PPIG_MOUSE - dbPTM
PPIG_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPIG_MOUSE
UniProt AC A2AR02
Protein Name Peptidyl-prolyl cis-trans isomerase G
Gene Name Ppig
Organism Mus musculus (Mouse).
Sequence Length 752
Subcellular Localization Nucleus matrix . Nucleus speckle . Colocalizes with splicing factors at nuclear speckles.
Protein Description PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing..
Protein Sequence MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADREQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
122PhosphorylationRGKDTNGSQFFITTK
CCCCCCCCCEEEECC		26.3620469934
173PhosphorylationFAEVRILSCGELIPK
CCEEEEEECCCCCCH		20.0822006019
180AcetylationSCGELIPKSKVKKEE
ECCCCCCHHHCCHHH		56.7823806337
182AcetylationGELIPKSKVKKEEKK
CCCCCHHHCCHHHHH		65.292415319
184AcetylationLIPKSKVKKEEKKRH
CCCHHHCCHHHHHHC		59.202415327
214PhosphorylationDSQSSSESSDSESAS
CCCCCCCCCCCHHHH		41.20-
249PhosphorylationEKKKRKKSKKSPSSE
HHHHHHHCCCCCCCH		48.6427841257
252PhosphorylationKRKKSKKSPSSESEA
HHHHCCCCCCCHHHH		33.4818388127
254PhosphorylationKKSKKSPSSESEAEN
HHCCCCCCCHHHHHC		54.5525521595
255PhosphorylationKSKKSPSSESEAENV
HCCCCCCCHHHHHCC		48.8325521595
257PhosphorylationKKSPSSESEAENVDA
CCCCCCHHHHHCCCC		44.0125521595
268PhosphorylationNVDAQPQSTVRPEEI
CCCCCCCCCCCHHHC		35.2423429704
269PhosphorylationVDAQPQSTVRPEEIP
CCCCCCCCCCHHHCC		18.4523429704
288PhosphorylationNRFLMRKSPPKADDK
CCCCCCCCCCCCCHH		35.7526824392
313PhosphorylationRECNPPNSQPASYQR
HHCCCCCCCCCHHHH		43.23-
339PhosphorylationKGRGPRRYRTPSRSR
CCCCCCCCCCCCCCC		21.8127681418
341PhosphorylationRGPRRYRTPSRSRSR
CCCCCCCCCCCCCCH		19.3822817900
343PhosphorylationPRRYRTPSRSRSRDR
CCCCCCCCCCCCHHH		42.1322817900
345PhosphorylationRYRTPSRSRSRDRFR
CCCCCCCCCCHHHHH		38.6622817900
354PhosphorylationSRDRFRRSETPPHWR
CHHHHHHCCCCHHHH		41.3825521595
356PhosphorylationDRFRRSETPPHWRQE
HHHHHCCCCHHHHHH		43.2818388127
373PhosphorylationRAQRMRVSSGERWIK
HHHHHHCCCCCHHHC		23.4325266776
374PhosphorylationAQRMRVSSGERWIKG
HHHHHCCCCCHHHCC		41.6425266776
384PhosphorylationRWIKGDKSELNEIKE
HHHCCCHHHHHHHHH		52.6428833060
395PhosphorylationEIKENQRSPVRVKEK
HHHHHCCCCCCCEEC		20.2726824392
405PhosphorylationRVKEKKITDHRHMSE
CCEECCCCCCCCCCC		34.3327717184
411PhosphorylationITDHRHMSESPNRKV
CCCCCCCCCCCCHHH		28.8827087446
413PhosphorylationDHRHMSESPNRKVEK
CCCCCCCCCCHHHHH		21.8427087446
429PhosphorylationKKAKDHKSESKERDI
HHHHHCCCHHHHHHH		43.6226824392
431PhosphorylationAKDHKSESKERDIRR
HHHCCCHHHHHHHHH		47.0826824392
495PhosphorylationSKERDHETTKEKEKP
HHHCCCCHHCCCCCC		39.4828576409
496PhosphorylationKERDHETTKEKEKPL
HHCCCCHHCCCCCCC		33.9328576409
513PhosphorylationKGKDQERSRSKENSK
CCHHHHHHHCHHHHH		39.90-
515PhosphorylationKDQERSRSKENSKQV
HHHHHHHCHHHHHHH		45.64-
534PhosphorylationNEHDHSKSKEKDRRA
CCCCCHHHHHHHHHH		49.4125266776
543PhosphorylationEKDRRAQSRSRERDL
HHHHHHHHHHHHHHH		31.1027717184
545PhosphorylationDRRAQSRSRERDLTK
HHHHHHHHHHHHHHH		43.6827717184
559PhosphorylationKSKHSYNSRTRERSR
HCHHCHHHHHHHHHH		27.1325266776
576PhosphorylationDRSRRVRSRSHDRDR
HHHHHHHHCCHHCCH		34.9729899451
578PhosphorylationSRRVRSRSHDRDRSR
HHHHHHCCHHCCHHH		30.8729899451
584PhosphorylationRSHDRDRSRSKEYHR
CCHHCCHHHHHHHHH		45.2428066266
586PhosphorylationHDRDRSRSKEYHRYR
HHCCHHHHHHHHHHH		30.9628066266
597PhosphorylationHRYREQEYRRRGRSR
HHHHHHHHHHHCCCC		14.7625338131
610PhosphorylationSRSRDRRTPGRSRSK
CCCCCCCCCCCCCHH		30.8719854140
614PhosphorylationDRRTPGRSRSKDRRR
CCCCCCCCCHHHHHH		46.9819854140
626PhosphorylationRRRRRRDSRSSEREE
HHHHHHHHHHHHHHH		32.0523684622
628PhosphorylationRRRRDSRSSEREESQ
HHHHHHHHHHHHHHH		40.2723684622
629PhosphorylationRRRDSRSSEREESQS
HHHHHHHHHHHHHHH		39.2923684622
634PhosphorylationRSSEREESQSRNKDK
HHHHHHHHHHHHHHH		28.8028066266
636PhosphorylationSEREESQSRNKDKYR
HHHHHHHHHHHHHHH		47.2928066266
656PhosphorylationSSHRKENSEGEKRTY
HHCCCCCCCCCCHHC		48.3327087446
685PhosphorylationKKADREQSPVSKTKQ
HHHHHHCCCCCCCCC		23.6325521595
688PhosphorylationDREQSPVSKTKQSSQ
HHHCCCCCCCCCCCC		37.6826824392
693PhosphorylationPVSKTKQSSQDNEVK
CCCCCCCCCCCCCHH		31.3630635358
694PhosphorylationVSKTKQSSQDNEVKS
CCCCCCCCCCCCHHH		38.7727087446
712PhosphorylationKNQEDEKTRSPVEKE
CCCCCHHCCCHHHHH		34.0425159016
714PhosphorylationQEDEKTRSPVEKENQ
CCCHHCCCHHHHHHH		38.2325521595
742PhosphorylationNKKCDHESSPGTDED
CCCCCCCCCCCCCCC		38.1125521595
743PhosphorylationKKCDHESSPGTDEDK
CCCCCCCCCCCCCCC		25.1025521595
746PhosphorylationDHESSPGTDEDKSG-
CCCCCCCCCCCCCC-		39.3325521595
751PhosphorylationPGTDEDKSG------
CCCCCCCCC------		63.1622324799
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPIG_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPIG_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPIG_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PPIG_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPIG_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; SER-345; SER-742;SER-743 AND THR-746, AND MASS SPECTROMETRY.

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