dbPTM

CHD1L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHD1L_MOUSE
UniProt AC	Q9CXF7
Protein Name	Chromodomain-helicase-DNA-binding protein 1-like
Gene Name	Chd1l
Organism	Mus musculus (Mouse).
Sequence Length	900
Subcellular Localization	Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1 (By similarity)..
Protein Description	DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity)..
Protein Sequence	MASGLPRFLQALPAEHGPEPLRTRVQEPDLQQWGLTGIRLRSYQLEGVNWLVQCFHCQNGCILGDEMGLGKTCQTIALLIYLVGRLNDEGPFLVLCPLSVLSNWKEEMERFAPGLSCVTYTGDKEERARLQQDLRQESGFHVLLTTYEICLKDASFLKSFSWSVLAVDEAHRLKNQSSLLHRTLSEFSAVFRLLLTGTPIQNSLRELYSLLCVVEPDLFCREQVEDFVQRYQDIEKESKSASELHRLLQPFLLRRVKAQVATELPKKTEVVVYHGMSALQKKYYKAILMKDLDAFENETAKKVKLQNILTQLRKCVDHPYLFDGVEPEPFEVGEHLIEASGKLHLLDRLLAFLYSGGHRVLLFSQMTHMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFGNQPIFVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMVIEGGHFTPGAQKPSAEADFQLSEILKFGLDKLLSSEGSSMEDIDLKSILGETKDGQWTPDALPAAAAAGGGSLEPEEGSELESRSYENHMYLFEGRDYSKEPSKEDRKSFEQLVNLQKTLLEKTSHGGRTLRNKGSVLIPGLAEGPIKRKKILSPEELEDRRKKRQEAAAKRKRLMEEKRKEKEEAEHRKKMAWWESNGYQSFCLSSEDSELEDLEGGDESSAELAYEDLDSTSINYVSGDVTHPQAGEEDAVIVHCVDDSGRWGRGGLFTALEVRSAEPRKIYELAGKMEDLSLGDVLLFPIDDKESRDKGQDLLALVVAQHRDRTNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLATRGIPTYIYYFPRSKARHSQPASSSSAPLVP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	Phosphorylation	AHRLKNQSSLLHRTL HHHHCCCHHHHHHHH	32.14	24719451
178	Phosphorylation	HRLKNQSSLLHRTLS HHHCCCHHHHHHHHH	25.78	24719451
183	Phosphorylation	QSSLLHRTLSEFSAV CHHHHHHHHHHHHHH	24.72	24719451
534	Phosphorylation	MEDIDLKSILGETKD HHHCCHHHHHCCCCC	30.28	-
596	Phosphorylation	PSKEDRKSFEQLVNL CCHHHHHHHHHHHHH	34.60	22817900
612	Phosphorylation	KTLLEKTSHGGRTLR HHHHHHCCCCCCCCC	31.07	-
623	Phosphorylation	RTLRNKGSVLIPGLA CCCCCCCCEECCCCC	18.50	27600695
641	Phosphorylation	IKRKKILSPEELEDR CCCCCCCCHHHHHHH	33.47	28066266
795	Phosphorylation	FPIDDKESRDKGQDL EECCCHHHHHCCHHH	52.07	26239621
894	Phosphorylation	HSQPASSSSAPLVP- CCCCCCCCCCCCCC-	28.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHD1L_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHD1L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHD1L_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CHD1L_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHD1L_MOUSE

Related Literatures of Post-Translational Modification