GATA6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA6_MOUSE
• UniProt AC: Q61169
• Protein Name: Transcription factor GATA-6
• Gene Name: Gata6
• Organism: Mus musculus (Mouse).
• Sequence Length: 589
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator that regulates SEMA3C and PLXNA2. [PubMed: 19666519 May regulate genes that protect epithelial cells from bacterial infection (By similarity Involved in gene regulation specifically in the gastric epithelium (By similarity Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression]
• Protein Sequence: MALTDGGWCLPKRFGAAAADAGDSGPFPAREPSSPLSPISSSSSSCSRGGDRGPCGASNCRTPQLDAEAVAGPPGRSLLLSPYASHPFAAAHGAAAPGVAGPGSALSTWEDLLLFTDLDQAATASKLLWSSRGAKLSPFAAEQPEEMYQTLAALSSQGPAAYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLSGLPYLQGAGSGPSNHAGGAGAHPGWSQASADSPPYGGGGAAGGGAAGPGGAGSATAHASARFPYSPSPPMANGAARDPGGYVAAGGTGAGSVSGGGGSLAAMGGREHQYSSLSAARPLNGTYHHHHHHHPTYSPYMAAPLTPAWPAGPFETPVLHSLQGRAGAPLPVPRGPSTDLLEDLSESRECVNCGSIQTPLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKACSGNSSGSVPMTPTSSSSNSDDCTKNTSPSTQATTSGVGASVMSAVGENANPENSDLKYSGQDGLYIGVSLSSPAEVTSSVRQDSWCALALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	PFPAREPSSPLSPIS CCCCCCCCCCCCCCC	39.57	25293948
34	Phosphorylation	FPAREPSSPLSPISS CCCCCCCCCCCCCCC	40.34	21659605
37	Phosphorylation	REPSSPLSPISSSSS CCCCCCCCCCCCCCC	24.46	21659605
40	Phosphorylation	SSPLSPISSSSSSCS CCCCCCCCCCCCCCC	27.79	25293948
41	Phosphorylation	SPLSPISSSSSSCSR CCCCCCCCCCCCCCC	34.65	25293948
263	Phosphorylation	HASARFPYSPSPPMA CHHCCCCCCCCCCCC	30.42	29472430
264	Phosphorylation	ASARFPYSPSPPMAN HHCCCCCCCCCCCCC	21.09	29472430
266	Phosphorylation	ARFPYSPSPPMANGA CCCCCCCCCCCCCCC	35.38	29472430
437	Phosphorylation	SSRRLGLSCANCHTT CHHCCCCCCCCCCCC	14.91	30635358
443	Phosphorylation	LSCANCHTTTTTLWR CCCCCCCCCCCCCHH	28.21	30635358
444	Phosphorylation	SCANCHTTTTTLWRR CCCCCCCCCCCCHHC	9.85	30635358
445	Phosphorylation	CANCHTTTTTLWRRN CCCCCCCCCCCHHCC	20.95	30635358
446	Phosphorylation	ANCHTTTTTLWRRNA CCCCCCCCCCHHCCC	20.14	30635358
447	Phosphorylation	NCHTTTTTLWRRNAE CCCCCCCCCHHCCCC	23.41	30635358
505	Phosphorylation	CSGNSSGSVPMTPTS CCCCCCCCCCCCCCC	25.62	22871156
509	Phosphorylation	SSGSVPMTPTSSSSN CCCCCCCCCCCCCCC	19.83	-
511	Phosphorylation	GSVPMTPTSSSSNSD CCCCCCCCCCCCCCC	31.88	22871156
524	Phosphorylation	SDDCTKNTSPSTQAT CCCCCCCCCCCCHHC	43.50	21659605
525	Phosphorylation	DDCTKNTSPSTQATT CCCCCCCCCCCHHCC	26.67	26643407
527	Phosphorylation	CTKNTSPSTQATTSG CCCCCCCCCHHCCCC	32.68	26643407
528	Phosphorylation	TKNTSPSTQATTSGV CCCCCCCCHHCCCCC	26.13	26643407
531	Phosphorylation	TSPSTQATTSGVGAS CCCCCHHCCCCCCHH	16.21	26643407
532	Phosphorylation	SPSTQATTSGVGASV CCCCHHCCCCCCHHH	26.88	26643407
533	Phosphorylation	PSTQATTSGVGASVM CCCHHCCCCCCHHHH	27.42	26643407
538	Phosphorylation	TTSGVGASVMSAVGE CCCCCCHHHHHHHCC	16.66	26643407
552	Phosphorylation	ENANPENSDLKYSGQ CCCCCCCCCCCCCCC	42.53	-
556	Phosphorylation	PENSDLKYSGQDGLY CCCCCCCCCCCCCEE	25.90	27087446
567	Phosphorylation	DGLYIGVSLSSPAEV CCEEEEEECCCCCCC	19.81	27087446
570	Phosphorylation	YIGVSLSSPAEVTSS EEEEECCCCCCCCCC	33.16	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
264	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
264	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED1_MOUSE	Med1	physical	20211142
NKX21_MOUSE	Nkx2-1	physical	20211142
TTF1_MOUSE	Ttf1	physical	11733512
BMI1_MOUSE	Bmi1	physical	22713603
NKX22_MOUSE	Nkx2-2	physical	16887115
LMCD1_MOUSE	Lmcd1	physical	16199866
GATA1_MOUSE	Gata1	physical	16199866
GATA4_MOUSE	Gata4	physical	16199866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.