BCL7C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCL7C_MOUSE
• UniProt AC: O08664
• Protein Name: B-cell CLL/lymphoma 7 protein family member C
• Gene Name: Bcl7c
• Organism: Mus musculus (Mouse).
• Sequence Length: 217
• Protein Description: May play an anti-apoptotic role..
• Protein Sequence: MAGRTVRAETRSRAKDDIKKVMATIEKVRRWEKRWVTVGDTSLRIFKWVPVVDPQEEERRRAGGGAERSRGRERRGRGTSPRGGGPLILLDLNDENSNQSFHSEGSLQKGAEPSPGGTPQPSRPGSPTGPPEVITEDTQPPQLGQERDPGGTPAGGTDEPPKLTKEEPVPELLEAEAPEAYPVFEPVPSVPEAAQGDTEDSEGAPPLKRICPNAPDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Acetylation	RAKDDIKKVMATIEK HCHHHHHHHHHHHHH	37.26	19854241
27	Acetylation	KVMATIEKVRRWEKR HHHHHHHHHHHHHHC	36.87	19854251
79	Phosphorylation	RERRGRGTSPRGGGP CCCCCCCCCCCCCCC	33.91	26643407
80	Phosphorylation	ERRGRGTSPRGGGPL CCCCCCCCCCCCCCE	18.54	26643407
97	Phosphorylation	LDLNDENSNQSFHSE EECCCCCCCCCCCCC	33.91	27087446
100	Phosphorylation	NDENSNQSFHSEGSL CCCCCCCCCCCCCCC	29.22	27087446
103	Phosphorylation	NSNQSFHSEGSLQKG CCCCCCCCCCCCCCC	41.46	22802335
106	Phosphorylation	QSFHSEGSLQKGAEP CCCCCCCCCCCCCCC	24.47	21082442
114	Phosphorylation	LQKGAEPSPGGTPQP CCCCCCCCCCCCCCC	27.90	27087446
118	Phosphorylation	AEPSPGGTPQPSRPG CCCCCCCCCCCCCCC	25.35	27087446
122	Phosphorylation	PGGTPQPSRPGSPTG CCCCCCCCCCCCCCC	45.95	27087446
126	Phosphorylation	PQPSRPGSPTGPPEV CCCCCCCCCCCCCCC	23.21	21082442
128	Phosphorylation	PSRPGSPTGPPEVIT CCCCCCCCCCCCCCC	65.11	25619855
135	Phosphorylation	TGPPEVITEDTQPPQ CCCCCCCCCCCCCCC	32.74	25619855
138	Phosphorylation	PEVITEDTQPPQLGQ CCCCCCCCCCCCCCC	36.42	25619855
152	Phosphorylation	QERDPGGTPAGGTDE CCCCCCCCCCCCCCC	18.84	27841257
189	Phosphorylation	PVFEPVPSVPEAAQG CCCCCCCCCCHHHCC	51.00	29514104
198	Phosphorylation	PEAAQGDTEDSEGAP CHHHCCCCCCCCCCC	48.82	25338131
201	Phosphorylation	AQGDTEDSEGAPPLK HCCCCCCCCCCCCHH	31.53	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BCL7C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCL7C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCL7C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACL6A_HUMAN	ACTL6A	physical	26496610
MARK3_HUMAN	MARK3	physical	26496610
REQU_HUMAN	DPF2	physical	26496610
SMCA2_HUMAN	SMARCA2	physical	26496610
SMCA4_HUMAN	SMARCA4	physical	26496610
SNF5_HUMAN	SMARCB1	physical	26496610
SMRC1_HUMAN	SMARCC1	physical	26496610
SMRC2_HUMAN	SMARCC2	physical	26496610
SMRD2_HUMAN	SMARCD2	physical	26496610
SMCE1_HUMAN	SMARCE1	physical	26496610
ARI1A_HUMAN	ARID1A	physical	26496610
RPP38_HUMAN	RPP38	physical	26496610
ESF1_HUMAN	ESF1	physical	26496610
URFB1_HUMAN	UHRF1BP1	physical	26496610
Z280C_HUMAN	ZNF280C	physical	26496610
ARI1B_HUMAN	ARID1B	physical	26496610
PRR3_HUMAN	PRR3	physical	26496610
SMS2_HUMAN	SGMS2	physical	26496610
ARID2_HUMAN	ARID2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND SER-126, ANDMASS SPECTROMETRY.
PubMed: 15345747