SP110_MOUSE - dbPTM
SP110_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SP110_MOUSE
UniProt AC Q8BVK9
Protein Name Sp110 nuclear body protein
Gene Name Sp110
Organism Mus musculus (Mouse).
Sequence Length 445
Subcellular Localization Nucleus .
Protein Description May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells..
Protein Sequence MFTLTKALEKALLQHFIYMKVNIAYAINKPFPFFEALRDNSFITERMYKESLEACQNLVPLSKVVHNILTSLEQTFHPSVLLTLFSKVNLREYPSLVAIFRSFRNVGYTYEEKNRPPLTLLEDLANPAEGCSLQTLLPPPRPQISLPSHLSSAPRVCDPRATAQPIIEILDEQPSPSPRAVPLLGCIQEGKTTPVSSRDHQRKDKEDSREMPHSPSGPESVVKDDSPAANDLEMAREVPCTPANKKARRKKRPNWSNSKRRRQKKKPRQDEMMGVASPGHGVQEKLKAVSRRTLWKDDSSTNVKEVTKTQRTRMRRAQTSNSQEISKEASKTSGRKRPSTARRTTQVPEKTKNDAVDFSPTLPVTCGKAKGTLFQEKLKQGASKKCIQNEAGDWLTVKEFLNEGGRATSKDWKGVIRCNGETLRHLEQKGLLFFTSKSKPQKKGA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
162PhosphorylationRVCDPRATAQPIIEI
CCCCCCCCCCCHHHH		27.4028285833
175PhosphorylationEILDEQPSPSPRAVP
HHHHCCCCCCCCCCC		37.3926824392
177PhosphorylationLDEQPSPSPRAVPLL
HHCCCCCCCCCCCCE		31.2128725479
192PhosphorylationGCIQEGKTTPVSSRD
EEEECCCCCCCCCCC		47.3825266776
193PhosphorylationCIQEGKTTPVSSRDH
EEECCCCCCCCCCCC		25.7725266776
196PhosphorylationEGKTTPVSSRDHQRK
CCCCCCCCCCCCCCC		22.3627600695
197PhosphorylationGKTTPVSSRDHQRKD
CCCCCCCCCCCCCCC		41.8027600695
208PhosphorylationQRKDKEDSREMPHSP
CCCCHHHCCCCCCCC		31.0923375375
214PhosphorylationDSREMPHSPSGPESV
HCCCCCCCCCCCHHH		18.1922942356
216PhosphorylationREMPHSPSGPESVVK
CCCCCCCCCCHHHCC		70.7422942356
220PhosphorylationHSPSGPESVVKDDSP
CCCCCCHHHCCCCCC		35.0321082442
226PhosphorylationESVVKDDSPAANDLE
HHHCCCCCCCCCCHH		26.9425521595
241PhosphorylationMAREVPCTPANKKAR
HHHHCCCCHHCHHHH		21.2627600695
256PhosphorylationRKKRPNWSNSKRRRQ
HHCCCCCCHHHHHHH		37.5527600695
258PhosphorylationKRPNWSNSKRRRQKK
CCCCCCHHHHHHHHC		23.2525266776
277PhosphorylationDEMMGVASPGHGVQE
HHHCCCCCCCCCHHH		29.0728833060
299PhosphorylationRTLWKDDSSTNVKEV
CCCCCCCCCCCHHHH		49.5527600695
300PhosphorylationTLWKDDSSTNVKEVT
CCCCCCCCCCHHHHH		30.8725266776
319PhosphorylationTRMRRAQTSNSQEIS
HHHHHHHCCCHHHHH		28.9628285833
320PhosphorylationRMRRAQTSNSQEISK
HHHHHHCCCHHHHHH		23.5430635358
322PhosphorylationRRAQTSNSQEISKEA
HHHHCCCHHHHHHHH		29.0230635358
326PhosphorylationTSNSQEISKEASKTS
CCCHHHHHHHHHHHC		24.5630635358
339O-linked_GlycosylationTSGRKRPSTARRTTQ
HCCCCCCCCCCCCCC		38.4430059200
340O-linked_GlycosylationSGRKRPSTARRTTQV
CCCCCCCCCCCCCCC		27.1930059200
351PhosphorylationTTQVPEKTKNDAVDF
CCCCCCCCCCCCCCC		33.1630635358
359PhosphorylationKNDAVDFSPTLPVTC
CCCCCCCCCCCCCCC		16.7125266776
361PhosphorylationDAVDFSPTLPVTCGK
CCCCCCCCCCCCCCC		42.3622942356
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SP110_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SP110_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SP110_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SP110_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SP110_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-177, ANDMASS SPECTROMETRY.

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