PRP4B_MOUSE - dbPTM
PRP4B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP4B_MOUSE
UniProt AC Q61136
Protein Name Serine/threonine-protein kinase PRP4 homolog
Gene Name Prpf4b
Organism Mus musculus (Mouse).
Sequence Length 1007
Subcellular Localization Nucleus.
Protein Description Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF..
Protein Sequence MAATEPPSLREQAEMDDADNSEKSVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIEASDKEGLSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSPIVNERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKLRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNISVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAATEPPSL
------CCCCCCCCH		34.10-
4Phosphorylation----MAATEPPSLRE
----CCCCCCCCHHH		56.9625619855
8PhosphorylationMAATEPPSLREQAEM
CCCCCCCCHHHHHHH		51.2626824392
21PhosphorylationEMDDADNSEKSVNEE
HHCCCCCCCCCCCHH		47.1225521595
24PhosphorylationDADNSEKSVNEENGE
CCCCCCCCCCHHCCC		26.5625521595
33PhosphorylationNEENGEVSEDQSQNK
CHHCCCCCHHHHHCH		31.0225521595
37PhosphorylationGEVSEDQSQNKHSRH
CCCCHHHHHCHHHHH		48.3025521595
62PhosphorylationHKKHKHSSEEDRDKK
HHHCCCCCHHHHHHH		44.7326824392
88PhosphorylationRKEVIEASDKEGLSP
HHHHHHHHHCCCCCH		36.1027087446
94PhosphorylationASDKEGLSPAKRTKL
HHHCCCCCHHHCCCH		33.4027087446
100AcetylationLSPAKRTKLDDLALL
CCHHHCCCHHHHHHH		54.6923806337
112UbiquitinationALLEDLEKQRALIKA
HHHHHHHHHHHHHHH		53.00-
132PhosphorylationLMEGKVQSGMGLILQ
HHHCCCCCCCEEHHH		33.4625619855
134OxidationEGKVQSGMGLILQGY
HCCCCCCCEEHHHCC		4.8317242355
141PhosphorylationMGLILQGYESGSEEE
CEEHHHCCCCCCCCC		8.2527087446
143PhosphorylationLILQGYESGSEEEGE
EHHHCCCCCCCCCHH		38.8518388127
145PhosphorylationLQGYESGSEEEGEIH
HHCCCCCCCCCHHHH		51.6318388127
161PhosphorylationKARNGNRSSTRSSST
HHHCCCCCCCCCCCC		39.8123737553
162PhosphorylationARNGNRSSTRSSSTR
HHCCCCCCCCCCCCC		25.3023737553
163PhosphorylationRNGNRSSTRSSSTRG
HCCCCCCCCCCCCCC		35.5023737553
165PhosphorylationGNRSSTRSSSTRGKL
CCCCCCCCCCCCCCE		28.8223737553
166PhosphorylationNRSSTRSSSTRGKLE
CCCCCCCCCCCCCEE		32.2223737553
167PhosphorylationRSSTRSSSTRGKLEI
CCCCCCCCCCCCEEE		24.3023737553
168PhosphorylationSSTRSSSTRGKLEIT
CCCCCCCCCCCEEEC		45.4423737553
171AcetylationRSSSTRGKLEITDNK
CCCCCCCCEEECCCC		39.3923806337
175PhosphorylationTRGKLEITDNKNSAK
CCCCEEECCCCCHHH		24.9325266776
180PhosphorylationEITDNKNSAKKRSKS
EECCCCCHHHHHHHH		42.9728507225
197PhosphorylationKERTRHRSDKRKSKG
HHHHHHHHHHHHHCC		41.16-
202PhosphorylationHRSDKRKSKGAGEML
HHHHHHHHCCHHHHH		40.1125367039
233PhosphorylationSPSKRSKSQDQARKS
CCCHHHHHHHHHHHC		39.9923375375
240PhosphorylationSQDQARKSKSPPLRR
HHHHHHHCCCCCHHH		32.5826824392
242PhosphorylationDQARKSKSPPLRRRS
HHHHHCCCCCHHHHH		38.5526824392
249PhosphorylationSPPLRRRSQEKVGKA
CCCHHHHHHHHHHCC		40.66-
