| UniProt ID | NOSIP_MOUSE | |
|---|---|---|
| UniProt AC | Q9D6T0 | |
| Protein Name | Nitric oxide synthase-interacting protein | |
| Gene Name | Nosip | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 301 | |
| Subcellular Localization | Cytoplasm . Nucleus . Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. | |
| Protein Description | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. [PubMed: 25546391 Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity] | |
| Protein Sequence | MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQVKAYEKQRGARREEQKELQRAAAQDQVRGFLEKEAAIVSRPLNPFMPKAATLPNTEGEQPGPSVGPVGKDKDKALPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVLQRGGTGFAGSGVKLQAEMSRPVMQA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | NCTAGAVYTYHEKKK CCCCCCEEEEECCCC | 10.88 | - | |
| 16 | Phosphorylation | TAGAVYTYHEKKKDT CCCCEEEEECCCCCC | 7.12 | - | |
| 28 | Phosphorylation | KDTAASGYGTQNIRL CCCCCCCCCCCCEEE | 17.95 | 26060331 | |
| 30 | Phosphorylation | TAASGYGTQNIRLSR CCCCCCCCCCEEECC | 15.23 | 26060331 | |
| 36 | Phosphorylation | GTQNIRLSRDAVKDF CCCCEEECCHHHCCC | 20.47 | 25266776 | |
| 78 | Ubiquitination | LEYILHQKREIARQV HHHHHHHHHHHHHHH | 41.05 | 22790023 | |
| 153 | Ubiquitination | PSVGPVGKDKDKALP CCCCCCCCCCCCCCC | 62.94 | 22790023 | |
| 157 | Ubiquitination | PVGKDKDKALPSFWI CCCCCCCCCCCCCCC | 58.52 | 22790023 | |
| 166 | Phosphorylation | LPSFWIPSLTPEAKA CCCCCCCCCCHHHHC | 35.42 | 26643407 | |
| 168 | Phosphorylation | SFWIPSLTPEAKATK CCCCCCCCHHHHCCC | 24.34 | 26745281 | |
| 172 | Ubiquitination | PSLTPEAKATKLEKP CCCCHHHHCCCCCCC | 55.73 | 22790023 | |
| 183 (in isoform 2) | Phosphorylation | - | 5.15 | 30635358 | |
| 190 | Ubiquitination | VTCPMSGKPLRMSDL EECCCCCCCCCHHHC | 33.31 | 22790023 | |
| 289 | Ubiquitination | GFAGSGVKLQAEMSR CCCCCCCEEEEEECC | 38.11 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOSIP_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOSIP_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOSIP_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NOSIP_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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