ORC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ORC2_MOUSE
• UniProt AC: Q60862
• Protein Name: Origin recognition complex subunit 2
• Gene Name: Orc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 576
• Subcellular Localization: Nucleus.
• Protein Description: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity)..
• Protein Sequence: MSTLQLKETKVPSVQFVGDDDVLSHILDREGGTKLKKEKAQLLVNPQKVIKKADCELEKSDLEVLEDQNYVKVLGRNIQESLGNGSAKDGRNKVYSFQQRKHPEEMTKLALELAKTSGKKDPLDSNDPEITKNIAQKSKGHSTSEKAPLVNNNKTEFLSTQPHNLRKRIIASRSHYDSESEYSASSSEDDEEATKDEEEDTNVARLSQKSQGQNRLLPAPVSKETLPKKKKRDKASDLVEEYFEAHSSSKVLTSDRTLQRLRRARVDQKTLHNLLRKFVPSFSAEIERLNQQHEKLFHKWMLQLHLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGYFPGVSVKSILNSITEDVLSHVGTFQSVLDQRDWIINRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLHNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKFQLDNQDSPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGILADFLEKEEEEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	ADCELEKSDLEVLED HCCCCCHHHHHHHCC	37.74	25619855
70	Phosphorylation	EVLEDQNYVKVLGRN HHHCCCCHHHHHCCC	8.94	25159016
116	Phosphorylation	LALELAKTSGKKDPL HHHHHHHHHCCCCCC	36.78	-
187	Phosphorylation	SEYSASSSEDDEEAT CCCCCCCCCCHHHHC	42.42	21947279
225	Phosphorylation	PAPVSKETLPKKKKR CCCCCHHHCCCHHCC	52.69	-
247	Phosphorylation	EEYFEAHSSSKVLTS HHHHHHHCCCCCCCC	43.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ORC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ORC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ORC2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GO45_MOUSE	Blzf1	physical	20211142
ORC1_HUMAN	ORC1	physical	26496610
ORC5_HUMAN	ORC5	physical	26496610
BRAP_HUMAN	BRAP	physical	26496610
ORC3_HUMAN	ORC3	physical	26496610
F210A_HUMAN	FAM210A	physical	26496610
LRWD1_HUMAN	LRWD1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.