APLF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APLF_MOUSE
• UniProt AC: Q9D842
• Protein Name: Aprataxin and PNK-like factor
• Gene Name: Aplf
• Organism: Mus musculus (Mouse).
• Sequence Length: 499
• Subcellular Localization: Nucleus. Cytoplasm, cytosol. Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (By similarity)..
• Protein Description: Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity)..
• Protein Sequence: MPSDFFLQPLDGGPRVPVGPGQTVIGRGPLLGITDKRVSRRHAILEVVDSQLRIKPIHRNPCFYQSSEKSQHSPMETQVWSQLHPGDSFSLLLDKYAFRVFSAESEVEMECTLRNSQMLDEDDILSEMQKSPVVNLPDKTTGASQLQGSPEITKTKCPTIDPMSSSGECRAFSEHQPRPTQRKRILPAWMLAESLSDQSLSTPAEGGDKDVIQRSGKAGTCEDRTPGNTSWHGKKRLSPSGNSKSVSAEQDPGKKCRKADQEGPGVSSENVPESSSSNIVKDPDVDIVKTNKQKDGILIEELGEVSKHKAATKPTTNEEGESCARVQSKSPPEKSQGCHPESSSAPSSPDALHTDTADPVLGCSEESKVRRTACMYGANCYRRNPLHFQHFSHPGDSDYGEVHGTDEGVIGDRPECPYGASCYRKNPQHKMEYRHSALPARVALDEDDDDVGQPSDDEDEEDYEPTDEDSDWHPGKDDEEQEDVDELLKEAKSSLHLKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Phosphorylation	MECTLRNSQMLDEDD EEEEECCCCCCCHHH	15.55	26160508
126	Phosphorylation	LDEDDILSEMQKSPV CCHHHHHHHHHHCCC	31.21	21149613
131	Phosphorylation	ILSEMQKSPVVNLPD HHHHHHHCCCCCCCC	13.16	25521595
140	Phosphorylation	VVNLPDKTTGASQLQ CCCCCCCCCCCHHHC	37.53	25619855
141	Phosphorylation	VNLPDKTTGASQLQG CCCCCCCCCCHHHCC	36.17	25619855
144	Phosphorylation	PDKTTGASQLQGSPE CCCCCCCHHHCCCCC	32.54	25619855
149	Phosphorylation	GASQLQGSPEITKTK CCHHHCCCCCCCCCC	13.34	25521595
153	Phosphorylation	LQGSPEITKTKCPTI HCCCCCCCCCCCCCC	30.88	25619855
238	Phosphorylation	WHGKKRLSPSGNSKS CCCCEEECCCCCCCC	22.51	27087446
240	Phosphorylation	GKKRLSPSGNSKSVS CCEEECCCCCCCCCC	47.43	22324799
328	Phosphorylation	ESCARVQSKSPPEKS CCCCHHCCCCCCHHH	32.04	27681418
330	Phosphorylation	CARVQSKSPPEKSQG CCHHCCCCCCHHHCC	51.43	30352176
335	Phosphorylation	SKSPPEKSQGCHPES CCCCCHHHCCCCCCC	30.09	21149613
342	Phosphorylation	SQGCHPESSSAPSSP HCCCCCCCCCCCCCC	33.76	21149613
343	Phosphorylation	QGCHPESSSAPSSPD CCCCCCCCCCCCCCC	28.94	27149854
344	Phosphorylation	GCHPESSSAPSSPDA CCCCCCCCCCCCCCH	54.18	27087446
347	Phosphorylation	PESSSAPSSPDALHT CCCCCCCCCCCHHCC	54.97	27087446
348	Phosphorylation	ESSSAPSSPDALHTD CCCCCCCCCCHHCCC	26.24	27087446
354	Phosphorylation	SSPDALHTDTADPVL CCCCHHCCCCCCCCC	35.58	21149613
356	Phosphorylation	PDALHTDTADPVLGC CCHHCCCCCCCCCCC	33.83	21149613
364	Phosphorylation	ADPVLGCSEESKVRR CCCCCCCCCHHHHHH	42.47	25293948
367	Phosphorylation	VLGCSEESKVRRTAC CCCCCCHHHHHHHHH	32.19	25293948
436	Phosphorylation	HKMEYRHSALPARVA CCHHHCCCCCCCEEE	23.62	25338131
455	Phosphorylation	DDDVGQPSDDEDEED CCCCCCCCCCCCHHH	50.21	25195567
466	Phosphorylation	DEEDYEPTDEDSDWH CHHHCCCCCCCCCCC	39.83	25338131
470	Phosphorylation	YEPTDEDSDWHPGKD CCCCCCCCCCCCCCC	40.32	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
116	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APLF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APLF_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of APLF_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.