IF4G3_MOUSE - dbPTM
IF4G3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF4G3_MOUSE
UniProt AC Q80XI3
Protein Name Eukaryotic translation initiation factor 4 gamma 3
Gene Name Eif4g3
Organism Mus musculus (Mouse).
Sequence Length 1579
Subcellular Localization
Protein Description Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 (By similarity)..
Protein Sequence MNSQPQARSPFFQRPQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQHIMMVNHLPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVPSPTSCTAASGPSLTDNSDICKKPCSVAPHDSQLISSTILINEMNGVGEKLSAKENTVGMLRQEVLPLTLELEILEHPQEELKVECTPTPIAPSMLPAFSPAPPTPPTSPPCPPVVLSAAIARSPAVATEVQRVADEGESLRTCLSKDAKEMQDKAESESDGQAEETADPQSLHSGRSPAPVQTATTAPKSWKKTKEQTRTPDEVLEAEAEPKAEEELAVDSVLEPEQEKMSQGFPSERDPSALKRGKAEEGNGEEAEPVRNGAESASEGEGGDGNSGSADSSADGLTFPFKAESWKPADTEGKKQYDREFLLDIQFMPACIQKPEGLPPISDVVLDKINQPRLSMRTLDPRILPRGPDFTPAFADFPRQTPGGRGVPLLNVGPRRSQPGQRREPRKIITVSVKEDVHLRKAENAWKPSQKRDSHADDPESIKTQELFRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASESDALRSSASSLNRFSPLQPPAPSGSPSATPLEFDSRRALTSRGSMGREKSDKPIPAGTARPNTFLRGSSKDLLDNQSQEEQRREMLETVKQLTGGLDAERASTEADRSKTRELAKSEMCAVPAPDKPALSEEEVERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELIVEFSKPLLPVGRAGVLLSEILHLLCRQMSHKKVGALWREADLSWKDFLPEGEDVHHFLLEQKLDFTESEGPCSSEALSKKELSAEELSQRLEKLIMEEKADDERIFDWVEANLDESQMSSPTFLRALMTAVCKAAIIADCSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQAGKGVALKSVTAFFTWLREAEEESEDN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MNSQPQARSP
-----CCCCCCCCCC		55.9118779572
141PhosphorylationPAKREKKTIRIRDPN
CCCCCCCCEEECCCC		26.9323375375
160PhosphorylationDITEEIMSGGGSRNP
CCHHHHHCCCCCCCC		39.6925293948
164PhosphorylationEIMSGGGSRNPTPPI
HHHCCCCCCCCCCCC		31.9619060867
168PhosphorylationGGGSRNPTPPIGRPA
CCCCCCCCCCCCCCC		45.2926824392
176PhosphorylationPPIGRPASTPTPPQQ
CCCCCCCCCCCCCHH		37.2925293948
177PhosphorylationPIGRPASTPTPPQQL
CCCCCCCCCCCCHHC		33.0325293948
179PhosphorylationGRPASTPTPPQQLPS
CCCCCCCCCCHHCCC		47.9225293948
186PhosphorylationTPPQQLPSQVPEHSP
CCCHHCCCCCCCCCC		53.0225293948
192PhosphorylationPSQVPEHSPVVYGTV
CCCCCCCCCCEEEEE		20.0925293948
196PhosphorylationPEHSPVVYGTVESAH
CCCCCCEEEEEHHHH		13.8125293948
198PhosphorylationHSPVVYGTVESAHLA
CCCCEEEEEHHHHHH		11.9225293948
201PhosphorylationVVYGTVESAHLAAST
CEEEEEHHHHHHHCC		19.3625293948
207PhosphorylationESAHLAASTPVTAAS
HHHHHHHCCCCCCCC		27.8625293948
208PhosphorylationSAHLAASTPVTAASD