258PhosphorylationEKVGKARSPAEEKMK
HHHHCCCCHHHHHHH		33.0625521595
278PhosphorylationKIKDRKKSPIVNERS
CCCCCCCCCCCCHHH		23.9325521595
285PhosphorylationSPIVNERSRDRSKKS
CCCCCHHHCCCCCCC		32.1425266776
289PhosphorylationNERSRDRSKKSKSPV
CHHHCCCCCCCCCCC		49.0423375375
292PhosphorylationSRDRSKKSKSPVDLR
HCCCCCCCCCCCCHH		41.9426824392
294PhosphorylationDRSKKSKSPVDLRDK
CCCCCCCCCCCHHHH		36.9326824392
302PhosphorylationPVDLRDKSKDRRSRS
CCCHHHHHHHHHHHH		44.0427841257
328PhosphorylationKEKKPIKSPSKDASS
HCCCCCCCCCCCCCC		34.8226824392
330PhosphorylationKKPIKSPSKDASSGK
CCCCCCCCCCCCCCC		50.7027818261
335PhosphorylationSPSKDASSGKENRSP
CCCCCCCCCCCCCCC		56.4523684622
341PhosphorylationSSGKENRSPSRRPGR
CCCCCCCCCCCCCCC		38.5223684622
343PhosphorylationGKENRSPSRRPGRSP
CCCCCCCCCCCCCCC		42.0123140645
349PhosphorylationPSRRPGRSPKRRSLS
CCCCCCCCCCCCCCC		40.4625195567
354PhosphorylationGRSPKRRSLSPKLRD
CCCCCCCCCCHHHHC		36.9127149854
356PhosphorylationSPKRRSLSPKLRDKS
CCCCCCCCHHHHCCH		22.6427149854
366PhosphorylationLRDKSRRSRSPLLND
HHCCHHHCCCCHHCC		35.6818388127
368PhosphorylationDKSRRSRSPLLNDRR
CCHHHCCCCHHCCHH		22.5818388127
376PhosphorylationPLLNDRRSKQSKSPS
CHHCCHHHCCCCCCC		35.6227717184
379PhosphorylationNDRRSKQSKSPSRTL
CCHHHCCCCCCCCCC		38.5529514104
381PhosphorylationRRSKQSKSPSRTLSP
HHHCCCCCCCCCCCC		33.1022324799
383PhosphorylationSKQSKSPSRTLSPGR
HCCCCCCCCCCCCCH		45.0125521595
385PhosphorylationQSKSPSRTLSPGRRA
CCCCCCCCCCCCHHH		35.6122324799
387PhosphorylationKSPSRTLSPGRRAKS
CCCCCCCCCCHHHHH		25.3725521595
394PhosphorylationSPGRRAKSRSLERKR
CCCHHHHHHHHHHHH		26.5623737553
396PhosphorylationGRRAKSRSLERKRRE
CHHHHHHHHHHHHHH		41.4923737553
410PhosphorylationEPERRRLSSPRTRPR
HHHHHHCCCCCCCCH		36.1622324799
411PhosphorylationPERRRLSSPRTRPRD
HHHHHCCCCCCCCHH		24.0027149854
414PhosphorylationRRLSSPRTRPRDDIL
HHCCCCCCCCHHHCC		48.7025777480
427PhosphorylationILGRCERSKDASPIN
CCHHCCCCCCCCCCC		16.7623527152
431PhosphorylationCERSKDASPINRWSP
CCCCCCCCCCCCCCC		36.1218388127
437PhosphorylationASPINRWSPTRRRSR
CCCCCCCCCCCCCCC		17.1025521595
439PhosphorylationPINRWSPTRRRSRSP
CCCCCCCCCCCCCCC		31.1527742792
443PhosphorylationWSPTRRRSRSPIRRR
CCCCCCCCCCCCHHH		34.9925159016
445PhosphorylationPTRRRSRSPIRRRSR
CCCCCCCCCCHHHCC		26.4025159016
451PhosphorylationRSPIRRRSRSPLRRS
CCCCHHHCCCCCCCC		34.9925159016
453PhosphorylationPIRRRSRSPLRRSRS
CCHHHCCCCCCCCCC		29.5422324799
458PhosphorylationSRSPLRRSRSPRRRS
CCCCCCCCCCCCCCC		30.5820450229
460PhosphorylationSPLRRSRSPRRRSRS
CCCCCCCCCCCCCCC		24.8120450229
465PhosphorylationSRSPRRRSRSPRRRD
CCCCCCCCCCHHHHH		34.9920450229
467PhosphorylationSPRRRSRSPRRRDRS
CCCCCCCCHHHHHHH		24.8120450229
507PhosphorylationKEDKFKGSLSEGMKV
CCCHHCCCCCCCCCC		29.3429472430
509PhosphorylationDKFKGSLSEGMKVEQ
CHHCCCCCCCCCCEE		33.5328066266
