CD2B2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD2B2_MOUSE
• UniProt AC: Q9CWK3
• Protein Name: CD2 antigen cytoplasmic tail-binding protein 2
• Gene Name: Cd2bp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 342
• Subcellular Localization: Cytoplasm. Nucleus. Predominantly nuclear..
• Protein Description: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly..
• Protein Sequence: MPKRKVTFQGVGDEDGEDEISVPKKKLVDPVAAAGGPGSRFKGKHSLDSDEEDDDEEGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNQDAQIRDSWLDNIDWVRIKERPPDKHQVSDSEEEDSLGQTPMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGSNSKGTGRPNSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCRAQGSHDPTPPPSLDMFAEEVAEGELETPTPTQREEAESAGDGLMDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFELYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Acetylation	EISVPKKKLVDPVAA CCCCCHHHCCCHHHH	60.93	23806337
44	Acetylation	PGSRFKGKHSLDSDE CCCCCCCCCCCCCCC	30.52	23806337
46	Phosphorylation	SRFKGKHSLDSDEED CCCCCCCCCCCCCCC	37.04	25521595
49	Phosphorylation	KGKHSLDSDEEDDDE CCCCCCCCCCCCCCC	52.82	25521595
59	Phosphorylation	EDDDEEGSSKYDILA CCCCCCCCCHHEEEE	27.26	26239621
60	Phosphorylation	DDDEEGSSKYDILAS CCCCCCCCHHEEEEC	46.20	26239621
62	Phosphorylation	DEEGSSKYDILASED CCCCCCHHEEEECCC	15.34	26239621
67	Phosphorylation	SKYDILASEDVEGQE CHHEEEECCCCCCCC	30.77	26239621
77	Phosphorylation	VEGQEAATLPSEGGV CCCCCCCCCCCCCCE	46.37	23984901
80	Phosphorylation	QEAATLPSEGGVRIT CCCCCCCCCCCEEEC	52.57	30635358
117	Phosphorylation	QDAQIRDSWLDNIDW CCCCCCHHHHHCCCE	21.49	-
152	Phosphorylation	SLGQTPMSAQALLEG CCCCCCHHHHHHHHH	20.59	-
191	Phosphorylation	KGSNSKGTGRPNSPQ CCCCCCCCCCCCCHH	33.48	25159016
196	Phosphorylation	KGTGRPNSPQRLDRL CCCCCCCCHHHHHHH	25.70	24925903
204	Phosphorylation	PQRLDRLSGLADQMV HHHHHHHHHHHHHHH	32.43	27600695
240	Phosphorylation	LGCRAQGSHDPTPPP CCCCCCCCCCCCCCC	16.79	25293948
244	Phosphorylation	AQGSHDPTPPPSLDM CCCCCCCCCCCCHHH	55.26	25293948
248	Phosphorylation	HDPTPPPSLDMFAEE CCCCCCCCHHHHHHH	42.65	25293948
263	Phosphorylation	VAEGELETPTPTQRE HHCCCCCCCCCCHHH	45.12	25293948
265	Phosphorylation	EGELETPTPTQREEA CCCCCCCCCCHHHHH	46.52	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD2B2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD2B2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD2B2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CD2B2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-196, AND MASSSPECTROMETRY.
PubMed: 19367708

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.
PubMed: 17203969