HHHHHHCCCCCCCCC		19.6325293948
211PhosphorylationLAASTPVTAASDQKQ
HHHCCCCCCCCCCCC		20.0825293948
214PhosphorylationSTPVTAASDQKQEEK
CCCCCCCCCCCCCCC		37.8025293948
230PhosphorylationKPDPVFQSPSTVLRL
CCCCCCCCHHHHHHH		14.8926824392
232PhosphorylationDPVFQSPSTVLRLVL
CCCCCCHHHHHHHHH		36.0728066266
233PhosphorylationPVFQSPSTVLRLVLS
CCCCCHHHHHHHHHC		27.2629550500
240PhosphorylationTVLRLVLSGEKKEQA
HHHHHHHCCCCHHHC		37.1126824392
251 (in isoform 3)Phosphorylation-28.0919144319
253PhosphorylationQAGQMPETAAGEPTP
HCCCCCCCCCCCCCC		18.8824453211
259PhosphorylationETAAGEPTPEPPRTS
CCCCCCCCCCCCCCC		35.6624453211
264MethylationEPTPEPPRTSSPTSL
CCCCCCCCCCCCCCC		58.94-
265PhosphorylationPTPEPPRTSSPTSLP
CCCCCCCCCCCCCCC		39.0524925903
266PhosphorylationTPEPPRTSSPTSLPP
CCCCCCCCCCCCCCC		35.2824925903
267PhosphorylationPEPPRTSSPTSLPPL
CCCCCCCCCCCCCCC		31.4224925903
269PhosphorylationPPRTSSPTSLPPLAR
CCCCCCCCCCCCCHH		44.8624925903
270PhosphorylationPRTSSPTSLPPLARS
CCCCCCCCCCCCHHC		42.1125521595
277PhosphorylationSLPPLARSSLPSPMS
CCCCCHHCCCCCCCH		30.5326239621
278PhosphorylationLPPLARSSLPSPMSA
CCCCHHCCCCCCCHH		38.4526239621
281PhosphorylationLARSSLPSPMSAALS
CHHCCCCCCCHHHHH		38.2328833060
283PhosphorylationRSSLPSPMSAALSSQ
HCCCCCCCHHHHHCC		5.0924719451
284PhosphorylationSSLPSPMSAALSSQP
CCCCCCCHHHHHCCC		17.4926239621
288PhosphorylationSPMSAALSSQPLFTA
CCCHHHHHCCCCCCC		23.3828833060
289PhosphorylationPMSAALSSQPLFTAE
CCHHHHHCCCCCCCC		36.3523984901
303PhosphorylationEDKCELPSSKEEDAP
CCCCCCCCCCCCCCC		67.6723140645
304PhosphorylationDKCELPSSKEEDAPP
CCCCCCCCCCCCCCC		41.9923140645
314PhosphorylationEDAPPVPSPTSCTAA
CCCCCCCCCCCCCCC		40.8327087446
316PhosphorylationAPPVPSPTSCTAASG
CCCCCCCCCCCCCCC		40.5525521595
317PhosphorylationPPVPSPTSCTAASGP
CCCCCCCCCCCCCCC		16.9225521595
319PhosphorylationVPSPTSCTAASGPSL
CCCCCCCCCCCCCCC		25.6525521595
322PhosphorylationPTSCTAASGPSLTDN
CCCCCCCCCCCCCCC		49.0927087446
325PhosphorylationCTAASGPSLTDNSDI
CCCCCCCCCCCCCCC		47.6427087446
327PhosphorylationAASGPSLTDNSDICK
CCCCCCCCCCCCCCC		37.1623140645
399PhosphorylationEELKVECTPTPIAPS
HHCCCEEECCCCCHH		19.3822324799
401PhosphorylationLKVECTPTPIAPSML
CCCEEECCCCCHHHC		14.8022324799
406PhosphorylationTPTPIAPSMLPAFSP
ECCCCCHHHCCCCCC		24.7523649490
412PhosphorylationPSMLPAFSPAPPTPP
HHHCCCCCCCCCCCC		23.4326745281
417PhosphorylationAFSPAPPTPPTSPPC
CCCCCCCCCCCCCCC		40.6222324799
420PhosphorylationPAPPTPPTSPPCPPV
CCCCCCCCCCCCCCC		55.8822324799
