PUR8_MOUSE - dbPTM
PUR8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUR8_MOUSE
UniProt AC P54822
Protein Name Adenylosuccinate lyase
Gene Name Adsl
Organism Mus musculus (Mouse).
Sequence Length 484
Subcellular Localization
Protein Description Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate..
Protein Sequence MAASGDPGSAESYRSPLAARYASREMCFLFSDRYKFQTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLNNIDFQMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAFDLLLPKLARVISRLADFAKDRADLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDELRFRGVKGTTGTQASFLQLFEGDHQKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMALTMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEHLLDPSSFTGRAPQQVHRFLEEEVRPLLKPYGNEMAVKAELCL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAASGDPGS
------CCCCCCCCC		15.44-
4Phosphorylation----MAASGDPGSAE
----CCCCCCCCCHH		33.9025293948
9PhosphorylationAASGDPGSAESYRSP
CCCCCCCCHHHHCCH		33.9626745281
12PhosphorylationGDPGSAESYRSPLAA
CCCCCHHHHCCHHHH		26.0926745281
13PhosphorylationDPGSAESYRSPLAAR
CCCCHHHHCCHHHHH		13.4526745281
15PhosphorylationGSAESYRSPLAARYA
CCHHHHCCHHHHHHH		18.9425266776
27S-nitrosocysteineRYASREMCFLFSDRY
HHHCHHHHHHCCCHH		1.99-
27GlutathionylationRYASREMCFLFSDRY
HHHCHHHHHHCCCHH		1.9924333276
27S-nitrosylationRYASREMCFLFSDRY
HHHCHHHHHHCCCHH		1.9921278135
35MalonylationFLFSDRYKFQTWRQL
HHCCCHHHHHHHHHH		31.7126320211
82AcetylationQMAAEEEKRLRHDVM
HHHHHHHHHHHHHHH		61.0723236377
98GlutathionylationHVHTFGHCCPKAAGI
HHHHCCCCCCCCCCE		4.3224333276
99GlutathionylationVHTFGHCCPKAAGII
HHHCCCCCCCCCCEE		3.0024333276
111PhosphorylationGIIHLGATSCYVGDN
CEEEECCCEEECCCC		19.9623984901
112PhosphorylationIIHLGATSCYVGDNT
EEEECCCEEECCCCC		11.6923984901
114PhosphorylationHLGATSCYVGDNTDL
EECCCEEECCCCCCE		13.7723984901
134AcetylationAFDLLLPKLARVISR
HHHHHHHHHHHHHHH		55.5422826441
147MalonylationSRLADFAKDRADLPT
HHHHHHHHHHCCCCC		47.9826320211
147AcetylationSRLADFAKDRADLPT
HHHHHHHHHHCCCCC		47.9822826441
199UbiquitinationELRFRGVKGTTGTQA
HHHHCCCCCCCCCHH		54.0522790023
201PhosphorylationRFRGVKGTTGTQASF
HHCCCCCCCCCHHHH		19.1428464351
207PhosphorylationGTTGTQASFLQLFEG
CCCCCHHHHHHHHHC		19.3728464351
218UbiquitinationLFEGDHQKVEQLDKM
HHHCCHHHHHHHHHH		44.3022790023
261PhosphorylationVLASLGASVHKICTD
HHHHCCCHHHHHHHH		23.9724759943
266S-nitrosocysteineGASVHKICTDIRLLA
CCHHHHHHHHHHHHH		3.14-
266S-nitrosylationGASVHKICTDIRLLA
CCHHHHHHHHHHHHH		3.1421278135
267PhosphorylationASVHKICTDIRLLAN
CHHHHHHHHHHHHHH		37.6224759943
284AcetylationEMEEPFEKQQIGSSA
HCCCCHHHCCCCCCC		48.1323236377
289PhosphorylationFEKQQIGSSAMPYKR
HHHCCCCCCCCCCCC		19.2929514104
295AcetylationGSSAMPYKRNPMRSE
CCCCCCCCCCCCHHH		39.5722733758
359PhosphorylationLNTLQNISEGLVVYP
HHHHHHHCCCCCCCH		32.9128576409
365PhosphorylationISEGLVVYPKVIERR
HCCCCCCCHHHHHHH		7.0028576409
382PhosphorylationQELPFMATENIIMAM
HHCCCCCHHHHHHHH		20.1352836395
415AcetylationQQAAAVVKQEGGDND
HHHHHHHHHHCCCCH		35.7123236377
432PhosphorylationERIRADAYFSPIHSQ
HHHHHHHHCCCHHHH		12.7251458553
434PhosphorylationIRADAYFSPIHSQLE
HHHHHHCCCHHHHHH		15.4025293948
438PhosphorylationAYFSPIHSQLEHLLD
HHCCCHHHHHHHHCC		36.8619060867
470AcetylationEEVRPLLKPYGNEMA
HHHHHHHCCCCCCCC		43.8223954790
470UbiquitinationEEVRPLLKPYGNEMA
HHHHHHHCCCCCCCC		43.8222790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUR8_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUR8_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUR8_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PUR8_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUR8_MOUSE

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Related Literatures of Post-Translational Modification

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