGSLAGRSDD HHHHHHHCCCCCCCC	21.65	22324799
487	Phosphorylation	AGSLAGRSDDGLSAA HHCCCCCCCCCCCCC	38.85	28833060
492	Phosphorylation	GRSDDGLSAASSPEP CCCCCCCCCCCCCCC	27.58	28833060
495	Phosphorylation	DDGLSAASSPEPGTS CCCCCCCCCCCCCCC	46.25	28833060
496	Phosphorylation	DGLSAASSPEPGTSE CCCCCCCCCCCCCCC	28.67	21082442
501	Phosphorylation	ASSPEPGTSELPGDL CCCCCCCCCCCCCCC	29.73	28833060
502	Phosphorylation	SSPEPGTSELPGDLK CCCCCCCCCCCCCCC	42.95	28833060
520	Phosphorylation	GDFRHHESDPSLGPE CCCCCCCCCCCCCCC	50.92	21082442
523	Phosphorylation	RHHESDPSLGPEPED CCCCCCCCCCCCCCC	51.45	21082442
552	Phosphorylation	NESRPESSFSMDSEL CCCCCCCCCCCCCCC	21.48	-
554	Phosphorylation	SRPESSFSMDSELGR CCCCCCCCCCCCCCC	24.51	-
557	Phosphorylation	ESSFSMDSELGRGRE CCCCCCCCCCCCCCC	26.53	-
664	Phosphorylation	RKPAPLPSPGLGGPA CCCCCCCCCCCCHHH	39.00	28833060
679	Sumoylation	LHAAKRIKVEKDLEL HHHHHCCCCCCCCCC	48.66	-
679	Sumoylation	LHAAKRIKVEKDLEL HHHHHCCCCCCCCCC	48.66	-
725	Phosphorylation	GFTDARQSPFATSSE CCCCCCCCCCCCCCC	19.21	21183079
731	Phosphorylation	QSPFATSSEHSSENG CCCCCCCCCCCCCCC	34.67	-
734	Phosphorylation	FATSSEHSSENGSLR CCCCCCCCCCCCCEE	34.98	-
743	Phosphorylation	ENGSLRFSTPPGDLL CCCCEEECCCCCCCC	33.30	28833060
744	Phosphorylation	NGSLRFSTPPGDLLD CCCEEECCCCCCCCC	30.69	22942356
755	Phosphorylation	DLLDGGLSGRSGTAS CCCCCCCCCCCCCCC	35.12	-
760	Phosphorylation	GLSGRSGTASGGSTP CCCCCCCCCCCCCCC	20.92	27600695
762	Phosphorylation	SGRSGTASGGSTPHL CCCCCCCCCCCCCCC	43.45	25266776
765	Phosphorylation	SGTASGGSTPHLGGP CCCCCCCCCCCCCCC	42.14	21183079
766	Phosphorylation	GTASGGSTPHLGGPG CCCCCCCCCCCCCCC	20.29	19060867
778	Phosphorylation	GPGPGRPSSKEGRRS CCCCCCCCCCCCCCC	53.32	25266776
779	Phosphorylation	PGPGRPSSKEGRRSD CCCCCCCCCCCCCCC	37.09	25266776
785	Phosphorylation	SSKEGRRSDTCEYCG CCCCCCCCCCCHHHH	35.59	27600695
841	Acetylation	KTHGQIGKEVYRCDI HHHCCCCCEEEECCC	45.71	-
864	Acetylation	STLEKHMKKWHGEHL HHHHHHHHHHCCHHH	53.05	7719143
877	Acetylation	HLLTNDVKIEQAERS HHCCCCCCHHHHHCC	43.31	7719153
877	Sumoylation	HLLTNDVKIEQAERS HHCCCCCCHHHHHCC	43.31	-
877	Sumoylation	HLLTNDVKIEQAERS HHCCCCCCHHHHHCC	43.31	-
884	Phosphorylation	KIEQAERS------- CHHHHHCC-------	35.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BC11B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BC11B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BC11B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EP300_MOUSE	Ep300	physical	16809611

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.