421PhosphorylationAPPTPPTSPPCPPVV
CCCCCCCCCCCCCCH		32.3922324799
430PhosphorylationPCPPVVLSAAIARSP
CCCCCHHHHHHHCCH		12.2126745281
436PhosphorylationLSAAIARSPAVATEV
HHHHHHCCHHHHHHH		14.2726824392
441PhosphorylationARSPAVATEVQRVAD
HCCHHHHHHHHHHHH		30.0427180971
470PhosphorylationEMQDKAESESDGQAE
HHHHHHHHCCCCCCC		47.4625521595
472PhosphorylationQDKAESESDGQAEET
HHHHHHCCCCCCCCC		57.2125521595
479PhosphorylationSDGQAEETADPQSLH
CCCCCCCCCCCCCCC		28.0627742792
483 (in isoform 3)Phosphorylation-60.2019144319
484PhosphorylationEETADPQSLHSGRSP
CCCCCCCCCCCCCCC		33.1825619855
487PhosphorylationADPQSLHSGRSPAPV
CCCCCCCCCCCCCCC		40.9919060867
490PhosphorylationQSLHSGRSPAPVQTA
CCCCCCCCCCCCCCC		29.0121082442
496PhosphorylationRSPAPVQTATTAPKS
CCCCCCCCCCCCCCC		26.6325293948
498PhosphorylationPAPVQTATTAPKSWK
CCCCCCCCCCCCCHH		27.2125293948
499PhosphorylationAPVQTATTAPKSWKK
CCCCCCCCCCCCHHC		38.2025293948
505AcetylationTTAPKSWKKTKEQTR
CCCCCCHHCCCCCCC		58.6219847707
506AcetylationTAPKSWKKTKEQTRT
CCCCCHHCCCCCCCC		59.5819847717
511PhosphorylationWKKTKEQTRTPDEVL
HHCCCCCCCCHHHHH		37.2922942356
513PhosphorylationKTKEQTRTPDEVLEA
CCCCCCCCHHHHHHH		38.1825521595
534PhosphorylationEEELAVDSVLEPEQE
HHHHHHCCCCCHHHH		23.2329899451
578PhosphorylationPVRNGAESASEGEGG
CCCCCCCCCCCCCCC		36.2421183079
580PhosphorylationRNGAESASEGEGGDG
CCCCCCCCCCCCCCC		56.2521183079
589PhosphorylationGEGGDGNSGSADSSA
CCCCCCCCCCCCCCC		39.3929899451
591PhosphorylationGGDGNSGSADSSADG
CCCCCCCCCCCCCCC		28.8229899451
657PhosphorylationKINQPRLSMRTLDPR
CCCCCCCCCCCCCCC		13.9022324799
687MethylationPRQTPGGRGVPLLNV
CCCCCCCCCCCCCCC		49.18-
714PhosphorylationPRKIITVSVKEDVHL
CCEEEEEEECCCCHH		20.8728542873
736PhosphorylationKPSQKRDSHADDPES
CCCCCCCCCCCCHHH		25.3029899451
755PhosphorylationELFRKVRSILNKLTP
HHHHHHHHHHHHHCH		34.1225159016
808S-palmitoylationSVAYANMCRCLVTLK
HHHHHHCCCCEEEEE		2.5228680068
884PhosphorylationKDKARRRSIGNIKFI
HHHHHHHHHCCCHHH		32.7923684622
896UbiquitinationKFIGELFKLKMLTEA
HHHHHHHHHHHHHHH		60.88-
1045PhosphorylationNSRVLDPSKFLKITK
CCCCCCHHHCCCCCC		35.3918779572
1069PhosphorylationVPKAQLGSWGKGSSG
CCHHHHCCCCCCCCC		41.05-
1081 (in isoform 2)Phosphorylation-36.6123984901
1083 (in isoform 2)Phosphorylation-26.2023984901
1086 (in isoform 2)Phosphorylation-7.0129899451
1088PhosphorylationSESDALRSSASSLNR
CHHHHHHHHCHHCCC		30.9825338131
1088 (in isoform 2)Phosphorylation-30.9830352176
1090 (in isoform 2)Phosphorylation-12.3728464351
