GATA1_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA1_CHICK
• UniProt AC: P17678
• Protein Name: Erythroid transcription factor
• Gene Name: GATA1
• Organism: Gallus gallus (Chicken).
• Sequence Length: 304
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells..
• Protein Sequence: MEFVALGGPDAGSPTPFPDEAGAFLGLGGGERTEAGGLLASYPPSGRVSLVPWADTGTLGTPQWVPPATQMEPPHYLELLQPPRGSPPHPSSGPLLPLSSGPPPCEARECVNCGATATPLWRRDGTGHYLCNACGLYHRLNGQNRPLIRPKKRLLVSKRAGTVCSNCQTSTTTLWRRSPMGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKVSSKGKKRRPPGGGNPSATAGGGAPMGGGGDPSMPPPPPPPAAAPPQSDALYALGPVVLSGHFLPFGNSGGFFGGGAGGYTAPPGLSPQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
151	Acetylation	NRPLIRPKKRLLVSK CCCCCCCCCEEEEEC	40.45	9859997
152	Acetylation	RPLIRPKKRLLVSKR CCCCCCCCEEEEECC	51.46	9859997
158	Acetylation	KKRLLVSKRAGTVCS CCEEEEECCCCCEEC	38.50	9859997
193	Acetylation	NACGLYYKLHQVNRP HHHHHHHHHHHCCCC	26.41	9859997
205	Acetylation	NRPLTMRKDGIQTRN CCCCEECCCCCCCCC	49.86	9859997
214	Acetylation	GIQTRNRKVSSKGKK CCCCCCCCCCCCCCC	50.44	9859997
218	Acetylation	RNRKVSSKGKKRRPP CCCCCCCCCCCCCCC	68.21	9859997
220	Acetylation	RKVSSKGKKRRPPGG CCCCCCCCCCCCCCC	47.01	9859997
221	Acetylation	KVSSKGKKRRPPGGG CCCCCCCCCCCCCCC	63.41	9859997

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GATA1_CHICK !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA1_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA1_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Regulation of activity of the transcription factor GATA-1 byacetylation.";
Boyes J., Byfield P., Nakatani Y., Ogryzko V.;
Nature 396:594-598(1998).
Cited for: INTERACTION WITH EP300, ACETYLATION AT LYS-158; LYS-214; LYS-218 ANDLYS-220, AND MUTAGENESIS OF 151-LYS-LYS-152 AND LYS-158.
PubMed: 9859997