518PhosphorylationGMKVEQESSSDDNLE
CCCCEECCCCCCCHH		34.5319367708
519PhosphorylationMKVEQESSSDDNLED
CCCEECCCCCCCHHH		36.7119367708
520PhosphorylationKVEQESSSDDNLEDF
CCEECCCCCCCHHHC		59.2619367708
554PhosphorylationAIVQKYKYLAEDSNI
HHHHHHHHHHCCCCC		14.1930635358
559PhosphorylationYKYLAEDSNISVPSE
HHHHHCCCCCCCCCC		27.8030635358
562PhosphorylationLAEDSNISVPSEPSS
HHCCCCCCCCCCCCC		32.0225195567
565PhosphorylationDSNISVPSEPSSPQS
CCCCCCCCCCCCCCC		61.0421149613
568PhosphorylationISVPSEPSSPQSSTR
CCCCCCCCCCCCCCC		51.0721149613
569PhosphorylationSVPSEPSSPQSSTRS
CCCCCCCCCCCCCCC		37.3621149613
572PhosphorylationSEPSSPQSSTRSRSP
CCCCCCCCCCCCCCC		36.7421149613
573PhosphorylationEPSSPQSSTRSRSPS
CCCCCCCCCCCCCCC		23.6921149613
574PhosphorylationPSSPQSSTRSRSPSP
CCCCCCCCCCCCCCH		37.6030635358
576PhosphorylationSPQSSTRSRSPSPDD
CCCCCCCCCCCCHHH		36.8821082442
578PhosphorylationQSSTRSRSPSPDDIL
CCCCCCCCCCHHHHH		30.8625521595
580PhosphorylationSTRSRSPSPDDILER
CCCCCCCCHHHHHHH		42.0525521595
622PhosphorylationTVEQNNGSSQKKILA
EEEECCCCCCCCEEC		31.5525338131
623PhosphorylationVEQNNGSSQKKILAP
EEECCCCCCCCEECC		47.6329514104
634PhosphorylationILAPDMFTESDDMFA
EECCCCCCCCHHHHH		28.1326643407
636PhosphorylationAPDMFTESDDMFAAY
CCCCCCCCHHHHHHH		35.5326643407
656AcetylationLRAAGIGKDFKENPN
HHHCCCCCCCCCCCC		59.0623806337
717AcetylationANQEVAVKIIRNNEL
CCHHHHHHHHHCCHH		23.76-
737UbiquitinationLKELEFLKKLNDADP
HHHHHHHHHHCCCCC		61.61-
794PhosphorylationLHIKAVRSYSQQLFL
HHHHHHHHHHHHHHH		23.6520139300
795PhosphorylationHIKAVRSYSQQLFLA
HHHHHHHHHHHHHHH		10.4320139300
837PhosphorylationLKLCDFGSASHVADN
HHHCCCCCHHHCCCC		26.9624925903
839PhosphorylationLCDFGSASHVADNDI
HCCCCCHHHCCCCCC		21.8625619855
847PhosphorylationHVADNDITPYLVSRF
HCCCCCCHHHHHHHH		14.5624925903
849PhosphorylationADNDITPYLVSRFYR
CCCCCHHHHHHHHHC		15.8722322096
852PhosphorylationDITPYLVSRFYRAPE
CCHHHHHHHHHCCCE		17.6822322096
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP4B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP4B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP4B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PRP4B_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP4B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88; SER-94; SER-431;SER-437 AND TYR-849, AND MASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278; SER-292; SER-294;SER-366; SER-368; SER-576; SER-578 AND SER-580, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427; SER-431; SER-437;SER-580; TYR-849 AND SER-852, AND MASS SPECTROMETRY.
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576; SER-578 ANDSER-580, AND MASS SPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-849, AND MASSSPECTROMETRY.

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