1092 (in isoform 2)Phosphorylation-29.4023984901
1098 (in isoform 2)Phosphorylation-32.1023984901
1099 (in isoform 4)Phosphorylation-13.3123984901
1101 (in isoform 4)Phosphorylation-34.4023984901
1104 (in isoform 4)Phosphorylation-45.0229899451
1105PhosphorylationPLQPPAPSGSPSATP
CCCCCCCCCCCCCCC		54.7525293948
1106 (in isoform 4)Phosphorylation-42.3830352176
1107PhosphorylationQPPAPSGSPSATPLE
CCCCCCCCCCCCCCC		21.7325293948
1108 (in isoform 4)Phosphorylation-31.3528464351
1109PhosphorylationPAPSGSPSATPLEFD
CCCCCCCCCCCCCCH		46.6125293948
1110 (in isoform 4)Phosphorylation-19.3423984901
1111PhosphorylationPSGSPSATPLEFDSR
CCCCCCCCCCCCHHH		32.5125293948
1116 (in isoform 4)Phosphorylation-31.6823984901
1122PhosphorylationFDSRRALTSRGSMGR
CHHHHHHHCCCCCCC		18.5225367039
1123PhosphorylationDSRRALTSRGSMGRE
HHHHHHHCCCCCCCC		35.1825266776
1125PhosphorylationRRALTSRGSMGREKS
HHHHHCCCCCCCCCC		23.0424719451
1126PhosphorylationRALTSRGSMGREKSD
HHHHCCCCCCCCCCC		19.5625266776
1145PhosphorylationAGTARPNTFLRGSSK
CCCCCCCCCCCCCHH		27.0829472430
1150PhosphorylationPNTFLRGSSKDLLDN
CCCCCCCCHHHHHCC		27.9927742792
1151PhosphorylationNTFLRGSSKDLLDNQ
CCCCCCCHHHHHCCC		32.7726824392
1159PhosphorylationKDLLDNQSQEEQRRE
HHHHCCCCHHHHHHH		45.9028833060
1184PhosphorylationGLDAERASTEADRSK
CCCHHHHCHHHHHHH		32.7625338131
1212PhosphorylationAPDKPALSEEEVERK
CCCCCCCCHHHHHHH		45.10-
1276PhosphorylationDHMGHLLYQLVQSEK
HHHHHHHHHHHHCHH		13.2228576409
1286UbiquitinationVQSEKLSKQDFFKGF
HHCHHHCHHHHHHHH		65.41-
1426AcetylationELSQRLEKLIMEEKA
HHHHHHHHHHHHHCC		48.166566259
1432AcetylationEKLIMEEKADDERIF
HHHHHHHCCCCHHHH		43.756566247
1473GlutathionylationKAAIIADCSTFRVDT
HHHHHHCCCCCCCCH		2.8124333276
1480PhosphorylationCSTFRVDTAVIKQRV
CCCCCCCHHHHHHHH		21.7019854140
1541PhosphorylationVISEDAFYKWESSKD
CCCHHHCHHHHHCCC		19.5318515860
1576PhosphorylationLREAEEESEDN----
HHHHHHHHCCC----		54.2327087446
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1150SPhosphorylationKinaseCAMK1Q91YS8
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF4G3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF4G3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of IF4G3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF4G3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470 AND SER-472, ANDMASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.

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