INT6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT6_MOUSE
• UniProt AC: Q6PCM2
• Protein Name: Integrator complex subunit 6
• Gene Name: Ints6
• Organism: Mus musculus (Mouse).
• Sequence Length: 883
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex..
• Protein Sequence: MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPPPAEEGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQVLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPSMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPPAPMTQAQPGLIKPLPLHKEATNDSIVDDVVENHVADQLSSDMTPNAMDTEFLTSPPNLLEPSTNHTEALGHEHLGNNDLTVGGFLENHEEPRNKEQSAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
150	Phosphorylation	ELHLPLNSPLPGSEL EEECCCCCCCCCCHH	35.18	25266776
155	Phosphorylation	LNSPLPGSELTKEPF CCCCCCCCHHCCCCC	27.74	26745281
411	Phosphorylation	PTLKWRQSFESYLKT CCCHHHHHHHHHHHH	23.55	30635358
414	Phosphorylation	KWRQSFESYLKTMPP HHHHHHHHHHHHCCC	33.48	30635358
415	Phosphorylation	WRQSFESYLKTMPPY HHHHHHHHHHHCCCC	12.67	30635358
418	Phosphorylation	SFESYLKTMPPYYLG HHHHHHHHCCCCHHH	32.11	30635358
422	Phosphorylation	YLKTMPPYYLGPLKK HHHHCCCCHHHHHHH	12.88	30635358
423	Phosphorylation	LKTMPPYYLGPLKKA HHHCCCCHHHHHHHH	15.79	30635358
660	Phosphorylation	PKRRRCASPLLRGRR CCHHCCCCHHHCCCC	21.51	22942356
669	Phosphorylation	LLRGRRQSPAVNSHI HHCCCCCCHHHCCCC	17.02	25338131
694	Ubiquitination	QAQPGLIKPLPLHKE CCCCCCCCCCCCCCC	45.61	22790023
788	Phosphorylation	EENIPASSLNKGKKL HHCCCHHHCCCCCCC	37.76	25338131
800	Phosphorylation	KKLMHCRSHEEVNTE CCCEECCCHHHHCHH	40.42	25521595
806	Phosphorylation	RSHEEVNTELKAQIM CCHHHHCHHHHHHHH	48.12	25159016
823	Phosphorylation	IRKPGRKYERIFTLL HCCCCHHHHHHHHHH	14.74	21454597
828	Phosphorylation	RKYERIFTLLKHVQG HHHHHHHHHHHHHHH	28.89	21454597
839	Phosphorylation	HVQGSLQTRLIFLQN HHHHCHHHHHHHHHH	32.51	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of INT6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.